在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Tubulin-specific chaperone D (TBCD), partial

Recombinant Human Tubulin-specific chaperone D (TBCD), partial

  • 中文名稱：
    人TBCD重組蛋白
  • 貨號(hào)：
    CSB-YP883599HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TBCD重組蛋白
  • 貨號(hào)：
    CSB-EP883599HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TBCD重組蛋白
  • 貨號(hào)：
    CSB-EP883599HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TBCD重組蛋白
  • 貨號(hào)：
    CSB-BP883599HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TBCD重組蛋白
  • 貨號(hào)：
    CSB-MP883599HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TBCD
  • Uniprot No.：
  • 別名：
    Beta tubulin cofactor D; Beta-tubulin cofactor D; KIAA0988; SSD 1; SSD-1; SSD1; tbcd; TBCD_HUMAN; tfcD; Tubulin folding cofactor D; Tubulin specific chaperone D; Tubulin-folding cofactor D; Tubulin-specific chaperone D
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis.
  • 基因功能參考文獻(xiàn)：
    1. TBCD protein was localized in the middle region and in the tail of the sperm while in the oocyte the localization was cytosolic. PMID: 28583220
    2. Authors conclude that TBCD is a novel functional contributor to the mammalian cerebral cortex development, and that the pathological mechanism resulting from the mutations we describe is likely to involve compromised interactions with one or more TBCD-interacting effectors that influence the dynamics and behaviour of the neuronal cytoskeleton. PMID: 28158450
    3. conclude that the TBCD*ARL2*beta-tubulin complex represents a functional intermediate in the beta-tubulin folding pathway whose activity is regulated by the cycling of nucleotides on ARL2 PMID: 28970104
    4. Results identified ARL2 and TBCD, as important in tubulin folding and microtubule dynamics. Both ARL2 and TBCD also localize to centrosomes. [review] PMID: 27400436
    5. variants. We identified two candidate homozygous missense variants, R942Q in the tubulin-folding cofactor D (TBCD) gene and H250Q in the bromo-adjacent homology domain and coiled-coil containing 1 (BAHCC1) gene, located on chromosome 17q25.3 with an interval of 1.4 Mbp. PMID: 27928163
    6. Intractable epilepsy, intellectual disability and acquired microcephaly, and cortical atrophy and thinned corpus callosum as major MRI features, caused by biallelic variants in TBCD. PMID: 27807845
    7. findings establish that defective TBCD function underlies a recognizable encephalopathy and drives accelerated microtubule polymerization and enhanced microtubule stability, underscoring an additional cause of altered microtubule dynamics with impact on neuronal function and survival in the developing brain PMID: 27666370
    8. Defects of microtubule formation caused by TBCD mutations may underlie the pathomechanism of a neurodegenerative encephalopathy. PMID: 27666374
    9. genetic polymorphism is associated with bone mineral accretion in children with asthma receiving intermittent oral corticosteroids PMID: 26025128
    10. Data show that bovine and human TBCD have functionally identical roles in tubulin heterodimer assembly, and that the inability of human TBCD to disrupt microtubule integrity can be overcome by siRNA-mediated suppression of expression of Arl2. PMID: 20740604
    11. provides first evidence that beta-tubulin cofactor D plays a role in cells independent of its presumed role in folding tubulin heterodimers PMID: 17704193
    12. Cofactor D functions as a centrosomal protein and is required for the recruitment of the gamma-tubulin ring complex at centrosomes and organization of the mitotic spindle PMID: 18171676

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Encephalopathy, progressive, early-onset, with brain atrophy and thin corpus callosum (PEBAT)
  • 亞細(xì)胞定位：
    Cell junction, tight junction. Lateral cell membrane. Cytoplasm. Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    TBCD family
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11581

    OMIM: 604649

    KEGG: hsa:6904

    STRING: 9606.ENSP00000347719

    UniGene: Hs.464391



主站蜘蛛池模板： 四虎永久在线精品884aa| 在线观看的网站| 国产亚洲精品久久yy5099| 欧美成aⅴ人高清免费观看| 初尝黑人嗷嗷叫中文字幕| 国产自偷自偷免费一区| 久9re热视频这里只有精品| 水蜜桃av无码一区二区| 草裙社区精品视频三区免费看 | 国产亚洲精品第一综合另类| 上司人妻互换中文字幕| 国色天香成人网| 又湿又黄裸乳漫画无遮挡网站| 色哟哟最新在线观看入口| 无码成a毛片免费| 深夜福利啪啪片| 2021国产精品国产精华| 国产亚洲欧洲aⅴ综合一区| 国产成人精品亚洲线观看| 狠狠色丁香久久婷婷综合图片| 五月综合色婷婷在线观看| 美国人性欧美xxxx| 在线a亚洲视频播放在线观看| 亚洲中文字幕精品久久| 99久久国产综合精品女图图等你 | 西西人体大胆4444www| 韩国无码色视频在线观看| 精品av综合导航| 久久久久无码精品国产不卡| 国产精品成人片在线观看| 久久只精品99品免费久23| 日韩精品一区二区三区在线观看| 国产成人麻豆精品午夜福利在线| 亚洲一线产区二线产区分布| 中文字幕人成人乱码亚洲电影| 国产精品久久久久久久| 欧美xxxx做受欧美69| 99精品国产一区二区三区a片| 凹凸国产熟女精品视频app| 亚洲高清有码中文字| 亚洲综合欧美在线一区在线播放|