在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. USP5 Antibody, FITC conjugated

USP5 Antibody, FITC conjugated

  • 中文名稱：
    USP5兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA025742LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) USP5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    USP5
  • 別名：
    Deubiquitinating enzyme 5 antibody; Isopeptidase T antibody; ISOT 1 antibody; ISOT antibody; Ubiquitin carboxyl-terminal hydrolase 5 antibody; Ubiquitin isopeptidase T antibody; Ubiquitin specific peptidase 5 (isopeptidase T) antibody; Ubiquitin specific peptidase 5 antibody; Ubiquitin specific processing protease 5 antibody; Ubiquitin specific protease 5 (isopeptidase T) antibody; Ubiquitin specific protease 5 (ubiquitin isopeptidase T) antibody; Ubiquitin thioesterase 5 antibody; Ubiquitin thiolesterase 5 antibody; Ubiquitin-specific-processing protease 5 antibody; UBP5_HUMAN antibody; Usp5 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 5 protein (201-500AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
  • 基因功能參考文獻：
    1. USP5 regulates c-Maf stability and multiple myeloma cell survival. PMID: 28933784
    2. study demonstrates that USP5 plays a critical role in tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein, and provides a rationale for USP5 being a potential therapeutic approach against pancreatic ductal adenocarcinoma PMID: 28807830
    3. Taken together, our study for the first time clarified that the E3 ligase Smurf1 regulates USP5 protein stability and USP5-mediated TNF-alpha production through the ubiquitin proteasome pathway. PMID: 27133717
    4. Used IM-MS analysis to study conformational flexibility of the multidomain deubiquitinating enzyme ubiquitin specific protease 5 (USP5). PMID: 25641936
    5. Charge-state distribution and ion mobility analysis revealed that both mono- and tetra-ubiquitin bound to the compact conformation of USP5 only. PMID: 25970461
    6. Cellular isopeptidase T deubiquitinating enzyme disassembles free ubiquitin chains to facilitate KSHV K7 degradation. PMID: 23720098
    7. polyubiquitin chains by USP5 at sites of damage is important for efficient DSB repair PMID: 24454762
    8. Local administration of NO may prevent neointimal hyperplasia by inhibiting isopeptidase T levels and activity in the vasculature, thereby inhibiting the 26S proteasome in vascular smooth muscle cells. PMID: 23375434
    9. Production of the USP5 isoform 2 was strongly correlated with PTBP1 expression in glioblastoma tumor samples and cell lines. PMID: 21976412
    10. USP5 uses multiple zinc fluoride (ZnF)-ubiquitin binding protein (UBP) domains for substrate targeting and core catalytic function. PMID: 22283393
    11. Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome. PMID: 11771738
    12. identification of catalytic site PMID: 12435595
    13. We report the crystal structures of the zinc-finger ubiquitin binding domain (ZnF UBP) from the deubiquitinating enzyme isopeptidase T (IsoT, or USP5) alone and in complex with ubiquitin. This domain is required for optimal catalytic activation of IsoT. PMID: 16564012
    14. p53 is selectively stabilized because the unanchored polyubiquitin that accumulates after USP5 knockdown is able to compete with ubiquitinated p53 but not with Mdm2 for proteasomal recognition PMID: 19098288

    顯示更多

    收起更多

  • 蛋白家族：
    Peptidase C19 family
  • 數據庫鏈接：

    HGNC: 12628

    OMIM: 601447

    KEGG: hsa:8078

    STRING: 9606.ENSP00000229268

    UniGene: Hs.631661



主站蜘蛛池模板： 国产又色又爽又黄的在线观看| 国产亲子乱弄免费视频| 成在人线av无码免观看麻豆| 亚洲人成无码网站18禁10| 浪货趴办公桌～h揉秘书电影| 国产精品视频二区不卡| 欧美激情性做爰免费视频| 日本少妇裸体做爰高潮片 | 久久综合88熟人妻| 国产麻豆精品av在线观看| 国产三级农村妇女在线| 欧美又黄又大又爽a片三年片| 亚洲人成人网站在线观看| 无码人妻精品一区二区三区99不卡| 亚洲精品久久久久中文第一幕| 亚欧欧美人成视频在线| 鲁一鲁av2019在线| 国产日产久久高清欧美一区| 欧美黑人又粗又大高潮喷水| 国产精品午夜福利不卡120| 少妇极品熟妇人妻200片| 国产一性一交一伦一a片| 国产婷婷一区二区三区| 欧美日韩一卡2卡三卡4卡 乱码欧美孕交 | 无码乱肉视频免费大全合集| 99久久精品费精品国产一区二区| 最新精品香蕉在线| 加比勒色综合久久| 亚洲国产区男人本色vr| 插我一区二区在线观看| 国产-第1页-浮力影院| 国产美女被遭高潮免费网站| 欧美无人区码suv| 色婷婷久久综合中文久久蜜桃av| 精品熟女少妇a∨免费久久| 亚洲 一区二区 在线| 天天躁日日躁狠狠躁性色avq| av无码精品一区二区三区宅噜噜| 免费国产va在线观看| 国产美女裸身网站免费观看视频 | 亚洲人成无码网www|