在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Trinucleotide repeat-containing gene 6A protein (TNRC6A), partial

Recombinant Human Trinucleotide repeat-containing gene 6A protein (TNRC6A), partial

  • 中文名稱：
    人TNRC6A重組蛋白
  • 貨號：
    CSB-YP839859HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TNRC6A重組蛋白
  • 貨號：
    CSB-EP839859HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TNRC6A重組蛋白
  • 貨號：
    CSB-EP839859HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TNRC6A重組蛋白
  • 貨號：
    CSB-BP839859HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TNRC6A重組蛋白
  • 貨號：
    CSB-MP839859HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TNRC6A
  • Uniprot No.：
  • 別名：
    CAG repeat protein 26; CAGH26; DKFZp666E117; EDIE ; EMSY interactor protein; FLJ22043; Glycine tryptophan protein of 182 kDa; Glycine-tryptophan protein of 182 kDa; GW1; GW182; GW182 autoantigen; Hypothetical protein DKFZp566M143 ; KIAA1460; MGC75384; OTTHUMP00000122485; OTTHUMP00000195164; OTTHUMP00000195165; Protein GW1; TNR6A_HUMAN; TNRC 6A; TNRC6; Tnrc6a; Trinucleotide repeat containing 6A; Trinucleotide repeat containing gene 6A protein; Trinucleotide repeat-containing gene 6A protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.
  • 基因功能參考文獻：
    1. that the interactions observed between TNRC6A and importin-alpha are conserved between mouse and human complexes. Our results highlight the ability of monopartite cNLS sequences to maximise contacts at the importin-alpha major binding site, as well as regions outside the main binding cavities PMID: 28837617
    2. The results suggest that overexpressed Dcp1a and GW182 can form different cytoplasmic aggregates and play distinct biological roles in the miRNA pathway. PMID: 28488892
    3. The results indicate that TNRC6A subcellular localization is substantially controlled by the interaction with Argonaute proteins. PMID: 26446993
    4. TRIM65 relieves miRNA-driven suppression of mRNA expression through ubiquitination and subsequent degradation of TNRC6. PMID: 24778252
    5. we have identified a new function of GW182 in protecting mature miRNA from being degraded by interacting with Argonaute (AGO) proteins PMID: 23090477
    6. HSP90 and GW182 are important factors in the pathomechanism of alcohol-induced augmentation of HCV replication. PMID: 22898980
    7. GW182 plays a critical role in miRNA-mediated gene silencing. (Review) PMID: 23224966
    8. GW182 proteins function as scaffold proteins for the assembly of the multiprotein complex that silences miRNA targets. (Review) PMID: 23224969
    9. 28.6% of patients containing autoantibodies to the trinucleotide repeat region of the TNRC6A were shown to have a single nucleotide polymorphism at c.344C>A in the CAG/CCA/G-rich region of TNRC6A. PMID: 23224974
    10. Sinse Argonaute and GW182 are the core proteins of the RNA-silencing complex (RISC), it seems appropriate to suggest that the RISC is the main target of human autoantibodies. (Review) PMID: 23224975
    11. Analysis of the results suggested that TNRC6A plays an important role in navigating Argonaute protein into the nucleus to lead miRNA-mediated gene silencing. PMID: 23150874
    12. Mammalian GW proteins have distinctive functions in the miRNA pathway, with GW220/TNGW1 being essential for aggregation and formation of GW/P bodies that sequester and stabilize translationally repressed target mRNA. PMID: 22891262
    13. Data demonstrate that in human and Drosophila melanogaster cells, the critical repressive features of both the N-terminal and C-terminal effector domains of GW182 proteins are Gly/Ser/Thr-Trp (G/S/TW) or Trp-Gly/Ser/Thr (WG/S/T) motifs. PMID: 21984184
    14. Data suggest that GW182 serves as both a platform that recruits deadenylases and as a deadenylase coactivator that facilitates the removal of the poly(A) tail by CCR4-NOT. PMID: 21984185
    15. Alanine substitution showed that GW/WG motifs in Delta12 (Delta12a, amino acids 896-1045) were important for the silencing activity of GW182. PMID: 21131274
    16. GW ribonucleoprotein complex is involved in the posttranscriptional regulation of gene expression PMID: 11950943
    17. gene knockdown of GW182 led to the disappearance of GW bodies demonstrating that GW182 is a critical component of GW bodies PMID: 15494374
    18. data support a model in which GW182 and/or the microenvironment of the cytoplasmic GWBs contribute to the RNA-induced silencing complex and to RNA silencing PMID: 16284622
    19. results support a functional link between GW182 and the ability of a microRNA to repress expression of a target mRNA PMID: 16284623
    20. A novel 210-kDa isoform of human GW182, provisionally named trinucleotide GW1 (TNGW1)was reported.TNGW1 was expressed independently of GW182 and was present in human testis and various human cancer cells. PMID: 19056672
    21. Our findings indicate that TNRC6A, is recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein PMID: 19383768

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, P-body.
  • 蛋白家族：
    GW182 family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 11969

    OMIM: 610739

    KEGG: hsa:27327

    STRING: 9606.ENSP00000379144

    UniGene: Hs.655057



主站蜘蛛池模板： 日韩av无码成人无码免费| 国产强伦姧在线观看无码| 欧美激性欧美激情在线| 日本少妇寂寞少妇aaa| 亚洲精品第一区二区三区| 蜜桃视频无码区在线观看| 免费人成在线观看视频播放| 97在线精品视频免费| 国产精品午夜福利麻豆| 成年动漫18禁无码3d动漫| 热99re久久精品这里都是精品免费 | 欧美xxxx做受性欧美88| 精品欧洲av无码一区二区三区| 欧美日韩不卡视频合集| 真实国产精品视频400部| 国产成人综合久久免费导航| 国产精品久久久久久久久久久久人四虎 | 97精品国自产在线偷拍| 精品无码成人网站久久久久久| 亚洲国产精久久久久久久| www亚洲精品少妇裸乳一区二区| 久久久久久毛片免费播放| av无码久久久久不卡蜜桃| 国产激情综合在线看| 亚洲成av人片在线播放无码| 欧美乱妇高清无乱码在线观看| 中国熟妇牲交视频免费| 五月色婷婷丁香无码三级 | 久久精品国产精品亚洲38| 欧美性受xxxx狂喷水| 国产98色在线 | 国产| 2018年亚洲欧美在线v| 久拍国产在线观看| 婷婷网色偷偷亚洲男人甘肃| 国产黄a三级三级三级| 天堂网www在线资源中文| 欧洲 亚洲 国产图片综合| 国产精品自在拍首页视频8| 波多野美乳人妻hd电影欧美| 好大好湿好硬顶到了好爽视频| 国产精品尹人在线观看|