在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TNRC6A Antibody, FITC conjugated

  • 中文名稱:
    TNRC6A兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA839859LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) TNRC6A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TNRC6A
  • 別名:
    CAG repeat protein 26 antibody; CAGH26 antibody; DKFZp666E117 antibody; EDIE antibody; EMSY interactor protein antibody; FLJ22043 antibody; Glycine tryptophan protein of 182 kDa antibody; Glycine-tryptophan protein of 182 kDa antibody; GW1 antibody; GW182 antibody; GW182 autoantigen antibody; Hypothetical protein DKFZp566M143 antibody; KIAA1460 antibody; MGC75384 antibody; OTTHUMP00000122485 antibody; OTTHUMP00000195164 antibody; OTTHUMP00000195165 antibody; Protein GW1 antibody; TNR6A_HUMAN antibody; TNRC 6A antibody; TNRC6 antibody; Tnrc6a antibody; Trinucleotide repeat containing 6A antibody; Trinucleotide repeat containing gene 6A protein antibody; Trinucleotide repeat-containing gene 6A protein antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Trinucleotide repeat-containing gene 6A protein (1-161AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.
  • 基因功能參考文獻:
    1. that the interactions observed between TNRC6A and importin-alpha are conserved between mouse and human complexes. Our results highlight the ability of monopartite cNLS sequences to maximise contacts at the importin-alpha major binding site, as well as regions outside the main binding cavities PMID: 28837617
    2. The results suggest that overexpressed Dcp1a and GW182 can form different cytoplasmic aggregates and play distinct biological roles in the miRNA pathway. PMID: 28488892
    3. The results indicate that TNRC6A subcellular localization is substantially controlled by the interaction with Argonaute proteins. PMID: 26446993
    4. TRIM65 relieves miRNA-driven suppression of mRNA expression through ubiquitination and subsequent degradation of TNRC6. PMID: 24778252
    5. we have identified a new function of GW182 in protecting mature miRNA from being degraded by interacting with Argonaute (AGO) proteins PMID: 23090477
    6. HSP90 and GW182 are important factors in the pathomechanism of alcohol-induced augmentation of HCV replication. PMID: 22898980
    7. GW182 plays a critical role in miRNA-mediated gene silencing. (Review) PMID: 23224966
    8. GW182 proteins function as scaffold proteins for the assembly of the multiprotein complex that silences miRNA targets. (Review) PMID: 23224969
    9. 28.6% of patients containing autoantibodies to the trinucleotide repeat region of the TNRC6A were shown to have a single nucleotide polymorphism at c.344C>A in the CAG/CCA/G-rich region of TNRC6A. PMID: 23224974
    10. Sinse Argonaute and GW182 are the core proteins of the RNA-silencing complex (RISC), it seems appropriate to suggest that the RISC is the main target of human autoantibodies. (Review) PMID: 23224975
    11. Analysis of the results suggested that TNRC6A plays an important role in navigating Argonaute protein into the nucleus to lead miRNA-mediated gene silencing. PMID: 23150874
    12. Mammalian GW proteins have distinctive functions in the miRNA pathway, with GW220/TNGW1 being essential for aggregation and formation of GW/P bodies that sequester and stabilize translationally repressed target mRNA. PMID: 22891262
    13. Data demonstrate that in human and Drosophila melanogaster cells, the critical repressive features of both the N-terminal and C-terminal effector domains of GW182 proteins are Gly/Ser/Thr-Trp (G/S/TW) or Trp-Gly/Ser/Thr (WG/S/T) motifs. PMID: 21984184
    14. Data suggest that GW182 serves as both a platform that recruits deadenylases and as a deadenylase coactivator that facilitates the removal of the poly(A) tail by CCR4-NOT. PMID: 21984185
    15. Alanine substitution showed that GW/WG motifs in Delta12 (Delta12a, amino acids 896-1045) were important for the silencing activity of GW182. PMID: 21131274
    16. GW ribonucleoprotein complex is involved in the posttranscriptional regulation of gene expression PMID: 11950943
    17. gene knockdown of GW182 led to the disappearance of GW bodies demonstrating that GW182 is a critical component of GW bodies PMID: 15494374
    18. data support a model in which GW182 and/or the microenvironment of the cytoplasmic GWBs contribute to the RNA-induced silencing complex and to RNA silencing PMID: 16284622
    19. results support a functional link between GW182 and the ability of a microRNA to repress expression of a target mRNA PMID: 16284623
    20. A novel 210-kDa isoform of human GW182, provisionally named trinucleotide GW1 (TNGW1)was reported.TNGW1 was expressed independently of GW182 and was present in human testis and various human cancer cells. PMID: 19056672
    21. Our findings indicate that TNRC6A, is recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein PMID: 19383768

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, P-body.
  • 蛋白家族:
    GW182 family
  • 組織特異性:
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11969

    OMIM: 610739

    KEGG: hsa:27327

    STRING: 9606.ENSP00000379144

    UniGene: Hs.655057



主站蜘蛛池模板: 亚洲欧洲成人a∨在线观看| 久久精品超碰av无码| 宅宅午夜无码一区二区三区| 免费午夜理论不卡| 中文国产成人精品久久app| 国产精品v欧美精品v日韩精品| 日韩va中文字幕无码电影| 精品国产乱码久久久久软件| 无码一区二区三区老色鬼| 日本亚州视频在线八a| 日韩精品成人一区二区三区 | 国产精品igao视频| 亚洲国产婷婷香蕉久久久久久| 亚洲视频无码高清在线| 国内久久婷婷六月综合欲色啪| 久久久亚洲精品一区二区三区浴池| 强奷人妻日本中文字幕| 亚洲偷自拍国综合色帝国| 中文字幕久久精品一区二区三区| 无遮挡很爽很污很黄的网站| 亚洲人成电影网站色www| 国产精品久久久久永久免费看| 人妻无码一区二区三区tv| 天堂网www天堂资源网| 伊人久久大香线蕉综合中文字幕 | 国产成人精品一区二区视频| 国产精品玖玖玖在线| 再深点灬舒服灬太大了网站| 狠狠色狠狠色综合久久| 久久九九兔免费精品6| 久久精品无码一区二区www| 日本亚洲色大成网站www久久| 亚洲色大成网站www永久网站| 亚洲色大成网站在线| 好爽好湿好硬好大免费视频| 在线看片福利无码网址| 日本免费视频| 亚洲人成77在线播放网站 | 亚洲精品国偷自产在线| 国产麻豆放荡av剧情演绎| 无码手机线免费观看|