在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PMEPA1 Antibody

  • 中文名稱:
    PMEPA1兔多克隆抗體
  • 貨號:
    CSB-PA172006
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HT-29 cells, using TMEPA antibody.
    • Immunohistochemistry analysis of paraffin-embedded human prostate tissue using TMEPA antibody.
    • Immunofluorescence analysis of HUVEC cells, using TMEPA antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PMEPA1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PMEPA1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human TMEPA.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4.
  • 基因功能參考文獻(xiàn):
    1. JHY-A007-50 mediates the downregulation of TMEPAI expression. PMID: 30069967
    2. describe recent progresses in the understanding of how the TMEPAI family physiologically contributes to cellular functions and diseases PMID: 29945215
    3. binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity. PMID: 26215835
    4. study showed that the inhibition of autophagy induced by the depletion of TMEPAI is involved in regulation of Beclin-1. PMID: 27163528
    5. these findings indicated that PMEPA1 participates in TGF-beta- and hypoxia-regulated gene expression networks in solid tumors and thereby may contribute to tumor progression. PMID: 27697531
    6. the present study suggest that the upregulation of miR19a3p expression levels contributes to tumor progression and that one of its underlying mechanisms involves inhibition of PMEPA1 expression. PMID: 27035427
    7. Sp1 up-regulated TMEPAI protein expression, as well as Sp1 promoting TMEPAI-induced cell proliferation. PMID: 27625141
    8. PMEPA1 was upregulated in breast cancer cell lines as well as in a set of clinical invasive breast ductal carcinomas. Interestingly, depletion of PMEPA1 decreased breast cancer stem cell (CSC)-enriched populations, while ectopic overexpression of PMEPA1 increased breast CSC-enriched populations. PMID: 26758191
    9. these data elaborated on the diverse activity among TCF/LEF family members with respect to the transcriptional regulation of the TMEPAI gene. PMID: 26590303
    10. Data show that over-expressed transmembrane prostate androgen-induced protein 1 (PMEPA1) can promote cell migration and maintain the mesenchymal-like morphology of breast cancer cells. PMID: 26927372
    11. Data show that silencing of PMEPA1 protein facilitates the growth of prostate cancer cells and modulates androgen receptor (AR) through NEDD4 ubiquitin protein ligase and PTEN protein. PMID: 25883222
    12. Downregulation of PMEPA1 may result in increased androgen receptor protein levels and function in cancer of the prostate cells, contributing to prostate tumorigenesis. PMID: 24694733
    13. EGF signaling collaboratively regulates TGF-beta-induced TMEPAI expression. PMID: 25482449
    14. TMEPAI is translocated on the lysosome and late endosome, and that association with Nedd4 is required for the transport of TMEPAI to the lysosome. PMID: 24933703
    15. TMEPAI promotes tumorigenic activities in lung cancer cells. PMID: 24438557
    16. The levels of TMEPAI in lung tumor tissues are very high. PMID: 23615405
    17. Differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone. PMID: 17318295
    18. Results suggest that TMEPAI functions in breast cancer as a molecular switch that converts TGF-beta from a tumor suppressor to a tumor promoter. PMID: 20610632
    19. Expression of PMEPA1 was well maintained both in colon cancer primary tumors and in colon cancer liver metastases. PMID: 12670906
    20. PMEPA1 negatively regulates growth of androgen responsive or refractory prostate cancer cells, and these functions may be mediated through the interaction of PMEPA1 with the NEDD4 protein. PMID: 12907594
    21. DNA methylation within the PMEPA1 promoter downstream sequences suggests that methylation of SP1 binding sites may also contribute to the repression of PMEPA1 gene PMID: 18174752
    22. decreased PMEPA1 expression frequently noted in prostate cancers may lead to increased AR functions and strengthen the biological role of the NEDD4-binding protein PMEPA1 in prostate cancers PMID: 18703514

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
  • 蛋白家族:
    PMEPA1 family
  • 組織特異性:
    Highest expression in prostate. Also expressed in ovary.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 14107

    OMIM: 606564

    KEGG: hsa:56937

    STRING: 9606.ENSP00000345826

    UniGene: Hs.517155



主站蜘蛛池模板: 免费大片av手机看片不卡| 丰满多毛的大隂户视频| 天天做天天爱夜夜爽| 骚虎视频在线观看| 成人午夜亚洲精品无码区毛片| 国产日韩综合av在线观看一区 | 中文字幕人妻被公上司喝醉| 国产综合一区二区三区黄页秋霞| 性高朝久久久久久久| 在线看片人成视频免费无遮挡| 精品无码一区二区三区不卡| 一本大道在线观看无码一区| 无码三级在线看中文字幕完整版 | 无遮挡激情视频国产在线观看 | 国产人妻高清国产拍精品| 人妻中出无码一区二区三区| 99精品人妻少妇一区二区| 欧洲亚洲精品久久久久| 激情综合色综合久久综合| 制服视频在线一区二区| 野外性史欧美k8播放| 国产欧美一区二区三区免费视频| 精品少妇ay一区二区三区| 午夜片无码区在线观看视频| 亚洲国产丝袜精品一区| 色老板精品视频在线观看| 激情偷乱人成视频在线观看| 中文字幕av无码人妻| 久久久久久人妻精品一区| 青草草在线视频永久免费| 久久久久爽爽爽爽一区老女人| 超caopor在线公开视频| 性高湖久久久久久久久| 亚洲男同志网站| 无码国产一区二区三区四区| 成人无码亚洲精品无码| 亚洲日韩乱码久久久久久| 亚洲欧洲自拍拍偷精品 美利坚| 在线天堂资源www中文| 中文字幕乱码人妻综合二区三区| 国产精品99久久免费|