在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TBCD Antibody

  • 中文名稱:
    TBCD兔多克隆抗體
  • 貨號(hào):
    CSB-PA023229GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    TBCD
  • 別名:
    Beta tubulin cofactor D antibody; Beta-tubulin cofactor D antibody; KIAA0988 antibody; SSD 1 antibody; SSD-1 antibody; SSD1 antibody; tbcd antibody; TBCD_HUMAN antibody; tfcD antibody; Tubulin folding cofactor D antibody; Tubulin specific chaperone D antibody; Tubulin-folding cofactor D antibody; Tubulin-specific chaperone D antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TBCD
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis.
  • 基因功能參考文獻(xiàn):
    1. TBCD protein was localized in the middle region and in the tail of the sperm while in the oocyte the localization was cytosolic. PMID: 28583220
    2. Authors conclude that TBCD is a novel functional contributor to the mammalian cerebral cortex development, and that the pathological mechanism resulting from the mutations we describe is likely to involve compromised interactions with one or more TBCD-interacting effectors that influence the dynamics and behaviour of the neuronal cytoskeleton. PMID: 28158450
    3. conclude that the TBCD*ARL2*beta-tubulin complex represents a functional intermediate in the beta-tubulin folding pathway whose activity is regulated by the cycling of nucleotides on ARL2 PMID: 28970104
    4. Results identified ARL2 and TBCD, as important in tubulin folding and microtubule dynamics. Both ARL2 and TBCD also localize to centrosomes. [review] PMID: 27400436
    5. variants. We identified two candidate homozygous missense variants, R942Q in the tubulin-folding cofactor D (TBCD) gene and H250Q in the bromo-adjacent homology domain and coiled-coil containing 1 (BAHCC1) gene, located on chromosome 17q25.3 with an interval of 1.4 Mbp. PMID: 27928163
    6. Intractable epilepsy, intellectual disability and acquired microcephaly, and cortical atrophy and thinned corpus callosum as major MRI features, caused by biallelic variants in TBCD. PMID: 27807845
    7. findings establish that defective TBCD function underlies a recognizable encephalopathy and drives accelerated microtubule polymerization and enhanced microtubule stability, underscoring an additional cause of altered microtubule dynamics with impact on neuronal function and survival in the developing brain PMID: 27666370
    8. Defects of microtubule formation caused by TBCD mutations may underlie the pathomechanism of a neurodegenerative encephalopathy. PMID: 27666374
    9. genetic polymorphism is associated with bone mineral accretion in children with asthma receiving intermittent oral corticosteroids PMID: 26025128
    10. Data show that bovine and human TBCD have functionally identical roles in tubulin heterodimer assembly, and that the inability of human TBCD to disrupt microtubule integrity can be overcome by siRNA-mediated suppression of expression of Arl2. PMID: 20740604
    11. provides first evidence that beta-tubulin cofactor D plays a role in cells independent of its presumed role in folding tubulin heterodimers PMID: 17704193
    12. Cofactor D functions as a centrosomal protein and is required for the recruitment of the gamma-tubulin ring complex at centrosomes and organization of the mitotic spindle PMID: 18171676

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Encephalopathy, progressive, early-onset, with brain atrophy and thin corpus callosum (PEBAT)
  • 亞細(xì)胞定位:
    Cell junction, tight junction. Lateral cell membrane. Cytoplasm. Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    TBCD family
  • 組織特異性:
    Ubiquitously expressed.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 11581

    OMIM: 604649

    KEGG: hsa:6904

    STRING: 9606.ENSP00000347719

    UniGene: Hs.464391



主站蜘蛛池模板: 亚洲国产成人av在线观看| 欧美人伦禁忌dvd放荡欲情| 色综合久久一区二区三区| 10000部拍拍拍免费视频| 一本一道vs无码中文字幕| 亚洲国产日韩在线人成蜜芽| av无码不卡一区二区三区| 黄网在线观看免费网站| 人人妻人人澡人人爽欧美一区九九 | 色多多性虎精品无码av| 午夜福利麻豆国产精品| 亚洲欧洲久久av| 少妇人妻丰满做爰xxx| 日日噜噜噜夜夜爽爽狠狠视频| 人妻精品制服丝袜久久久| 中文字幕在线不卡精品视频99| 国产精品久久久久9999高清| 久久精品丝袜高跟鞋| 无码国产一区二区三区四区| 羞国产在线拍揄自揄视频| 亚洲国产精品成人久久| 亚洲国产精品一区二区久久| 亚色九九九全国免费视频| 国产成人精品av| 亚洲成av人片一区二区密柚| 午夜国人精品av免费看| 日韩一区二区三区四区区区| 国内女人喷潮完整视频| 99久无码中文字幕一本久道| 亚洲国产成人久久一区久久| 精品一区二区三区无码av久久| 亚洲乱码精品久久久久..| 狠人干练合综合网| 国产第一页浮力影院草草| 中文字幕无码av波多野吉衣| 亚洲卡1卡2卡新区网站| 成人网站免费高清视频在线观看| 东北女人啪啪对白| 日本三级理论久久人妻电影| 中国做爰国产精品视频| 久久av无码精品人妻出轨|