在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. UCHL3 Antibody

UCHL3 Antibody

  • 中文名稱：
    UCHL3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA257638
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA257638(UCHL3 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA257638(UCHL3 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    UCHL3
  • 別名：
    Ubiquitin carboxyl-terminal hydrolase isozyme L3 antibody; Ubiquitin thioesterase L3 antibody; Ubiquitin thiolesterase antibody; Ubiquitin thiolesterase L3 antibody; UCH L3 antibody; UCH-L3 antibody; UCHL3 antibody; UCHL3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Full length fusion protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.
  • 基因功能參考文獻(xiàn)：
    1. The authors find that UCHL3 regulates COPS5-dependent deneddylation of Cullin1, which is an essential component of SCF(beta-TrCP) complex and associated with SCF(beta-TrCP) activities. The authors further demonstrate that UCHL3 upregulates the levels of SCF(beta-TrCP) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity. PMID: 28583475
    2. Study demonstrated positive correlations between the level and activity of UCHL3 and sperm characteristics and function suggesting that UCHL3 may play a role in male infertility. PMID: 27780264
    3. Using a series of engineered protein substrates, which are similar in size yet differ in secondary structure, we demonstrate that thermal stability is a key factor that significantly affects UCH-L3 hydrolysis. PMID: 25369561
    4. UCH-L3 is a novel regulator of epithelial-mesenchymal transition and cell migration in prostate cancer cells. PMID: 25194810
    5. Data identified of UCHL3 as an essential deubiquitinase in adipogenesis. PMID: 22679485
    6. impaired UCH-L3 function may contribute to the accumulation of full length UBB(+1) in various pathologie PMID: 21762696
    7. 1.45 A resolution crystal structure of human UCH-L3 in complex with the inhibitor ubiquitin vinylmethylester, an inhibitor that forms a covalent adduct with the active site cysteine of ubiquitin-specific proteases PMID: 15531586
    8. Upregulation of UCH-L3 is associated with Uterine Cervical Neoplasms PMID: 16402389
    9. Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations. PMID: 19047059
    10. These results indicate that mono-Ub and Ub dimers may regulate the enzymatic functions of UCH-L1 and UCH-L3, respectively, in vivo. PMID: 19154770
    11. Untangling the folding mechanism of the 5(2)-knotted protein UCH-L3 PMID: 19476499
    12. identification and the sequence-specific assignments for 186 out of the 218 UCH-L3 (230 less 12 prolines) backbone 15N and amide proton resonances PMID: 19636824

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C12 family
  • 組織特異性：
    Highly expressed in heart, skeletal muscle, and testis.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 12515

    OMIM: 603090

    KEGG: hsa:7347

    STRING: 9606.ENSP00000366819

    UniGene: Hs.162241



主站蜘蛛池模板： 国产伦理一区二区| 欧美日本亚洲韩国一区| 99热国产这里只有精品6| 国产精品麻豆成人av电影艾秋| 天堂在线最新版资源www中文| 人妻无码一区二区三区 tv| 亚洲高清专区日韩精品| 国产精品人妻在线观看| 亚 洲 视 频 高 清 无 码| 五十老熟妇乱子伦免费观看| 亚洲一区日韩高清中文字幕亚洲 | а√天堂8资源中文在线| 青草av久久一区二区三区| 夜夜爽妓女8888888视频| 伦伦影院午夜理论片| 九九精品成人免费国产片| 国产农村毛卡片| 亚洲理论电影在线观看| 久久丫精品国产| 中文字幕熟妇人妻在线视频| 精品免费国偷自产在线视频| 国内精品久久久久久tv| 日韩人妻无码一区二区三区99| yyyy11111少妇影院| 爽到高潮无码视频在线观看| 鲁鲁鲁爽爽爽在线视频观看| 在线 无码 中文字幕 强 乱| 国产欧美日韩久久久久| 丰满人妻中伦妇伦精品app| 亚洲国产天堂久久综合| 国产乱人伦偷精品视频下| 男女下面一进一出无遮挡 | 人人澡人人澡人人看添av| 国产亚洲美女精品久久久2020| 中文综合在线观| 亚洲成av大片大片在线播放| 在线日韩av免费永久观看 | 丰满多毛的大隂户毛茸茸| 无码无套少妇18p在线直播| 国产成年无码久久久久毛片| 小雪尝禁果又粗又大的视频|