在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TINF2 Antibody

  • 中文名稱:
    TINF2兔多克隆抗體
  • 貨號:
    CSB-PA874799LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA874799LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TINF2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TINF2
  • 別名:
    AW552114 antibody; D14Wsu146e antibody; DKCA3 antibody; MGC94711 antibody; TERF 1 (TRF 1) interacting nuclear factor 2 antibody; TERF 1 interacting nuclear factor 2 antibody; TERF1 (TRF1) interacting nuclear factor 2 antibody; TERF1 interacting nuclear factor 2 antibody; TERF1-interacting nuclear factor 2 antibody; Tin 2 antibody; TIN2 antibody; TINF 2 antibody; Tinf2 antibody; TINF2_HUMAN antibody; TRF 1 interacting nuclear factor 2 antibody; TRF1 interacting nuclear factor 2 antibody; TRF1-interacting nuclear protein 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human TERF1-interacting nuclear factor 2 protein (210-451AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,TINF2 Antibody (CSB-PA874799LA01HU),的標記方式是Non-conjugated。對于TINF2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA874799LB01HU TINF2 Antibody, HRP conjugated ELISA
    FITC CSB-PA874799LC01HU TINF2 Antibody, FITC conjugated
    Biotin CSB-PA874799LD01HU TINF2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
  • 基因功能參考文獻:
    1. The TIN2 plays an important role in maintaining the stable shelterin complex required for proper telomere end protection. PMID: 29160297
    2. We report ophthalmic findings in twins with Revesz syndrome due to a previously unreported mutation in TINF2 and propose that phenotypic and molecular overlaps between DKC spectrum disorders and pediatric retinal vasculopathies may reflect a shared pathophysiologic basis. PMID: 28095086
    3. demonstrate here the presence of a novel spliced isoform of TIN2 in chronic lymphocytic leukemia (CLL), related to deletion of exon 2 in the TIN2 gene PMID: 28575699
    4. data supports a mechanism whereby telomerase deficiency and subsequent shortened telomeres initiate a DNA damage response and create a pro-oxidant environment, especially in Dyskeratosis Congenita cells carrying TINF2 mutations PMID: 26859482
    5. telomerase elongates telomeres at a reduced frequency in TIN2-R282H heterozygous cells; this recruitment defect is further corroborated by examining the effect of this mutation on telomerase-telomere co-localization. PMID: 26230315
    6. Our findings identify TINF2 as a mutant telomere gene in familial pulmonary fibrosis and suggest that infertility may precede the presentation of pulmonary fibrosis in a small subset of adults with telomere syndromes PMID: 25539146
    7. A potential mitotic regulation of TIN2 by phosphorylation, is reported. PMID: 23977114
    8. results suggest a link between telomeric proteins (TIN2)and metabolic control, providing an additional mechanism by which telomeric proteins regulate cancer and aging PMID: 22885005
    9. Results suggests that the disruption of TIN2-TRF1 interaction may contribute to the severe dyskeratosis congenita phenotype observed in the context of the TIN2 truncation mutation. PMID: 21477109
    10. The positive correlation between telomere length in dyskeratosis congenital and percent of LINE-1 methylation was restricted to TINF2 mutations. PMID: 21981348
    11. Frameshift or nonsense mutations in TIN2 gene having very short telomeres are found in patients with dyskeratosis congenita. PMID: 21199492
    12. Siah2 acts as an E3 ligase to directly ubiquitylate TIN2 in vitro. PMID: 22064479
    13. These results demonstrate the important roles that Sp1 and NF-kappaB play in regulating the expression of the human telomere-binding protein TIN2. PMID: 21731707
    14. The presence of dysfunctional telomeres in chronic lymphocytic leukemia did not correlate with telomere shortening or chromatin marks deregulation but with a down-regulation of 2 shelterin genes: ACD and TINF2. PMID: 21355086
    15. TIN2 mutations in DC may compromise the telomere recruitment of telomerase, leading to telomere shortening and the associated pathogenesis. PMID: 21536674
    16. exon 6 of TINF2 natural mutations in 2/142 Japanese patients with acquired acquired bone marrow failure syndromes PMID: 20560964
    17. TINF2 mutation of shelterin complex is associated with dyskeratosis congenita. PMID: 20979174
    18. The expression of TINF2 may work to reduce the telomere length in precancerous lesions and offer new insight into the mechanism of carcinogenesis in gastric cancer. PMID: 20127252
    19. TIN2-anchored TPP1 plays a major role in the recruitment of telomerase to telomeres in human cells. PMID: 20404094
    20. Co-localises with the interstitial TTAGGG repeats in interstitial telomeres. PMID: 11938440
    21. Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers. PMID: 12530079
    22. TIN2 alters the conformation of TRF1, which favours a tertiary telomeric structure that hinders telomerase from gaining access to telomeres PMID: 12835755
    23. Partial knockdown of TIN2 by small hairpin RNA in a telomerase-positive cell line resulted in telomere elongation, which is typical of reduced TRF1 function. PMID: 15133513
    24. TIN2 mutants defective in binding of TRF1 or TRF2 induce a DNA damage response and destabilize TRF1 and TRF2 at telomeres in human cells. PMID: 15292264
    25. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres PMID: 15316005
    26. May be involved in multistep hepatocarcinogenesis by playing crucial role in telomere shortening. PMID: 15632001
    27. a novel extra-telomeric organization of TIN2 is associated with the control of cell proliferation; TIN2 is an important regulator of mammary epithelial differentiation PMID: 15741234
    28. coordinated interactions among TPP1, TIN2, TRF1, and TRF2 may ensure robust assembly of the telosome, telomere targeting of its subunits, and, ultimately, regulated telomere maintenance PMID: 16880378
    29. TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. PMID: 18252230
    30. Results suggest that distinct TIN2 complexes exist and that TIN2-15C-sensitive subcomplexes are particularly important for cell survival in the absence of functional p53. PMID: 18443218
    31. In a large series, TINF2 mutations account for approximately 11% of all patients with dyskeratosis congenita. PMID: 18669893
    32. conclude that a significant proportion of patients who underwent unrelated donor hematopoietic stem cell transplantation for severe aplastic anemia harbored mutations in TINF2 and may have had occult dyskeratosis congenita PMID: 19090550
    33. Our results suggest a dual role for TIN2 in mediating the function of the shelterin complex and tethering telomeres to the nuclear matrix. PMID: 19229133

    顯示更多

    收起更多

  • 相關疾病:
    Dyskeratosis congenita, autosomal dominant, 3 (DKCA3); Dyskeratosis congenita, autosomal dominant, 5 (DKCA5)
  • 亞細胞定位:
    Nucleus. Chromosome, telomere. Note=Associated with telomeres.; [Isoform 1]: Nucleus matrix.
  • 組織特異性:
    Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接:

    HGNC: 11824

    OMIM: 268130

    KEGG: hsa:26277

    STRING: 9606.ENSP00000267415

    UniGene: Hs.496191



主站蜘蛛池模板: 精品国产成人网站一区在线| 亚洲成av人片在线观看www| 麻豆精品一区二区综合av| 亚洲成a人片在线观看高清| 国产97超碰人人做人人爱| 精品国产麻豆免费人成网站| 国产精品视频一区二区亚瑟| 久久狼人大香伊蕉国产| 亚洲国产美女精品久久久久| 日本少妇毛茸茸高潮| 日本丰满白嫩大屁股ass| 猫咪www免费人成网站无码| 国产婷婷亚洲999精品小说 | 亚洲国产成人精品青青草原| 一二三四视频在线观看日本| 亚洲爆乳aaa无码专区| 中文字幕亚洲综合久久菠萝蜜| 成在人线av无码免费| 亚洲www啪成人一区二区| 久久性色欲av免费精品观看| 亚洲第一在线综合网站| 久久这里精品国产99丫e6| 久久久无码精品亚洲日韩蜜桃| 中文字幕人妻无码专区| 亚洲性线免费观看视频成熟 | 激情久久亚洲小说| 国产高清在线精品一区二区三区| 国产欧美一区二区精品久久久| 欧美成人看片一区二区三区尤物 | 国产成av人片久青草影院| 草的我好爽视频| 大肉大捧一进一出好爽mba| 插鸡网站在线播放免费观看| 2019亚洲午夜无码天堂| 色偷偷色噜噜狠狠网站年轻人| 精品国精品国产自在久国产应用| 国产99久久九九精品无码| 欧美熟妇性xxxx交潮喷| 最新亚洲人成无码网站| 欧美日韩欧美| 欧美性色大片在线观看|