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  4. Recombinant Human TSC22 domain family protein 1 (TSC22D1), partial

Recombinant Human TSC22 domain family protein 1 (TSC22D1), partial

  • 中文名稱：
    人TSC22D1重組蛋白
  • 貨號：
    CSB-YP623011HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TSC22D1重組蛋白
  • 貨號：
    CSB-EP623011HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TSC22D1重組蛋白
  • 貨號：
    CSB-EP623011HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TSC22D1重組蛋白
  • 貨號：
    CSB-BP623011HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TSC22D1重組蛋白
  • 貨號：
    CSB-MP623011HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TSC22D1
  • Uniprot No.：
  • 別名：
    Cerebral protein 2; DKFZp686O19206; Hucep 2; Hucep2; KIAA1994; MGC17597; OTTHUMP00000040978; Ptg 2; Regulatory protein TSC 22; Regulatory protein TSC-22; Regulatory protein TSC22; RP11 269C23.2; T22D1_HUMAN; TGFB stimulated clone 22 homolog; TGFB-stimulated clone 22 homolog; TGFB1I4; TGFbeta stimulated clone 22; Transcriptional regulator TSC 22; Transforming growth factor beta 1 induced transcript 4; Transforming growth factor beta 1 induced transcript 4 protein; Transforming growth factor beta stimulated protein TSC 22; Transforming growth factor beta-1-induced transcript 4 protein; TSC 22; TSC22; TSC22 domain family 1 isoform 2; TSC22 domain family member 1; TSC22 domain family protein 1; TSC22D1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.
  • 基因功能參考文獻：
    1. TSC22 could suppress tumor by inhibiting cell proliferation in colorectal cancer cell lines. Multivariate Cox regression analysis confirmed TSC22 expression as independent predictors of the OS in CRC patients PMID: 29481799
    2. TSC-22 acts as a tumor suppressor by safeguarding p53 from poly-ubiquitination mediated-degradation. PMID: 22870275
    3. we report that induced Tsc-22 leads to enhancement of TGF-beta-dependent signaling and enhancement is blocked by expression of a dominant-negative Tsc-22 mutant PMID: 21881999
    4. Differential regulation of antagonistic TSC22D1 variants is required for the establishment of oncogene-induced cellular senescence. PMID: 21448135
    5. Results support role of TSC22D1 as an enhancer of CNP transcription and suggest that TGF-beta-induced upregulation of CNP expression in smooth muscle may be mediated in part by increased transcription of TSC22D1. PMID: 20802130
    6. Long form of TSC22DF is evolutionarily conserved and has growth-regulating potential. PMID: 20149264
    7. Leucine Zipper structure of TSC22 markedly inhibits the anchorage independent growth of salivary gland cancer cells PMID: 11836610
    8. TSC-22 is an important downstream component of PPARgamma and TGF-beta signaling during intestinal epithelial cell differentiation PMID: 12468551
    9. findings suggest that the TSC-22 gene (-396) A allele is associated with an increasing risk of diabetic nephropathy PMID: 12757981
    10. Upregulation of TSC-22 mRNA by TGF-beta 1 is achieved by mRNA stabilization. PMID: 12767908
    11. Tsc-22 modulates the TGF-beta-dependant signaling pathway and binds to and modulate the transcriptional activity of Smad3 and Smad4. It has effect on cellular differentiation PMID: 15881652
    12. expression of TSC-22 in prostate is restricted to basal layer; maybe useful marker for differentation between normal and malignant acinar epithelium of prostate PMID: 16106424
    13. TSC-22 is a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD PMID: 17690703
    14. Expression of TSC-22 was frequently observed in the tumor cells with differentiated-phenotypes, although rarely in the cells with growing potentials. PMID: 18288391
    15. interaction between fortilin and TSC-22 prevents apoptosis via the destabilization of TSC-22 in ovarian carcinoma cells PMID: 18325344

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    TSC-22/Dip/Bun family
  • 組織特異性：
    Widely expressed in fetal and adult tissues.
  • 數據庫鏈接：

    HGNC: 16826

    OMIM: 607715

    KEGG: hsa:8848

    STRING: 9606.ENSP00000397435

    UniGene: Hs.436383



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