在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SARAF Antibody, Biotin conjugated

  • 中文名稱:
    SARAF兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA853392HD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SARAF Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SARAF
  • 別名:
    FLJ22274 antibody; FOAP 7 antibody; HBV X transactivated gene 3 protein antibody; HBV X-transactivated gene 3 protein antibody; HBV XAg-transactivated protein 3 antibody; HSPC035 antibody; MGC8721 antibody; Protein FOAP 7 antibody; Protein FOAP-7 antibody; TMEM 66 antibody; Tmem66 antibody; TMM66_HUMAN antibody; Transmembrane protein 66 antibody; XTP3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Store-operated calcium entry-associated regulatory factor protein (195-339AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
  • 基因功能參考文獻:
    1. SARAF also interacts with Orai1 and TRPC1 in cells endogenously expressing STIM1 and cells with a low STIM1 expression and modulates channel function. This review focuses on the modulation by SARAF of SOCE and other forms of Ca(2+) influx mediated by Orai1 and TRPC1 in order to provide spatio-temporally regulated Ca(2+) signals. PMID: 29223474
    2. This activation was sensitive to Src kinase inhibition, but not to CAMKII nor PKC inhibition, a result that sets STIM1 and SOCE as downstream targets of the axis Src-Raf-MEK-ERK, rather than upstream regulators. PMID: 28866365
    3. These findings suggest that the surface location of SARAF is dependent on the expression of STIM1 in the plasma membrane. PMID: 27414851
    4. SARAF modulates TRPC1, but not TRPC6, channel function in a STIM1-independent manner PMID: 27506849
    5. SARAF overexpression attenuated store operated Ca2+ entry and the STIM1-Orai1 interaction in cells endogenously expressing STIM1 and Orai1 while RNAi-mediated SARAF silencing induced opposite effects. PMID: 27068144
    6. SARAF is constitutively expressed in the plasma membrane and interacts with Orai1. PMID: 26817842
    7. Deletion of STIM1(448-490) and, in particular, STIM1(447-460) and STIM1(475-490) markedly enhances interaction of SARAF with STIM1. PMID: 23816623
    8. Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients. PMID: 23049731
    9. Study shows that SARAF is an endoplasmic reticulum resident protein, which responds to cytosolic Ca2+ elevation after ER Ca2+ refilling by promoting a slow inactivation process of STIM2-dependent basal SOCE activity, as well as STIM1-mediated SOCE activity. PMID: 22464749

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    SARAF family
  • 組織特異性:
    Highly expressed in macrophages.
  • 數據庫鏈接:

    HGNC: 28789

    OMIM: 614768

    KEGG: hsa:51669

    STRING: 9606.ENSP00000256255

    UniGene: Hs.521487



主站蜘蛛池模板: 国产gv在线观看受被做哭| 99精品热这里只有精品| 国产亚洲精品第一综合另类灬| 亚洲欧洲免费三级网站| 国产精品人成视频免费国产| 亚洲午夜精品a片一区二区app| 夜夜香夜夜摸夜夜添视频| 宅女午夜福利免费视频| 欧美刺激性大交| 久久久www成人免费精品| 日本午夜精品一区二区三区电影 | 女人摸下面自熨视频在线播放 | 色一情一乱一伦一视频免费看| 国模小婕私拍鲜嫩玉门| 亚洲综合最新无码2020av| 久久―日本道色综合久久| 四虎精品成人a在线观看| 波多野结衣乳巨码无在线观看| 和岳每晚弄的高潮嗷嗷叫视频 | 高潮毛片无遮挡高清免费| аⅴ天堂中文在线网官网| 欧洲美洲精品一区二区三区| 日韩精品一区二区大桥未久| 国产精品嫩草影院入口一二三| 中国亚洲女人69内射少妇| 日日鲁鲁鲁夜夜爽爽狠狠| 天堂最新版资源网| 一本大道大臿蕉视频无码| 国产成人无码a区视频在线观看| 内射中出日韩无国产剧情| 污18禁污色黄网站免费| 九九99久久精品在免费线18| 99在线精品视频观看免费| 免费毛片全部不收费的| 欧美又粗又大又硬又长又爽视频| 国产福利无码一区在线| 无码丰满少妇2在线观看| 国产精品久久久久9999小说| 亚洲日产av中文字幕无码偷拍| 真人啪啪高潮喷水呻吟无遮挡| 三上悠亚ssⅰn939无码播放 |