在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. USP5 Antibody, HRP conjugated

USP5 Antibody, HRP conjugated

  • 中文名稱：
    USP5兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA025742LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) USP5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    USP5
  • 別名：
    Deubiquitinating enzyme 5 antibody; Isopeptidase T antibody; ISOT 1 antibody; ISOT antibody; Ubiquitin carboxyl-terminal hydrolase 5 antibody; Ubiquitin isopeptidase T antibody; Ubiquitin specific peptidase 5 (isopeptidase T) antibody; Ubiquitin specific peptidase 5 antibody; Ubiquitin specific processing protease 5 antibody; Ubiquitin specific protease 5 (isopeptidase T) antibody; Ubiquitin specific protease 5 (ubiquitin isopeptidase T) antibody; Ubiquitin thioesterase 5 antibody; Ubiquitin thiolesterase 5 antibody; Ubiquitin-specific-processing protease 5 antibody; UBP5_HUMAN antibody; Usp5 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 5 protein (201-500AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
  • 基因功能參考文獻：
    1. USP5 regulates c-Maf stability and multiple myeloma cell survival. PMID: 28933784
    2. study demonstrates that USP5 plays a critical role in tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein, and provides a rationale for USP5 being a potential therapeutic approach against pancreatic ductal adenocarcinoma PMID: 28807830
    3. Taken together, our study for the first time clarified that the E3 ligase Smurf1 regulates USP5 protein stability and USP5-mediated TNF-alpha production through the ubiquitin proteasome pathway. PMID: 27133717
    4. Used IM-MS analysis to study conformational flexibility of the multidomain deubiquitinating enzyme ubiquitin specific protease 5 (USP5). PMID: 25641936
    5. Charge-state distribution and ion mobility analysis revealed that both mono- and tetra-ubiquitin bound to the compact conformation of USP5 only. PMID: 25970461
    6. Cellular isopeptidase T deubiquitinating enzyme disassembles free ubiquitin chains to facilitate KSHV K7 degradation. PMID: 23720098
    7. polyubiquitin chains by USP5 at sites of damage is important for efficient DSB repair PMID: 24454762
    8. Local administration of NO may prevent neointimal hyperplasia by inhibiting isopeptidase T levels and activity in the vasculature, thereby inhibiting the 26S proteasome in vascular smooth muscle cells. PMID: 23375434
    9. Production of the USP5 isoform 2 was strongly correlated with PTBP1 expression in glioblastoma tumor samples and cell lines. PMID: 21976412
    10. USP5 uses multiple zinc fluoride (ZnF)-ubiquitin binding protein (UBP) domains for substrate targeting and core catalytic function. PMID: 22283393
    11. Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome. PMID: 11771738
    12. identification of catalytic site PMID: 12435595
    13. We report the crystal structures of the zinc-finger ubiquitin binding domain (ZnF UBP) from the deubiquitinating enzyme isopeptidase T (IsoT, or USP5) alone and in complex with ubiquitin. This domain is required for optimal catalytic activation of IsoT. PMID: 16564012
    14. p53 is selectively stabilized because the unanchored polyubiquitin that accumulates after USP5 knockdown is able to compete with ubiquitinated p53 but not with Mdm2 for proteasomal recognition PMID: 19098288

    顯示更多

    收起更多

  • 蛋白家族：
    Peptidase C19 family
  • 數據庫鏈接：

    HGNC: 12628

    OMIM: 601447

    KEGG: hsa:8078

    STRING: 9606.ENSP00000229268

    UniGene: Hs.631661



主站蜘蛛池模板： 天天鲁在视频在线观看| 亚洲精品无码av中文字幕电影网站| 国产成人亚洲日韩欧美| 中国猛少妇色xxxxx| 一 级 黄 色 片免费网站| 无码人妻精品一区二区三| 免费无码又爽又刺激高潮的动态图| 无码专区6080yy国产电影| 久久av无码αv高潮αv喷吹| 国产精品日日做人人爱| 中文字幕乱人伦高清视频| 久久综合色老色| .精品久久久麻豆国产精品| 色欲精品国产一区二区三区av | 五月天天天综合精品无码| 国产精品综合色区在线观看| 天天狠天天天天透在线 | 国产肉丝袜视频在线观看| 欧美三级a做爰在线观看| 全球av集中精品导航福利| 在线精品视频一区二区| 好紧好爽好深再快点av在线| 久久精品国产成人av| 久久精品中文騷妇女内射| 国产精品高潮呻吟av久久| 久久综合九色综合国产| 极品少妇xxxx| 麻豆国产在线精品国偷产拍| 2020国产成人精品影视| 无码丰满熟妇juliaann与黑人| 色综合av综合无码综合网站| 秋霞无码久久久精品交换| 久久久亚洲精品一区二区三区 | 偷看少妇自慰xxxx| 欧美日韩人成视频在线播放| 国产精品无码一本二本三本色 | 国产成人免费永久播放视频平台| 亚洲中文字幕无码日韩精品| 亚洲综合av永久无码精品一区二区| 亚洲综合最新无码专区| 国产精品自在拍一区二区不卡|