在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

STARD13 Antibody

  • 中文名稱:
    STARD13兔多克隆抗體
  • 貨號:
    CSB-PA070215
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    STARD13
  • 別名:
    46H23.2 antibody; ARHGAP37 antibody; Deleted in liver cancer 2 protein antibody; Deleted in liver cancer protein 2 antibody; DLC-2 antibody; DLC2 antibody; GT650 antibody; Rho GTPase activating protein on chromosome 13q12 antibody; Rho GTPase-activating protein antibody; STA13 antibody; STA13_HUMAN antibody; StAR related lipid transfer (START) domain containing 13 antibody; StAR-related lipid transfer protein 13 antibody; StARD13 antibody; START domain-containing protein 13 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human StARD13.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.
  • 基因功能參考文獻:
    1. Study elucidated StarD13 messenger RNA as a Competitive endogenous messenger RNA (ceRNA) in regulating migration and invasion of breast cancer cells. MicroRNA-125b was identified to induce metastasis of MCF-7 cells and bind with both StarD13 3'UTR and TP53INP1 3'UTR. Therefore, a ceRNA interaction between StarD13 and TP53INP1 mediated by competitively binding to miR-125b was indicated. PMID: 29146309
    2. Low STARD13 expression is associated with metastasis of breast cancer. PMID: 26985770
    3. miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer. PMID: 27220320
    4. The tumor suppressor DLC2 and Kif1B are central components of a signaling network that guides spindle positioning, cell-cell adhesion and mitotic fidelity. PMID: 25518808
    5. Dimerization of DLC2 was required for its interaction with GKAP, which, in turn, potentiated GKAP self-association. PMID: 24938595
    6. Study describes STARD13 as a tumor suppressor playing a positive role in cancer motility. PMID: 24627003
    7. The present study further describes the role of StarD13 as a tumor suppressor as well as a Rho GAP. PMID: 24253896
    8. Importance of the regulation of RhoA activity in focal adhesions of astrocytoma cells and StarD13 is a GAP playing a major role in this process. PMID: 24333506
    9. In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13. [review] PMID: 23316797
    10. RhoGAP protein Stard13 is an essential regulator of pancreas tissue architecture in the mammalian embryo; Stard13 acts by regulating Rho signalling spatially and temporally during pancreas development. PMID: 23175628
    11. Authors detected an increase in p-ERK in StarD13 knockdown cells, uncovering a potential link between Rho GTPases and ERK activation. PMID: 22614672
    12. role of miR-125b in pro-metastasis by targeting STARD13 PMID: 22693547
    13. DLC2 inhibits the activity of Raf-1-ERK1/2-p70S6K via its RhoGAP function, resulting in the suppression of cell growth. PMID: 20629949
    14. has GAP activity specific for RhoA and Cdc42; inhibits the Rho mediated assembly of actin stress fibers in cultured cells and is underexpressed in hepatocellular carcinoma tissues PMID: 12531887
    15. underexpression is associated with poor prognosis in patients with hepatocellular carcinoma PMID: 18651974

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
  • 組織特異性:
    Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.
  • 數據庫鏈接:

    HGNC: 19164

    OMIM: 609866

    KEGG: hsa:90627

    STRING: 9606.ENSP00000338785

    UniGene: Hs.156551



主站蜘蛛池模板: 国产av久久久久精东av| 欧美私人情侣网站| 亚欧洲精品在线视频免费观看| 国产无遮挡a片无码免费| 中文乱码字幕高清一区二区 | 开心色怡人综合网站| 国内极度色诱视频网站| 人与嘼交av免费| 国产激情久久久久影院老熟女免费| 国内揄拍国内精品人妻浪潮av| 高中国产开嫩苞实拍视频在线观看| 亚洲 a v无 码免 费 成 人 a v| 天天天欲色欲色www免费| 成人看的污污超级黄网站免费| 韩国午夜福利片在线| 亚洲色欲色欲www在线看| 影视先锋av资源噜噜| 久久se精品一区精品二区 | 麻豆人妻无码性色av专区| 人妻无码精品久久亚瑟影视| 撕开奶罩揉吮奶头视频| 一区二区三区在线 | 网站| 亚洲成a∧人片在线观看无码| 国产成人a无码短视频| 51久久国产露脸精品国产| 久久欧美国产伦子伦精品| 国产精品无打码在线播放| 国产精品自在线拍亚洲另类| 一二三四社区在线中文视频| 99久久久国产精品无码免费| 国产精品三级国产电影| 久久天天躁狠狠躁夜夜2o2o| 国模冰莲自慰肥美胞极品人体图| 欧洲熟妇色xxxx欧美老妇| 国产av一区二区精品凹凸| 人妻无码中字在线a| 久久精品国产色蜜蜜麻豆| 成人啪啪高潮不断观看| 亚洲国产成人精品激情姿源 | 东京热人妻无码一区二区av| 丰满的少妇邻居中文bd |