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  4. Recombinant Human Tensin-3 (TNS3), partial

Recombinant Human Tensin-3 (TNS3), partial

  • 中文名稱：
    人TNS3重組蛋白
  • 貨號：
    CSB-YP731561HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TNS3重組蛋白
  • 貨號：
    CSB-EP731561HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TNS3重組蛋白
  • 貨號：
    CSB-EP731561HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TNS3重組蛋白
  • 貨號：
    CSB-BP731561HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TNS3重組蛋白
  • 貨號：
    CSB-MP731561HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TNS3
  • Uniprot No.：
  • 別名：
    TEM 6; TEM6; TENS 1; TENS 3; TENS1; TENS3; TENS3_HUMAN; Tensin-3; tensin-like SH2 domain containing 1; Tensin-like SH2 domain containing protein 1; Tensin-like SH2 domain- containing protein 1; Tensin-like SH2 domain-containing protein 1; thyroid specific PTB domain protein; TNS 3; TNS3; TPP; Tumor endothelial marker 6
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development.
  • 基因功能參考文獻：
    1. Our work identifies Tns3 as a crucial focal adhesion component regulated by, and functionally contributing to, the switch between adhesive and non-adhesive states in MDA-MB-468 cancer cells. PMID: 28515231
    2. A phosphorylation-mediated molecular switch comprising DLC), TNS3, PTEN and PI3K controls the spatiotemporal activation of Rac1 and RhoA, thereby initiating directional cell migration induced by growth factors. PMID: 26166433
    3. The depletion of tensin-3 suppressed breast cancer cell invasiveness. PMID: 25814362
    4. The phenotypic changes observed in proband cells may arise from TNS3 haploinsufficiency, causing partial loss of full-length Tensin3 protein. Tensin3 plays a rol in cytoskeletal organisation and cell motility. PMID: 23809228
    5. These results reveal a differential methylation pattern in the TNS3 promoter occurring in human renal cell carcinoma. PMID: 23803643
    6. Tensin3 may function as a platform for the disassembly of EGF-related signaling complexes at focal adhesions. PMID: 15140944
    7. Data show that EGF downregulates tensin-3 expression, and concomitantly upregulates cten, a tensin family member that lacks the actin-binding domain. PMID: 17643115
    8. TNS3-EXOC6B and EXOC6B-TNS3 fusion transcripts are detected in a premature male newborn with a complex multisystemic phenotype associated with a balanced translocation. PMID: 18424204
    9. Tensin3 mRNA is expressed abundantly in all twelve functional adenomas at almost the same level as in normal thyroid tissue. PMID: 18561090
    10. Tensins may represent a novel group of metastasis suppressors in the kidney, the loss of which leads to greater tumor cell motility and consequent metastasis. PMID: 19194507

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  • 亞細胞定位：
    Cell junction, focal adhesion.
  • 組織特異性：
    Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial
  • 數據庫鏈接：

    HGNC: 21616

    OMIM: 606825

    KEGG: hsa:64759

    STRING: 9606.ENSP00000312143

    UniGene: Hs.520814



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