在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Store-operated calcium entry-associated regulatory factor (SARAF), partial

  • 中文名稱:
    人SARAF重組蛋白
  • 貨號:
    CSB-EP853392HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    SARAF
  • Uniprot No.:
  • 別名:
    FLJ22274; FOAP 7; HBV X transactivated gene 3 protein; HBV X-transactivated gene 3 protein; HBV XAg-transactivated protein 3; HSPC035; MGC8721; Protein FOAP 7; Protein FOAP-7; TMEM 66; Tmem66; TMM66_HUMAN; Transmembrane protein 66; XTP3
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Cytoplasmic Domain
  • 來源:
    E.coli
  • 分子量:
    31.5kDa
  • 表達區域:
    195-339aa
  • 氨基酸序列
    SDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSGSYSVCSNSDTKTRTASGYGGTRRR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
  • 基因功能參考文獻:
    1. SARAF also interacts with Orai1 and TRPC1 in cells endogenously expressing STIM1 and cells with a low STIM1 expression and modulates channel function. This review focuses on the modulation by SARAF of SOCE and other forms of Ca(2+) influx mediated by Orai1 and TRPC1 in order to provide spatio-temporally regulated Ca(2+) signals. PMID: 29223474
    2. This activation was sensitive to Src kinase inhibition, but not to CAMKII nor PKC inhibition, a result that sets STIM1 and SOCE as downstream targets of the axis Src-Raf-MEK-ERK, rather than upstream regulators. PMID: 28866365
    3. These findings suggest that the surface location of SARAF is dependent on the expression of STIM1 in the plasma membrane. PMID: 27414851
    4. SARAF modulates TRPC1, but not TRPC6, channel function in a STIM1-independent manner PMID: 27506849
    5. SARAF overexpression attenuated store operated Ca2+ entry and the STIM1-Orai1 interaction in cells endogenously expressing STIM1 and Orai1 while RNAi-mediated SARAF silencing induced opposite effects. PMID: 27068144
    6. SARAF is constitutively expressed in the plasma membrane and interacts with Orai1. PMID: 26817842
    7. Deletion of STIM1(448-490) and, in particular, STIM1(447-460) and STIM1(475-490) markedly enhances interaction of SARAF with STIM1. PMID: 23816623
    8. Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients. PMID: 23049731
    9. Study shows that SARAF is an endoplasmic reticulum resident protein, which responds to cytosolic Ca2+ elevation after ER Ca2+ refilling by promoting a slow inactivation process of STIM2-dependent basal SOCE activity, as well as STIM1-mediated SOCE activity. PMID: 22464749

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    SARAF family
  • 組織特異性:
    Highly expressed in macrophages.
  • 數據庫鏈接:

    HGNC: 28789

    OMIM: 614768

    KEGG: hsa:51669

    STRING: 9606.ENSP00000256255

    UniGene: Hs.521487



主站蜘蛛池模板: 天天综合网网欲色| 国产精品一区二区 尿失禁| 色偷偷人人澡人人爽人人模| 性久久久久久| 国产成人 综合 亚洲欧洲| 综合欧美日韩国产成人| 无尺码精品产品网站| 久久久久久久久久久国产| 天堂在线资源中文在线8| 开心色怡人综合网站| 东北老女人高潮大叫对白| 国产成a人亚洲精品无码樱花| 狠狠色成人一区二区三区| 久久久久国产精品人妻电影| 好男人社区在线www| 无码一区二区三区免费| 久久性色欲av免费精品观看| 99国产欧美另娄久久久精品| 怡红院a∨人人爰人人爽| 亚洲色大成网站www永久一区| 午夜成人亚洲理论片在线观看 | 亚洲熟妇无码av不卡在线观看| 国产乱码二卡3卡四卡| 国产女人高潮叫床视频| 婷婷五月综合激情中文字幕| 97久久国产成人免费网站| 999久久久国产精品| 少妇愉情理伦片高潮日本| 国产欧美另类精品久久久| 久久大香国产成人av| 风韵丰满熟妇啪啪区老老熟妇| 极品人妻被黑人中出种子| 春色校园亚洲愉拍自拍| 久本草在线中文字幕亚洲| 日韩 欧美 国产 一区三| 亚洲熟妇无码八v在线播放| 国产男女猛烈无遮挡免费视频| 国产精品亚洲一区二区三区喷水| 欧美一性一乱一交一免费视频 | 高中生自慰www网站| 精产国品一区二区三产区|