在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. UCHL3 Antibody

UCHL3 Antibody

  • 中文名稱：
    UCHL3兔多克隆抗體
  • 貨號：
    CSB-PA025543GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    UCHL3
  • 別名：
    Ubiquitin carboxyl-terminal hydrolase isozyme L3 antibody; Ubiquitin thioesterase L3 antibody; Ubiquitin thiolesterase antibody; Ubiquitin thiolesterase L3 antibody; UCH L3 antibody; UCH-L3 antibody; UCHL3 antibody; UCHL3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human UCHL3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.
  • 基因功能參考文獻：
    1. The authors find that UCHL3 regulates COPS5-dependent deneddylation of Cullin1, which is an essential component of SCF(beta-TrCP) complex and associated with SCF(beta-TrCP) activities. The authors further demonstrate that UCHL3 upregulates the levels of SCF(beta-TrCP) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity. PMID: 28583475
    2. Study demonstrated positive correlations between the level and activity of UCHL3 and sperm characteristics and function suggesting that UCHL3 may play a role in male infertility. PMID: 27780264
    3. Using a series of engineered protein substrates, which are similar in size yet differ in secondary structure, we demonstrate that thermal stability is a key factor that significantly affects UCH-L3 hydrolysis. PMID: 25369561
    4. UCH-L3 is a novel regulator of epithelial-mesenchymal transition and cell migration in prostate cancer cells. PMID: 25194810
    5. Data identified of UCHL3 as an essential deubiquitinase in adipogenesis. PMID: 22679485
    6. impaired UCH-L3 function may contribute to the accumulation of full length UBB(+1) in various pathologie PMID: 21762696
    7. 1.45 A resolution crystal structure of human UCH-L3 in complex with the inhibitor ubiquitin vinylmethylester, an inhibitor that forms a covalent adduct with the active site cysteine of ubiquitin-specific proteases PMID: 15531586
    8. Upregulation of UCH-L3 is associated with Uterine Cervical Neoplasms PMID: 16402389
    9. Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations. PMID: 19047059
    10. These results indicate that mono-Ub and Ub dimers may regulate the enzymatic functions of UCH-L1 and UCH-L3, respectively, in vivo. PMID: 19154770
    11. Untangling the folding mechanism of the 5(2)-knotted protein UCH-L3 PMID: 19476499
    12. identification and the sequence-specific assignments for 186 out of the 218 UCH-L3 (230 less 12 prolines) backbone 15N and amide proton resonances PMID: 19636824

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C12 family
  • 組織特異性：
    Highly expressed in heart, skeletal muscle, and testis.
  • 數據庫鏈接：

    HGNC: 12515

    OMIM: 603090

    KEGG: hsa:7347

    STRING: 9606.ENSP00000366819

    UniGene: Hs.162241



主站蜘蛛池模板： 国精产品一区一区三区mba下载| 国内精品自线一区二区三区2021 | 日韩吃奶摸下aa片免费观看 | 高清乱码一区二区三区| 精品国产va久久久久久久冰 | 国产日产高清欧美一区| 亚洲爱婷婷色婷婷五月| 国产精品毛片a∨一区二区三区| 两个人日本www免费版| 国产日产亚洲系列最新美使用方法| 伊人久久综合无码成人网| 人人插人人插人人爽| 人人超碰人摸人爱| 日本一区二区三区免费播放视频站| 99亚洲精品自拍av成人| 67194熟妇在线观看线路| 免费大黄网站在线观| 婷婷久久香蕉五月综合| 狠狠色狠狠色五月激情| 国产精品人妻熟女男人的天堂| 美丽的熟妇中文字幕| 日韩乱码人妻无码中文字幕| 成人无码男男gv在线观看网站| 亚洲 欧美 中文 日韩aⅴ| 国内嫩模私拍精品视频| 99精品偷自拍| 免费国产va在线观看| 亚洲精品入口一区二区乱麻豆精品| 亚洲男人天堂| 免费国产黄网站在线观看动图| 猫咪www免费人成网站无码| 老司机性色福利精品视频| 无码人妻黑人中文字幕| 久久久国产一区二区三区四区小说| 久久精品免视看国产成人| 亚洲欧美成人一区二区在线| 777午夜福利理论电影网| 成人性做爰aaa片免费看| 亚色九九九全国免费视频| 国产公开免费人成视频| 色综合久久无码中文字幕|