在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Tubulin-specific chaperone D (TBCD), partial

Recombinant Human Tubulin-specific chaperone D (TBCD), partial

  • 中文名稱：
    人TBCD重組蛋白
  • 貨號(hào)：
    CSB-YP883599HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TBCD重組蛋白
  • 貨號(hào)：
    CSB-EP883599HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TBCD重組蛋白
  • 貨號(hào)：
    CSB-EP883599HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TBCD重組蛋白
  • 貨號(hào)：
    CSB-BP883599HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TBCD重組蛋白
  • 貨號(hào)：
    CSB-MP883599HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TBCD
  • Uniprot No.：
  • 別名：
    Beta tubulin cofactor D; Beta-tubulin cofactor D; KIAA0988; SSD 1; SSD-1; SSD1; tbcd; TBCD_HUMAN; tfcD; Tubulin folding cofactor D; Tubulin specific chaperone D; Tubulin-folding cofactor D; Tubulin-specific chaperone D
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis.
  • 基因功能參考文獻(xiàn)：
    1. TBCD protein was localized in the middle region and in the tail of the sperm while in the oocyte the localization was cytosolic. PMID: 28583220
    2. Authors conclude that TBCD is a novel functional contributor to the mammalian cerebral cortex development, and that the pathological mechanism resulting from the mutations we describe is likely to involve compromised interactions with one or more TBCD-interacting effectors that influence the dynamics and behaviour of the neuronal cytoskeleton. PMID: 28158450
    3. conclude that the TBCD*ARL2*beta-tubulin complex represents a functional intermediate in the beta-tubulin folding pathway whose activity is regulated by the cycling of nucleotides on ARL2 PMID: 28970104
    4. Results identified ARL2 and TBCD, as important in tubulin folding and microtubule dynamics. Both ARL2 and TBCD also localize to centrosomes. [review] PMID: 27400436
    5. variants. We identified two candidate homozygous missense variants, R942Q in the tubulin-folding cofactor D (TBCD) gene and H250Q in the bromo-adjacent homology domain and coiled-coil containing 1 (BAHCC1) gene, located on chromosome 17q25.3 with an interval of 1.4 Mbp. PMID: 27928163
    6. Intractable epilepsy, intellectual disability and acquired microcephaly, and cortical atrophy and thinned corpus callosum as major MRI features, caused by biallelic variants in TBCD. PMID: 27807845
    7. findings establish that defective TBCD function underlies a recognizable encephalopathy and drives accelerated microtubule polymerization and enhanced microtubule stability, underscoring an additional cause of altered microtubule dynamics with impact on neuronal function and survival in the developing brain PMID: 27666370
    8. Defects of microtubule formation caused by TBCD mutations may underlie the pathomechanism of a neurodegenerative encephalopathy. PMID: 27666374
    9. genetic polymorphism is associated with bone mineral accretion in children with asthma receiving intermittent oral corticosteroids PMID: 26025128
    10. Data show that bovine and human TBCD have functionally identical roles in tubulin heterodimer assembly, and that the inability of human TBCD to disrupt microtubule integrity can be overcome by siRNA-mediated suppression of expression of Arl2. PMID: 20740604
    11. provides first evidence that beta-tubulin cofactor D plays a role in cells independent of its presumed role in folding tubulin heterodimers PMID: 17704193
    12. Cofactor D functions as a centrosomal protein and is required for the recruitment of the gamma-tubulin ring complex at centrosomes and organization of the mitotic spindle PMID: 18171676

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Encephalopathy, progressive, early-onset, with brain atrophy and thin corpus callosum (PEBAT)
  • 亞細(xì)胞定位：
    Cell junction, tight junction. Lateral cell membrane. Cytoplasm. Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    TBCD family
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11581

    OMIM: 604649

    KEGG: hsa:6904

    STRING: 9606.ENSP00000347719

    UniGene: Hs.464391



主站蜘蛛池模板： 2020久久超碰国产精品最新| 色综合久久中文娱乐网| 成人午夜亚洲精品无码区毛片| 人妻.中文字幕无码| 永久免费观看国产裸体美女| 精品少妇人妻av免费久久久| 国产国拍精品av在线观看| 国产精品国产三级在线... | 国产欧美日韩| 国产爆乳无码av在线播放| 国产精品亚洲a∨天堂不卡| 欧洲熟妇精品视频| 人妻系列无码专区久久五月天| 久久综合色_综合色88| 亚洲国产婷婷综合在线精品| 成在人线av无码免费| 国产亚洲精品久久久久秋霞不卡| 热99re久久国超精品首页| 欧美牲交a欧美牲交aⅴ免费| 国产美女在线精品免费观看| 国产亚洲精品久久久久久国| 国产精品久久久久无码av1| 亚洲人成无码网站久久99热国产| 中文字幕一区二区三区精华液 | 呻吟国产av久久一区二区| 午夜成人性刺激免费视频| 国产婷婷色一区二区三区| 狠狠躁日日躁夜夜躁2022麻豆| 天天摸天天摸天天天天看| 无套内射在线观看theporn| 日产一区日产2区| 精品高朝久久久久9999| 成人福利国产精品视频| 污污内射久久一区二区欧美日韩| 狠狠色噜噜狼狼狼色综合久| 成人无码av网站在线观看 | 高潮喷吹一区二区在线观看| 草草网站影院白丝内射| 国产熟妇久久777777| 欧美成人va免费大片视频| 忘忧草社区在线资源www|