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  4. Recombinant Human Ubiquitin-protein ligase E3C (UBE3C), partial

Recombinant Human Ubiquitin-protein ligase E3C (UBE3C), partial

  • 中文名稱：
    人UBE3C重組蛋白
  • 貨號：
    CSB-YP621871HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人UBE3C重組蛋白
  • 貨號：
    CSB-EP621871HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人UBE3C重組蛋白
  • 貨號：
    CSB-EP621871HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人UBE3C重組蛋白
  • 貨號：
    CSB-BP621871HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人UBE3C重組蛋白
  • 貨號：
    CSB-MP621871HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    HectH2; KIAA0010; KIAA10; Ube3c; UBE3C_HUMAN; Ubiquitin protein isopeptide ligase (E3); Ubiquitin protein ligase E3C; Ubiquitin-protein ligase E3C
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
  • 基因功能參考文獻：
    1. miR-542-3p functioned as a tumor suppressor gene in regulating the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via targeting UBE3C. PMID: 28666208
    2. UBE3C promotes melanoma progression, possibly by inducing epithelial-mesenchymal transition in melanoma cells PMID: 26894856
    3. data reveal that high UBE3C expression contributes to glioma progression by ubiquitination and degradation of ANXA7, and thus presents a novel and promising target for glioma therapy. PMID: 26067607
    4. these observations suggest that UBE3C plays an important role in RCC development and progression, and UBE3C may be a novel target for prevention and treatment of ccRCC. PMID: 25658088
    5. UBE3C is a mutant candidate oncogene involved in tumor development and progression of hepatocellular carcinoma. PMID: 24425307
    6. knockdown renders cells more susceptible to the Hsp90 inhibitor 17-AAG, suggesting that UBE3C protects against the harmful accumulation of protein fragments arising from incompletely degraded proteasome substrates. PMID: 24158444
    7. Our findings provide evidence that variations in UBE3C are potent genetic markers of nasal polyps development in Korean asthmatics. PMID: 21881582
    8. negatively regulates type I interferon through ubiquitination of the transcription factors PMID: 21167755
    9. gene polymorphism is associated with the risk of Aspirin-intolerant asthma PMID: 20934631
    10. TIP120B is a specific substrate of KIAA10; both are highly expressed in human skeletal muscle, suggesting that KIAA10 may regulate TIP120B homeostasis specifically in this tissue. PMID: 12692129

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 16803

    OMIM: 614454

    KEGG: hsa:9690

    STRING: 9606.ENSP00000309198

    UniGene: Hs.118351



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