在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human U1 small nuclear ribonucleoprotein A (SNRPA)

  • 中文名稱:
    人SNRPA重組蛋白
  • 貨號:
    CSB-BP022327HU
  • 規(guī)格:
    ¥1902
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    SNRPA
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    Baculovirus
  • 分子量:
    36.8 kDa
  • 表達(dá)區(qū)域:
    2-282aa
  • 氨基酸序列
    AVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFVERDRKREKRKPKSQETPATKKAVQGGGATPVVGAVQGPVPGMPPMTQAPRIMHHMPGQPPYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEETNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKISFAKK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.
  • 基因功能參考文獻(xiàn):
    1. SNRPA may contribute to GC progression via NGF and could be a prognostic biomarker for GC. PMID: 30039889
    2. p65 activation triggered by TCR signaling could promote SNRPA transcription and 3' UTR shortening of STAT5B. Thus we propose that the alternative polyadenylation switching of STAT5B induced by TCR activation is mediated by SNRPA. PMID: 28954886
    3. a new mechanism for regulating SMN levels and provides new insight into the roles of U1A in 3' processing of mRNAs. PMID: 24362020
    4. An analysis of the kinetic data suggests three phases of U1A-SL2 RNA complex dissociation with time scales of approximately 100 mus, approximately 50 ms, and approximately 2 s. We propose that the first step of dissociation is a fast rearrangement of the complex to form a loosely bound complex. PMID: 21419778
    5. structural analysis of U1A protein-stem loop 2 RNA recognition PMID: 21384338
    6. study shows that the yellow fever virus (YFV) NS5 protein is able to interact with U1A, a protein involved in splicing and polyadenylation; a region between amino acids 368 and 448 was identified as the site of interaction of the NS5 protein with U1A PMID: 21298455
    7. 13)C NMR relaxation studies of base and ribose dynamics for the RNA internal loop target of human U1A protein located within the 3'-untranslated region (3'-UTR) of the mRNA coding for U1A itself PMID: 15890361
    8. Identification of PSF, p54(nrb), PTB, and U1A as proteins specifically bound to the COX-2 polyadenylation signal upstream sequence elements . PMID: 17507659
    9. Functional U1A site in a cellular gene and of a single gene containing two dissimilar elements that inhibit nuclear polyadenylation. PMID: 17942741

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus.
  • 蛋白家族:
    RRM U1 A/B'' family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11151

    OMIM: 182285

    KEGG: hsa:6626

    STRING: 9606.ENSP00000243563

    UniGene: Hs.466775



主站蜘蛛池模板: 女女女女女裸体处开bbb| 中国熟妇毛多多裸交视频| 中美日韩毛片免费播放| 九九综合va免费看| 国产内射爽爽大片视频社区在线| 亚洲中国精品精华液| 亲嘴扒胸摸屁股激烈网站| 女人被狂躁到高潮视频免费软件| 亚洲三区在线观看内射后入| 97se狠狠狠狠狼鲁亚洲综合色| 国产精品aⅴ视频在线播放| 最近日本免费观看高清视频| 狠狠热精品免费视频| 亚洲-av-无限看| 亚洲精品一区二区中文字幕| 少妇精品无码一区二区免费视频| 娇妻玩4p被三个男人伺候电影| 亚洲日韩高清在线亚洲专区| 国产白丝精品爽爽久久久久久蜜臀| 天天做日日做天天添天天欢公交车 | 久久国产成人免费网站777| 中国丰满熟妇av| 丝袜美腿一区二区三区| 亚洲欧美色一区二区三区| 亚洲色无码专线精品观看| 激情国产av做激情国产爱| 国产精品 视频一区 二区三区| 国产综合精品一区二区三区| 两性色午夜视频免费播放| 久久久久久好爽爽久久| 精品国产人妻一区二区三区| 国产黑色丝袜在线观看下| a∨在线视频播放| 国产成年无码v片在线| 午夜成人亚洲理伦片在线观看| 亚洲va久久久噜噜噜久久男同| 国产av无码精品色午夜| 性视频播放免费视频| 狠狠做深爱婷婷丁香综合 | 99久久伊人精品综合观看| 无码国产69精品久久久久孕妇|