在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

C11orf73 Antibody

  • 中文名稱:
    C11orf73兔多克隆抗體
  • 貨號:
    CSB-PA003035GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    HIKESHI
  • 別名:
    C11orf73 antibody; Chromosome 11 open reading frame 73 antibody; CK073_HUMAN antibody; FLJ43020 antibody; Hikeshi antibody; HSPC138 antibody; HSPC179 antibody; L7RN6 antibody; Lethal Chr 7 Rinchik 6 antibody; OPI10 antibody; Protein Hikeshi antibody; Uncharacterized protein C11orf73 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human C11orf73
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
  • 基因功能參考文獻:
    1. Our results suggest that HIKESHI is a marker of cancer progression and that the combination of HIKESHI inhibition and hyperthermia is a therapeutic tool for refractory gastric cancer PMID: 28731175
    2. Depletion of Hikeshi renders HeLa cells proteotoxic stress-sensitive through the abrogation of the nuclear function of HSP70s required for HSF1 regulation. PMID: 28980748
    3. A novel homozygous variant in HIKESHI was identified in a patient with hypomyelinating leukoencephalopathy with periventricular cysts and vermian atrophy. Modified interactions inside Hikeshi's hydrophobic pockets induce mutant protein instability. PMID: 28000699
    4. Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene.P.V54L mutation in Hikeshi is associated with absence of nuclear HSP70 during heat shock stress. PMID: 26545878
    5. The crystal structure of Hikeshi explains how Hikeshi participates in the regulation of nuclear import through the recognition of FG-Nups and which part of Hikeshi affects its binding to Hsp70. PMID: 25760597
    6. identify a nuclear import pathway that operates during heat shock stress and is mediated by an evolutionarily conserved protein, Hikeshi (coded by the C11orf73 gene) binds to FG-Nups and translocates through nuclear pores on its own, showing characteristic features of nuclear transport carriers. PMID: 22541429

    顯示更多

    收起更多

  • 相關疾病:
    Leukodystrophy, hypomyelinating, 13 (HLD13)
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytosol. Nucleus.
  • 蛋白家族:
    OPI10 family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 26938

    OMIM: 614908

    KEGG: hsa:51501

    STRING: 9606.ENSP00000278483

    UniGene: Hs.283322



主站蜘蛛池模板: 国产真实伦在线观看| 无码精品国产一区二区免费| 日产精品1区2区3区| 国产美女被遭高潮免费网站| 国产jk白丝在线观看免费 | 精品无码久久久久久国产| 无码专区―va亚洲v专区在线| 伊人中文字幕无码专区| 777午夜福利理论电影网| 精品人妻大屁股白浆无码| 中文字幕在线亚洲二区| 日本一卡2卡3卡4卡免费乱码网站| 特黄特色大片免费播放器图片| 国产精品亚洲专区无码不卡| 综合在线视频精品专区| 精品无码乱码av| 天天躁夜夜躁av天天爽| 久久国产精品成人影院| 亚洲精品自偷自拍无码| 国产成人无码视频网站在线观看| 五月丁香综合激情六月久久 | 精品人妻一区二区三区浪潮在线| 丰满大爆乳波霸奶| 人人玩人人添人人澡欧美| 国产在热线精品视频| 久久精品国产99久久久古代| 日本又黄又潮娇喘视频| 老湿机香蕉久久久久久| 日本少妇高潮喷水xxxxxxx| 天天做天天躁天天躁| av天堂久久精品影音先锋| 亚洲丁香婷婷久久一区二区| 久久久久人妻精品一区二区三区| 一本一本久久a久久综合精品蜜桃| 亚洲成av人片在线观l看福利1| 性生交大片免费看女人按摩| 亚洲精品第一国产综合境外资源| 国产欧美综合在线观看第十页| 亚洲欲色欲香天天综合网| 久久aaaa片一区二区| 国产乱码日产精品bd|