在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Uncharacterized protein C11orf73 (C11orf73)

Recombinant Human Uncharacterized protein C11orf73 (C11orf73)

  • 中文名稱(chēng)：
    人HIKESHI重組蛋白
  • 貨號(hào)：
    CSB-YP706632HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    人HIKESHI重組蛋白
  • 貨號(hào)：
    CSB-EP706632HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    人HIKESHI重組蛋白
  • 貨號(hào)：
    CSB-BP706632HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    人HIKESHI重組蛋白
  • 貨號(hào)：
    CSB-MP706632HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HIKESHI
  • Uniprot No.：
  • 別名：
    C11orf73; Chromosome 11 open reading frame 73; CK073_HUMAN; FLJ43020; Hikeshi; HSPC138; HSPC179; L7RN6; Lethal Chr 7 Rinchik 6; OPI10; Protein Hikeshi; Uncharacterized protein C11orf73
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-197
  • 氨基酸序列
    MFGCLVAGRL VQTAAQQVAE DKFVFDLPDY ESINHVVVFM LGTIPFPEGM GGSVYFSYPD SNGMPVWQLL GFVTNGKPSA IFKISGLKSG EGSQHPFGAM NIVRTPSVAQ IGISVELLDS MAQQTPVGNA AVSSVDSFTQ FTQKMLDNFY NFASSFAVSQ AQMTPSPSEM FIPANVVLKW YENFQRRLAQ NPLFWKT
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
  • 基因功能參考文獻(xiàn)：
    1. Our results suggest that HIKESHI is a marker of cancer progression and that the combination of HIKESHI inhibition and hyperthermia is a therapeutic tool for refractory gastric cancer PMID: 28731175
    2. Depletion of Hikeshi renders HeLa cells proteotoxic stress-sensitive through the abrogation of the nuclear function of HSP70s required for HSF1 regulation. PMID: 28980748
    3. A novel homozygous variant in HIKESHI was identified in a patient with hypomyelinating leukoencephalopathy with periventricular cysts and vermian atrophy. Modified interactions inside Hikeshi's hydrophobic pockets induce mutant protein instability. PMID: 28000699
    4. Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene.P.V54L mutation in Hikeshi is associated with absence of nuclear HSP70 during heat shock stress. PMID: 26545878
    5. The crystal structure of Hikeshi explains how Hikeshi participates in the regulation of nuclear import through the recognition of FG-Nups and which part of Hikeshi affects its binding to Hsp70. PMID: 25760597
    6. identify a nuclear import pathway that operates during heat shock stress and is mediated by an evolutionarily conserved protein, Hikeshi (coded by the C11orf73 gene) binds to FG-Nups and translocates through nuclear pores on its own, showing characteristic features of nuclear transport carriers. PMID: 22541429

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Leukodystrophy, hypomyelinating, 13 (HLD13)
  • 亞細(xì)胞定位：
    Cytoplasm. Cytoplasm, cytosol. Nucleus.
  • 蛋白家族：
    OPI10 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 26938

    OMIM: 614908

    KEGG: hsa:51501

    STRING: 9606.ENSP00000278483

    UniGene: Hs.283322



主站蜘蛛池模板： 免费无码毛片一区二区三区a片| 四虎国产精品永久地址入口| 亚洲第一狼人伊人av| 久久精品中文字幕一区| 夜夜夜高潮夜夜爽夜夜爰爰| 久久国产乱子伦精品免费女人| 国产精品青草久久久久福利99| 蜜桃视频无码区在线观看 | 国产男女免费完整视频| 久久综合久久88中字幕文| 国内少妇高潮嗷嗷叫在线播放| 欧美喷潮久久久xxxxx| 精品亚洲一区二区三区四区五区| 少妇与子乱在线观看| 国产真实乱对白精彩久久| 国产黄a三级三级三级| 久久国产劲暴∨内射新川| 国产日韩未满十八禁止观看| 亚洲精品gv天堂无码男同| 国产乡下妇女做爰| 中文字幕一二三区波多野结衣| 无码精品久久久天天影视| 熟妇人妻无码中文字幕| 欧美性xxxx极品少妇| 神马午夜福利不卡片在线| 亚洲卡一卡二乱码新区仙踪| 色综合久久无码五十路人妻| 国产又色又爽又黄的在线观看视频| 日韩做a爰片久久毛片a片| 国产一区日韩二区欧美三区| 无码人妻精品一区二区三区东京热| 女人的天堂a国产在线观看| 三级特黄60分钟在线观看| 国产成人麻豆亚洲综合无码精品| 久久精品第一国产久精国产宅男66 | 日本亚洲欧洲另类图片| 少妇无码av无码专区| 国产色在线 | 亚洲| 97久章草在线视频播放| 亚洲综合色视频在线观看| 久久久久久久久久久国产|