在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SARAF Antibody

  • 中文名稱:
    SARAF兔多克隆抗體
  • 貨號(hào):
    CSB-PA853392HA01HU
  • 規(guī)格:
    ¥440
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SARAF Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SARAF
  • 別名:
    FLJ22274 antibody; FOAP 7 antibody; HBV X transactivated gene 3 protein antibody; HBV X-transactivated gene 3 protein antibody; HBV XAg-transactivated protein 3 antibody; HSPC035 antibody; MGC8721 antibody; Protein FOAP 7 antibody; Protein FOAP-7 antibody; TMEM 66 antibody; Tmem66 antibody; TMM66_HUMAN antibody; Transmembrane protein 66 antibody; XTP3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Store-operated calcium entry-associated regulatory factor protein (195-339AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁(yè)面中的產(chǎn)品,SARAF Antibody (CSB-PA853392HA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于SARAF Antibody,我們還提供其他標(biāo)記。見(jiàn)下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA853392HB01HU SARAF Antibody, HRP conjugated ELISA
    FITC CSB-PA853392HC01HU SARAF Antibody, FITC conjugated
    Biotin CSB-PA853392HD01HU SARAF Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
  • 基因功能參考文獻(xiàn):
    1. SARAF also interacts with Orai1 and TRPC1 in cells endogenously expressing STIM1 and cells with a low STIM1 expression and modulates channel function. This review focuses on the modulation by SARAF of SOCE and other forms of Ca(2+) influx mediated by Orai1 and TRPC1 in order to provide spatio-temporally regulated Ca(2+) signals. PMID: 29223474
    2. This activation was sensitive to Src kinase inhibition, but not to CAMKII nor PKC inhibition, a result that sets STIM1 and SOCE as downstream targets of the axis Src-Raf-MEK-ERK, rather than upstream regulators. PMID: 28866365
    3. These findings suggest that the surface location of SARAF is dependent on the expression of STIM1 in the plasma membrane. PMID: 27414851
    4. SARAF modulates TRPC1, but not TRPC6, channel function in a STIM1-independent manner PMID: 27506849
    5. SARAF overexpression attenuated store operated Ca2+ entry and the STIM1-Orai1 interaction in cells endogenously expressing STIM1 and Orai1 while RNAi-mediated SARAF silencing induced opposite effects. PMID: 27068144
    6. SARAF is constitutively expressed in the plasma membrane and interacts with Orai1. PMID: 26817842
    7. Deletion of STIM1(448-490) and, in particular, STIM1(447-460) and STIM1(475-490) markedly enhances interaction of SARAF with STIM1. PMID: 23816623
    8. Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients. PMID: 23049731
    9. Study shows that SARAF is an endoplasmic reticulum resident protein, which responds to cytosolic Ca2+ elevation after ER Ca2+ refilling by promoting a slow inactivation process of STIM2-dependent basal SOCE activity, as well as STIM1-mediated SOCE activity. PMID: 22464749

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    SARAF family
  • 組織特異性:
    Highly expressed in macrophages.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 28789

    OMIM: 614768

    KEGG: hsa:51669

    STRING: 9606.ENSP00000256255

    UniGene: Hs.521487



主站蜘蛛池模板: 亚洲开心婷婷中文字幕| 狠狠色噜噜狠狠色综合久| 新区乱码无人区二精东| 欧美精品18videos性欧美| 曰韩无码二三区中文字幕| 久久电影网午夜鲁丝片免费| 大学生久久香蕉国产线看观看| 蜜臀av色欲a片无码一区| 中文字幕亚洲一区二区三区| 国产欠欠欠18一区二区| 色偷拍 自怕 亚洲 10p| 真实国产精品视频400部| 中文字幕无码精品亚洲资源网久久| 亚洲欧洲日产国码无码av一| 国产黑色丝袜在线观看下| 麻豆专媒体一区二区| 国产偷国产偷亚洲清高app| 久久无码人妻精品一区二区三区| 风韵犹存丰满大屁股熟妇| 色综合a怡红院怡红院| 国语自产精品视频在线看| 俺也来俺也去俺也射| 亚洲精品久久一区二区三区四区| 人妻aⅴ中文字幕无码| 亚洲精品日本久久一区二区三区| 欧美人与动欧交视频| 国产精品乱子伦xxxx| 浓毛欧美老妇乱子伦视频| 免费的黄网站在线观看| 亚洲精品无码久久千人斩| 在线观看国产精品va| 少妇高潮av久久久久久| 狠狠色丁香久久婷婷综合图片 | 全球av集中精品导航福利| 国产69囗曝吞精在线视频| 波多野结衣超清无码专区| 精品久久香蕉国产线看观看亚洲| 欧美精品18videosex性欧美| 人妻少妇精品无码专区芭乐视网 | 国产69精品久久久久孕妇| 曰本无码人妻丰满熟妇啪啪|