在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Ubiquitin carboxyl-terminal hydrolase 5 (USP5), partial

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 5 (USP5), partial

  • 中文名稱：
    人USP5重組蛋白
  • 貨號：
    CSB-YP025742HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人USP5重組蛋白
  • 貨號：
    CSB-EP025742HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人USP5重組蛋白
  • 貨號：
    CSB-EP025742HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人USP5重組蛋白
  • 貨號：
    CSB-BP025742HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人USP5重組蛋白
  • 貨號：
    CSB-MP025742HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    USP5
  • Uniprot No.：
  • 別名：
    Deubiquitinating enzyme 5; Isopeptidase T; ISOT 1; ISOT; Ubiquitin carboxyl-terminal hydrolase 5; Ubiquitin isopeptidase T; Ubiquitin specific peptidase 5 (isopeptidase T); Ubiquitin specific peptidase 5; Ubiquitin specific processing protease 5; Ubiquitin specific protease 5 (isopeptidase T); Ubiquitin specific protease 5 (ubiquitin isopeptidase T); Ubiquitin thioesterase 5; Ubiquitin thiolesterase 5; Ubiquitin-specific-processing protease 5; UBP5_HUMAN; Usp5
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
  • 基因功能參考文獻(xiàn)：
    1. USP5 regulates c-Maf stability and multiple myeloma cell survival. PMID: 28933784
    2. study demonstrates that USP5 plays a critical role in tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein, and provides a rationale for USP5 being a potential therapeutic approach against pancreatic ductal adenocarcinoma PMID: 28807830
    3. Taken together, our study for the first time clarified that the E3 ligase Smurf1 regulates USP5 protein stability and USP5-mediated TNF-alpha production through the ubiquitin proteasome pathway. PMID: 27133717
    4. Used IM-MS analysis to study conformational flexibility of the multidomain deubiquitinating enzyme ubiquitin specific protease 5 (USP5). PMID: 25641936
    5. Charge-state distribution and ion mobility analysis revealed that both mono- and tetra-ubiquitin bound to the compact conformation of USP5 only. PMID: 25970461
    6. Cellular isopeptidase T deubiquitinating enzyme disassembles free ubiquitin chains to facilitate KSHV K7 degradation. PMID: 23720098
    7. polyubiquitin chains by USP5 at sites of damage is important for efficient DSB repair PMID: 24454762
    8. Local administration of NO may prevent neointimal hyperplasia by inhibiting isopeptidase T levels and activity in the vasculature, thereby inhibiting the 26S proteasome in vascular smooth muscle cells. PMID: 23375434
    9. Production of the USP5 isoform 2 was strongly correlated with PTBP1 expression in glioblastoma tumor samples and cell lines. PMID: 21976412
    10. USP5 uses multiple zinc fluoride (ZnF)-ubiquitin binding protein (UBP) domains for substrate targeting and core catalytic function. PMID: 22283393
    11. Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome. PMID: 11771738
    12. identification of catalytic site PMID: 12435595
    13. We report the crystal structures of the zinc-finger ubiquitin binding domain (ZnF UBP) from the deubiquitinating enzyme isopeptidase T (IsoT, or USP5) alone and in complex with ubiquitin. This domain is required for optimal catalytic activation of IsoT. PMID: 16564012
    14. p53 is selectively stabilized because the unanchored polyubiquitin that accumulates after USP5 knockdown is able to compete with ubiquitinated p53 but not with Mdm2 for proteasomal recognition PMID: 19098288

    顯示更多

    收起更多

  • 蛋白家族：
    Peptidase C19 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12628

    OMIM: 601447

    KEGG: hsa:8078

    STRING: 9606.ENSP00000229268

    UniGene: Hs.631661



主站蜘蛛池模板： 人人妻人人妻人人片av| 蜜臀av无码精品人妻色欲| 少妇内射高潮福利炮| 视频在线+欧美十亚洲曰本| 欧美三級片黃色三級片黃色| 成人无码av一区二区三区| 亚洲精品无码鲁网午夜| 日本伊人精品一区二区三区| 欧美国产综合欧美视频| 人妻天天爽夜夜爽精品视频| 亚洲欧美综合精品成人网站| 人妻丰满熟妇岳av无码区hd| 自慰小少妇毛又多又黑流白浆| 人妻avav中文系列久久| 久久天天躁狠狠躁夜夜爽| 亚洲午夜成人片| 99久久久无码国产精品秋霞网 | 7777色鬼xxxx欧美色妇| 国产精品一品二区三区的使用体验| 男人女人午夜视频免费| 国产av久久久久精东av| 欧美日韩亚洲中文字幕一区二区三区| 成熟丰满熟妇av无码区| 人人妻人人澡人人爽国产| 国产成人无码视频网站在线观看| 扒开双腿疯狂进出爽爽爽视频 | 18岁日韩内射颜射午夜久久成人| 欧美人与性动交g欧美精器| 国产97色在线 | 日韩| 99精品国产福利在线观看| 亚洲人成人无码网www电影首页| 欧美性猛交ⅹxxx乱大交妖精| 乱人伦中文视频在线| 亚洲一卡2卡三卡4卡国色天香| 女人国产香蕉久久精品| 人妻精品无码一区二区三区| 午夜福利麻豆国产精品| 激情综合色综合啪啪五月丁香搜索| 亚 洲 视 频 高 清 无 码| 国产精品福利视频一区| 亚洲成a人v电影在线观看|