在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3)

Recombinant Human Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3)

  • 中文名稱：
    人UCHL3重組蛋白
  • 貨號：
    CSB-YP025543HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人UCHL3重組蛋白
  • 貨號：
    CSB-EP025543HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人UCHL3重組蛋白
  • 貨號：
    CSB-EP025543HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人UCHL3重組蛋白
  • 貨號：
    CSB-BP025543HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人UCHL3重組蛋白
  • 貨號：
    CSB-MP025543HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    UCHL3
  • Uniprot No.：
  • 別名：
    Ubiquitin carboxyl-terminal hydrolase isozyme L3; Ubiquitin thioesterase L3; Ubiquitin thiolesterase; Ubiquitin thiolesterase L3; UCH L3; UCH-L3; UCHL3; UCHL3_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-230
  • 氨基酸序列
    MEGQRWLPLE ANPEVTNQFL KQLGLHPNWQ FVDVYGMDPE LLSMVPRPVC AVLLLFPITE KYEVFRTEEE EKIKSQGQDV TSSVYFMKQT ISNACGTIGL IHAIANNKDK MHFESGSTLK KFLEESVSMS PEERARYLEN YDAIRVTHET SAHEGQTEAP SIDEKVDLHF IALVHVDGHL YELDGRKPFP INHGETSDET LLEDAIEVCK KFMERDPDEL RFNAIALSAA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.
  • 基因功能參考文獻：
    1. The authors find that UCHL3 regulates COPS5-dependent deneddylation of Cullin1, which is an essential component of SCF(beta-TrCP) complex and associated with SCF(beta-TrCP) activities. The authors further demonstrate that UCHL3 upregulates the levels of SCF(beta-TrCP) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity. PMID: 28583475
    2. Study demonstrated positive correlations between the level and activity of UCHL3 and sperm characteristics and function suggesting that UCHL3 may play a role in male infertility. PMID: 27780264
    3. Using a series of engineered protein substrates, which are similar in size yet differ in secondary structure, we demonstrate that thermal stability is a key factor that significantly affects UCH-L3 hydrolysis. PMID: 25369561
    4. UCH-L3 is a novel regulator of epithelial-mesenchymal transition and cell migration in prostate cancer cells. PMID: 25194810
    5. Data identified of UCHL3 as an essential deubiquitinase in adipogenesis. PMID: 22679485
    6. impaired UCH-L3 function may contribute to the accumulation of full length UBB(+1) in various pathologie PMID: 21762696
    7. 1.45 A resolution crystal structure of human UCH-L3 in complex with the inhibitor ubiquitin vinylmethylester, an inhibitor that forms a covalent adduct with the active site cysteine of ubiquitin-specific proteases PMID: 15531586
    8. Upregulation of UCH-L3 is associated with Uterine Cervical Neoplasms PMID: 16402389
    9. Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations. PMID: 19047059
    10. These results indicate that mono-Ub and Ub dimers may regulate the enzymatic functions of UCH-L1 and UCH-L3, respectively, in vivo. PMID: 19154770
    11. Untangling the folding mechanism of the 5(2)-knotted protein UCH-L3 PMID: 19476499
    12. identification and the sequence-specific assignments for 186 out of the 218 UCH-L3 (230 less 12 prolines) backbone 15N and amide proton resonances PMID: 19636824

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C12 family
  • 組織特異性：
    Highly expressed in heart, skeletal muscle, and testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12515

    OMIM: 603090

    KEGG: hsa:7347

    STRING: 9606.ENSP00000366819

    UniGene: Hs.162241



主站蜘蛛池模板： 老妇女性较大毛片| 100禁毛片免费40分钟视频| 国产人妻久久精品二区三区老狼| 伊人久久丁香色婷婷啪啪| 欧美人与动人物牲交免费观看久久 | 精品人妻伦一二三区久久aaa片| 免费无码一区二区三区a片| 永久免费无码网站在线观看| 男女裸交无遮挡啪啪激情试看| 色偷一区国产精品| 99久久人妻无码精品系列蜜桃| 色欲天天天无码视频| 午夜视频久久久久一区| 亚洲综合色成在线播放| 四虎影视永久免费观看在线| 欧美99久久无码一区人妻a片| 中文字幕人成无码人妻| 国产精品无码av一区二区三区| 大屁股国产白浆一二区| 亚洲性夜夜天天天| 日本电影一区二区三区| 国产熟妇乱xxxxx大屁股网| 亚洲欧美日韩另类精品一区| 99视频有精品视频高清| 亚洲精品乱码久久久久红杏| 性xxxx视频播放免费| 久久久久久国产精品免费免费 | 久久婷婷色综合老司机| 天天综合亚洲色在线精品| 性欧美高清come| 亚洲人成网亚洲欧洲无码| 玖玖资源站无码专区| 综合激情亚洲丁香社区| 国产麻豆 9l 精品三级站| 全部免费毛片在线播放| 国产裸体舞一区二区三区 | 国产一区二区无码蜜芽精品| 日韩一区二区在线观看视频| 久久无码字幕中文久久无码| 国产偷窥熟女精品视频| 久久精品中文字幕第一页|