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  4. Recombinant Human Transmembrane prostate androgen-induced protein (PMEPA1), partial

Recombinant Human Transmembrane prostate androgen-induced protein (PMEPA1), partial

  • 中文名稱：
    人PMEPA1重組蛋白
  • 貨號(hào)：
    CSB-YP822170HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PMEPA1重組蛋白
  • 貨號(hào)：
    CSB-EP822170HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PMEPA1重組蛋白
  • 貨號(hào)：
    CSB-EP822170HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PMEPA1重組蛋白
  • 貨號(hào)：
    CSB-BP822170HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PMEPA1重組蛋白
  • 貨號(hào)：
    CSB-MP822170HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PMEPA1
  • Uniprot No.：
  • 別名：
    PMEPA_HUMAN; PMEPA1; Prostate transmembrane protein; androgen induced 1; Solid tumor associated 1 protein; Solid tumor-associated 1 protein; STAG1; TMEPAI; Transmembrane prostate androgen induced protein ; Transmembrane prostate androgen-induced protein; Transmembrane; prostate androgen induced RNA
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4.
  • 基因功能參考文獻(xiàn)：
    1. JHY-A007-50 mediates the downregulation of TMEPAI expression. PMID: 30069967
    2. describe recent progresses in the understanding of how the TMEPAI family physiologically contributes to cellular functions and diseases PMID: 29945215
    3. binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity. PMID: 26215835
    4. study showed that the inhibition of autophagy induced by the depletion of TMEPAI is involved in regulation of Beclin-1. PMID: 27163528
    5. these findings indicated that PMEPA1 participates in TGF-beta- and hypoxia-regulated gene expression networks in solid tumors and thereby may contribute to tumor progression. PMID: 27697531
    6. the present study suggest that the upregulation of miR19a3p expression levels contributes to tumor progression and that one of its underlying mechanisms involves inhibition of PMEPA1 expression. PMID: 27035427
    7. Sp1 up-regulated TMEPAI protein expression, as well as Sp1 promoting TMEPAI-induced cell proliferation. PMID: 27625141
    8. PMEPA1 was upregulated in breast cancer cell lines as well as in a set of clinical invasive breast ductal carcinomas. Interestingly, depletion of PMEPA1 decreased breast cancer stem cell (CSC)-enriched populations, while ectopic overexpression of PMEPA1 increased breast CSC-enriched populations. PMID: 26758191
    9. these data elaborated on the diverse activity among TCF/LEF family members with respect to the transcriptional regulation of the TMEPAI gene. PMID: 26590303
    10. Data show that over-expressed transmembrane prostate androgen-induced protein 1 (PMEPA1) can promote cell migration and maintain the mesenchymal-like morphology of breast cancer cells. PMID: 26927372
    11. Data show that silencing of PMEPA1 protein facilitates the growth of prostate cancer cells and modulates androgen receptor (AR) through NEDD4 ubiquitin protein ligase and PTEN protein. PMID: 25883222
    12. Downregulation of PMEPA1 may result in increased androgen receptor protein levels and function in cancer of the prostate cells, contributing to prostate tumorigenesis. PMID: 24694733
    13. EGF signaling collaboratively regulates TGF-beta-induced TMEPAI expression. PMID: 25482449
    14. TMEPAI is translocated on the lysosome and late endosome, and that association with Nedd4 is required for the transport of TMEPAI to the lysosome. PMID: 24933703
    15. TMEPAI promotes tumorigenic activities in lung cancer cells. PMID: 24438557
    16. The levels of TMEPAI in lung tumor tissues are very high. PMID: 23615405
    17. Differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone. PMID: 17318295
    18. Results suggest that TMEPAI functions in breast cancer as a molecular switch that converts TGF-beta from a tumor suppressor to a tumor promoter. PMID: 20610632
    19. Expression of PMEPA1 was well maintained both in colon cancer primary tumors and in colon cancer liver metastases. PMID: 12670906
    20. PMEPA1 negatively regulates growth of androgen responsive or refractory prostate cancer cells, and these functions may be mediated through the interaction of PMEPA1 with the NEDD4 protein. PMID: 12907594
    21. DNA methylation within the PMEPA1 promoter downstream sequences suggests that methylation of SP1 binding sites may also contribute to the repression of PMEPA1 gene PMID: 18174752
    22. decreased PMEPA1 expression frequently noted in prostate cancers may lead to increased AR functions and strengthen the biological role of the NEDD4-binding protein PMEPA1 in prostate cancers PMID: 18703514

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  • 亞細(xì)胞定位：
    Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
  • 蛋白家族：
    PMEPA1 family
  • 組織特異性：
    Highest expression in prostate. Also expressed in ovary.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14107

    OMIM: 606564

    KEGG: hsa:56937

    STRING: 9606.ENSP00000345826

    UniGene: Hs.517155



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