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  4. Recombinant Human TERF1-interacting nuclear factor 2 (TINF2)

Recombinant Human TERF1-interacting nuclear factor 2 (TINF2)

  • 中文名稱：
    人TINF2重組蛋白
  • 貨號：
    CSB-YP874799HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TINF2重組蛋白
  • 貨號：
    CSB-EP874799HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TINF2重組蛋白
  • 貨號：
    CSB-EP874799HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TINF2重組蛋白
  • 貨號：
    CSB-BP874799HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TINF2重組蛋白
  • 貨號：
    CSB-MP874799HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TINF2
  • Uniprot No.：
  • 別名：
    AW552114; D14Wsu146e; DKCA3; MGC94711; TERF 1 (TRF 1) interacting nuclear factor 2; TERF 1 interacting nuclear factor 2; TERF1 (TRF1) interacting nuclear factor 2; TERF1 interacting nuclear factor 2; TERF1-interacting nuclear factor 2; Tin 2; TIN2; TINF 2; Tinf2; TINF2_HUMAN; TRF 1 interacting nuclear factor 2; TRF1 interacting nuclear factor 2; TRF1-interacting nuclear protein 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-451
  • 氨基酸序列
    ATPLVAGPA ALRFAAAASW QVVRGRCVEH FPRVLEFLRS LRAVAPGLVR YRHHERLCMG LKAKVVVELI LQGRPWAQVL KALNHHFPES GPIVRDPKAT KQDLRKILEA QETFYQQVKQ LSEAPVDLAS KLQELEQEYG EPFLAAMEKL LFEYLCQLEK ALPTPQAQQL QDVLSWMQPG VSITSSLAWR QYGVDMGWLL PECSVTDSVN LAEPMEQNPP QQQRLALHNP LPKAKPGTHL PQGPSSRTHP EPLAGRHFNL APLGRRRVQS QWASTRGGHK ERPTVMLFPF RNLGSPTQVI SKPESKEEHA IYTADLAMGT RAASTGKSKS PCQTLGGRAL KENPVDLPAT EQKENCLDCY MDPLRLSLLP PRARKPVCPP SLCSSVITIG DLVLDSDEEE NGQGEGKESL ENYQKTKFDT LIPTLCEYLP PSGHGAIPVS SCDCRDSSRP L
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
  • 基因功能參考文獻：
    1. The TIN2 plays an important role in maintaining the stable shelterin complex required for proper telomere end protection. PMID: 29160297
    2. We report ophthalmic findings in twins with Revesz syndrome due to a previously unreported mutation in TINF2 and propose that phenotypic and molecular overlaps between DKC spectrum disorders and pediatric retinal vasculopathies may reflect a shared pathophysiologic basis. PMID: 28095086
    3. demonstrate here the presence of a novel spliced isoform of TIN2 in chronic lymphocytic leukemia (CLL), related to deletion of exon 2 in the TIN2 gene PMID: 28575699
    4. data supports a mechanism whereby telomerase deficiency and subsequent shortened telomeres initiate a DNA damage response and create a pro-oxidant environment, especially in Dyskeratosis Congenita cells carrying TINF2 mutations PMID: 26859482
    5. telomerase elongates telomeres at a reduced frequency in TIN2-R282H heterozygous cells; this recruitment defect is further corroborated by examining the effect of this mutation on telomerase-telomere co-localization. PMID: 26230315
    6. Our findings identify TINF2 as a mutant telomere gene in familial pulmonary fibrosis and suggest that infertility may precede the presentation of pulmonary fibrosis in a small subset of adults with telomere syndromes PMID: 25539146
    7. A potential mitotic regulation of TIN2 by phosphorylation, is reported. PMID: 23977114
    8. results suggest a link between telomeric proteins (TIN2)and metabolic control, providing an additional mechanism by which telomeric proteins regulate cancer and aging PMID: 22885005
    9. Results suggests that the disruption of TIN2-TRF1 interaction may contribute to the severe dyskeratosis congenita phenotype observed in the context of the TIN2 truncation mutation. PMID: 21477109
    10. The positive correlation between telomere length in dyskeratosis congenital and percent of LINE-1 methylation was restricted to TINF2 mutations. PMID: 21981348
    11. Frameshift or nonsense mutations in TIN2 gene having very short telomeres are found in patients with dyskeratosis congenita. PMID: 21199492
    12. Siah2 acts as an E3 ligase to directly ubiquitylate TIN2 in vitro. PMID: 22064479
    13. These results demonstrate the important roles that Sp1 and NF-kappaB play in regulating the expression of the human telomere-binding protein TIN2. PMID: 21731707
    14. The presence of dysfunctional telomeres in chronic lymphocytic leukemia did not correlate with telomere shortening or chromatin marks deregulation but with a down-regulation of 2 shelterin genes: ACD and TINF2. PMID: 21355086
    15. TIN2 mutations in DC may compromise the telomere recruitment of telomerase, leading to telomere shortening and the associated pathogenesis. PMID: 21536674
    16. exon 6 of TINF2 natural mutations in 2/142 Japanese patients with acquired acquired bone marrow failure syndromes PMID: 20560964
    17. TINF2 mutation of shelterin complex is associated with dyskeratosis congenita. PMID: 20979174
    18. The expression of TINF2 may work to reduce the telomere length in precancerous lesions and offer new insight into the mechanism of carcinogenesis in gastric cancer. PMID: 20127252
    19. TIN2-anchored TPP1 plays a major role in the recruitment of telomerase to telomeres in human cells. PMID: 20404094
    20. Co-localises with the interstitial TTAGGG repeats in interstitial telomeres. PMID: 11938440
    21. Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers. PMID: 12530079
    22. TIN2 alters the conformation of TRF1, which favours a tertiary telomeric structure that hinders telomerase from gaining access to telomeres PMID: 12835755
    23. Partial knockdown of TIN2 by small hairpin RNA in a telomerase-positive cell line resulted in telomere elongation, which is typical of reduced TRF1 function. PMID: 15133513
    24. TIN2 mutants defective in binding of TRF1 or TRF2 induce a DNA damage response and destabilize TRF1 and TRF2 at telomeres in human cells. PMID: 15292264
    25. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres PMID: 15316005
    26. May be involved in multistep hepatocarcinogenesis by playing crucial role in telomere shortening. PMID: 15632001
    27. a novel extra-telomeric organization of TIN2 is associated with the control of cell proliferation; TIN2 is an important regulator of mammary epithelial differentiation PMID: 15741234
    28. coordinated interactions among TPP1, TIN2, TRF1, and TRF2 may ensure robust assembly of the telosome, telomere targeting of its subunits, and, ultimately, regulated telomere maintenance PMID: 16880378
    29. TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. PMID: 18252230
    30. Results suggest that distinct TIN2 complexes exist and that TIN2-15C-sensitive subcomplexes are particularly important for cell survival in the absence of functional p53. PMID: 18443218
    31. In a large series, TINF2 mutations account for approximately 11% of all patients with dyskeratosis congenita. PMID: 18669893
    32. conclude that a significant proportion of patients who underwent unrelated donor hematopoietic stem cell transplantation for severe aplastic anemia harbored mutations in TINF2 and may have had occult dyskeratosis congenita PMID: 19090550
    33. Our results suggest a dual role for TIN2 in mediating the function of the shelterin complex and tethering telomeres to the nuclear matrix. PMID: 19229133

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  • 相關疾病：
    Dyskeratosis congenita, autosomal dominant, 3 (DKCA3); Dyskeratosis congenita, autosomal dominant, 5 (DKCA5)
  • 亞細胞定位：
    Nucleus. Chromosome, telomere. Note=Associated with telomeres.; [Isoform 1]: Nucleus matrix.
  • 組織特異性：
    Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 11824

    OMIM: 268130

    KEGG: hsa:26277

    STRING: 9606.ENSP00000267415

    UniGene: Hs.496191



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