在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SARAF Antibody

SARAF Antibody

  • 中文名稱：
    SARAF兔多克隆抗體
  • 貨號(hào)：
    CSB-PA853392HA01HU
  • 規(guī)格：
    ￥440
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SARAF Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SARAF
  • 別名：
    FLJ22274 antibody; FOAP 7 antibody; HBV X transactivated gene 3 protein antibody; HBV X-transactivated gene 3 protein antibody; HBV XAg-transactivated protein 3 antibody; HSPC035 antibody; MGC8721 antibody; Protein FOAP 7 antibody; Protein FOAP-7 antibody; TMEM 66 antibody; Tmem66 antibody; TMM66_HUMAN antibody; Transmembrane protein 66 antibody; XTP3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Store-operated calcium entry-associated regulatory factor protein (195-339AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，SARAF Antibody (CSB-PA853392HA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于SARAF Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA853392HB01HU SARAF Antibody, HRP conjugated ELISA
    FITC CSB-PA853392HC01HU SARAF Antibody, FITC conjugated
    Biotin CSB-PA853392HD01HU SARAF Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
  • 基因功能參考文獻(xiàn)：
    1. SARAF also interacts with Orai1 and TRPC1 in cells endogenously expressing STIM1 and cells with a low STIM1 expression and modulates channel function. This review focuses on the modulation by SARAF of SOCE and other forms of Ca(2+) influx mediated by Orai1 and TRPC1 in order to provide spatio-temporally regulated Ca(2+) signals. PMID: 29223474
    2. This activation was sensitive to Src kinase inhibition, but not to CAMKII nor PKC inhibition, a result that sets STIM1 and SOCE as downstream targets of the axis Src-Raf-MEK-ERK, rather than upstream regulators. PMID: 28866365
    3. These findings suggest that the surface location of SARAF is dependent on the expression of STIM1 in the plasma membrane. PMID: 27414851
    4. SARAF modulates TRPC1, but not TRPC6, channel function in a STIM1-independent manner PMID: 27506849
    5. SARAF overexpression attenuated store operated Ca2+ entry and the STIM1-Orai1 interaction in cells endogenously expressing STIM1 and Orai1 while RNAi-mediated SARAF silencing induced opposite effects. PMID: 27068144
    6. SARAF is constitutively expressed in the plasma membrane and interacts with Orai1. PMID: 26817842
    7. Deletion of STIM1(448-490) and, in particular, STIM1(447-460) and STIM1(475-490) markedly enhances interaction of SARAF with STIM1. PMID: 23816623
    8. Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients. PMID: 23049731
    9. Study shows that SARAF is an endoplasmic reticulum resident protein, which responds to cytosolic Ca2+ elevation after ER Ca2+ refilling by promoting a slow inactivation process of STIM2-dependent basal SOCE activity, as well as STIM1-mediated SOCE activity. PMID: 22464749

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    SARAF family
  • 組織特異性：
    Highly expressed in macrophages.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 28789

    OMIM: 614768

    KEGG: hsa:51669

    STRING: 9606.ENSP00000256255

    UniGene: Hs.521487



主站蜘蛛池模板： 色欲av永久无码精品无码蜜桃| 精选国产av精选一区二区三区| 无码毛片aaa在线| 人妻中文字幕av无码专区| 交换交换乱杂烩系列yy| 无码av片在线观看免费| 中国熟妇人妻xxxxx| 日本乱人伦在线观看| 国内揄拍国内精品对白86| 欧美黑人性暴力猛交喷水| 国产成年无码久久久久毛片| 亚洲欧美一区二区成人片 | 女人被狂c到高潮视频网站| 亚洲国产成人久久精品99| 在线看亚洲十八禁网站| 成人国产欧美大片一区| 久久久774这里只有精品17| 亚洲精品色情app在线下载观看| 国产亚洲精品久久久久婷婷瑜伽| 免费国产a国产片高清网站| 亚洲图片校园另激情类小说| 曰韩无码二三区中文字幕| 亚洲国产精品久久久久爰色欲| 少妇饥渴偷公乱av在线观看涩爱 | 最新中文字幕av无码专区| 真实国产乱子伦视频| 精品无码成人久久久久久| 欧美性猛交aaaa片黑人| 波多野结衣av一区二区全免费观看| 55夜色66夜色国产精品视频| 国产精品免费看久久久无码| 久久婷婷色综合一区二区| 亚洲欧美精品综合在线观看| 中日产幕无线码一区| 亚洲综合一区二区三区无码| 在线亚洲欧美日韩精品专区| 久久亚洲色www成人不卡| 久久国产精品波多野结衣av| 久章草国语自产拍在线观看| 久久亚洲欧美国产精品| 亚洲综合另类小说色区一|