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  4. Recombinant Human StAR-related lipid transfer protein 13 (STARD13), partial

Recombinant Human StAR-related lipid transfer protein 13 (STARD13), partial

  • 中文名稱：
    人STARD13重組蛋白
  • 貨號：
    CSB-YP896714HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人STARD13重組蛋白
  • 貨號：
    CSB-EP896714HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人STARD13重組蛋白
  • 貨號：
    CSB-EP896714HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人STARD13重組蛋白
  • 貨號：
    CSB-BP896714HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人STARD13重組蛋白
  • 貨號：
    CSB-MP896714HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    STARD13
  • Uniprot No.：
  • 別名：
    46H23.2; ARHGAP37; Deleted in liver cancer 2 protein; Deleted in liver cancer protein 2; DLC-2; DLC2; GT650; Rho GTPase activating protein on chromosome 13q12; Rho GTPase-activating protein; STA13; STA13_HUMAN; StAR related lipid transfer (START) domain containing 13; StAR-related lipid transfer protein 13; StARD13; START domain-containing protein 13
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.
  • 基因功能參考文獻：
    1. Study elucidated StarD13 messenger RNA as a Competitive endogenous messenger RNA (ceRNA) in regulating migration and invasion of breast cancer cells. MicroRNA-125b was identified to induce metastasis of MCF-7 cells and bind with both StarD13 3'UTR and TP53INP1 3'UTR. Therefore, a ceRNA interaction between StarD13 and TP53INP1 mediated by competitively binding to miR-125b was indicated. PMID: 29146309
    2. Low STARD13 expression is associated with metastasis of breast cancer. PMID: 26985770
    3. miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer. PMID: 27220320
    4. The tumor suppressor DLC2 and Kif1B are central components of a signaling network that guides spindle positioning, cell-cell adhesion and mitotic fidelity. PMID: 25518808
    5. Dimerization of DLC2 was required for its interaction with GKAP, which, in turn, potentiated GKAP self-association. PMID: 24938595
    6. Study describes STARD13 as a tumor suppressor playing a positive role in cancer motility. PMID: 24627003
    7. The present study further describes the role of StarD13 as a tumor suppressor as well as a Rho GAP. PMID: 24253896
    8. Importance of the regulation of RhoA activity in focal adhesions of astrocytoma cells and StarD13 is a GAP playing a major role in this process. PMID: 24333506
    9. In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13. [review] PMID: 23316797
    10. RhoGAP protein Stard13 is an essential regulator of pancreas tissue architecture in the mammalian embryo; Stard13 acts by regulating Rho signalling spatially and temporally during pancreas development. PMID: 23175628
    11. Authors detected an increase in p-ERK in StarD13 knockdown cells, uncovering a potential link between Rho GTPases and ERK activation. PMID: 22614672
    12. role of miR-125b in pro-metastasis by targeting STARD13 PMID: 22693547
    13. DLC2 inhibits the activity of Raf-1-ERK1/2-p70S6K via its RhoGAP function, resulting in the suppression of cell growth. PMID: 20629949
    14. has GAP activity specific for RhoA and Cdc42; inhibits the Rho mediated assembly of actin stress fibers in cultured cells and is underexpressed in hepatocellular carcinoma tissues PMID: 12531887
    15. underexpression is associated with poor prognosis in patients with hepatocellular carcinoma PMID: 18651974

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  • 亞細胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
  • 組織特異性：
    Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.
  • 數據庫鏈接：

    HGNC: 19164

    OMIM: 609866

    KEGG: hsa:90627

    STRING: 9606.ENSP00000338785

    UniGene: Hs.156551



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