Recombinant Human Son of sevenless homolog 1 (SOS1)
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中文名稱:
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貨號:CSB-YP726788HU
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規格:
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來源:Yeast
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其他:
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中文名稱:
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貨號:CSB-EP726788HU
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規格:
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來源:E.coli
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其他:
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中文名稱:
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貨號:CSB-EP726788HU-B
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規格:
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來源:E.coli
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共軛:Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他:
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中文名稱:
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貨號:CSB-BP726788HU
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規格:
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來源:Baculovirus
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其他:
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中文名稱:
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貨號:CSB-MP726788HU
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規格:
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來源:Mammalian cell
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其他:
產品詳情
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純度:>85% (SDS-PAGE)
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基因名:
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Uniprot No.:
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別名:Son of sevenless homolog 1; SOS-1; SOS1
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種屬:Homo sapiens (Human)
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蛋白標簽:Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式:Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet :Please contact us to get it.
相關產品
靶點詳情
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功能:Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity.
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基因功能參考文獻:
- a distinct role of the C-terminal proline-rich (PR) domain of the full-length son of sevenless homolog 1 (SOS1) protein. PMID: 28452363
- SOS1 was statistically significantly associated with gestational diabetes mellitus risk after adjusting for multiple comparisons PMID: 29233017
- Findings identified p.Ser548Arg missense mutation in Son of Sevenless Homolog 1 (SOS1) in the boy, confirmed in his mother. PMID: 28456002
- We report on a novel pathogenic mutation in the SOS1 gene and a large clinical spectrum in a Noonan syndrome family with ten genetically confirmed affected individuals. PMID: 28884940
- Data indicate dynamic of H-Ras functional cycle as controlled by son of sevenless homolog 1 (Sos). PMID: 27412770
- In summary, patients from two families with history of non-syndromic autosomal-dominant HGF from Malopolska and Mazovia provinces in Poland had not been affected by HGF type 1, caused by a single-cytosine insertion in exon 21 of the SOS-1 gene. PMID: 28425619
- Mutation scanning of the entire coding sequence of SOS1 gene identified seven intronic variants and one new exonic substitution (c.138G > A). The seven common intronic variants were not considered to be of pathogenic importance. The exonic substitution c.138G > A was found to be absent in 100 ethnically matched normal control chromosomes, not expected to have functional significance based on prediction bioinformatics tool PMID: 28433619
- Grb2-independent interactions are sufficient to retain human SOS on the membrane for many minutes, during which a single SOS molecule could processively activate thousands of Ras molecules. PMID: 27501536
- a computational methodology that overlays any variant database onto the somatic mutations in all cancer exomes identified activating SOS1 mutations associated with Noonan syndrome as significantly altered in melanoma PMID: 27304678
- Data show that a heterozygous son of sevenless homolog 1 (SOS1) gene frameshift mutation (c.3266dup or c.3248dup) was identified in each patient. PMID: 26708403
- Ras.GDP weakly binds to the catalytic but not to the allosteric site of Sos. PMID: 26565026
- The present study provides a first evidence of allelic imbalance of SOS1 and pinpoints this condition as a possible mechanism underlying a different penetrance of some SOS1-mutated alleles in unrelated carriers PMID: 25712082
- In non-apoptotic cells, nuclear EGFR induced SOS1 expression by directly binding to the SOS1 promoter. PMID: 25980493
- rs963731 is associated with corticobasal degeneration. PMID: 26077951
- findings suggest that targeting the Src/Abl/Sos1/Rac pathway may represent a double-edged sword to control both cancer-invasive capacities and cancer-related inflammation. PMID: 26447228
- These data demonstrated the negative regulation between miR-146a and SOS1 and between miR-370 and GADD45beta and that these regulations are influenced by enterovirus 71 to induce apoptosis. PMID: 25469565
- Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. PMID: 25825487
- SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1. PMID: 25394671
- HGF-related mutation g.126,142-126,143insC in exon 21 was not found in any of the 6 affected individuals from three families. PMID: 25062969
- Stabilized alpha helices of son of sevenless 1 directly inhibit wild-type and mutant forms of KRAS. PMID: 25624485
- CIIA functions as a negative modulator of the SOS1-Ras signaling events initiated by peptide growth factors including EGF. PMID: 24522193
- Increased expression of SOS1 increases NFkappaB activation in several types of cancer cells, and ablation of SOS1 inhibits EGF-induced NFkappaB activation in these cells, indicating that SOS1 is a component of the pathway connecting EGFR to NFkappaB activation. PMID: 25071181
- sustained Erk signaling and T-cell activation depend on both Sos1 and RasGRP1. PMID: 24497027
- MiR-124 inhibits the growth of glioblastoma through the downregulation of SOS1. PMID: 23817964
- Although Sos1 and Gab1 recognize two non-overlapping sites within the Grb2 adaptor, allostery promotes the formation of two distinct pools of Grb2-Sos1 and Grb2-Gab1 binary signaling complexes in lieu of a composite Sos1-Grb2-Gab1 ternary complex. PMID: 23334917
- The SOS1 T158A mutation altered the phosphorylation of gene products involved in both RAS/MAPK and PI3K/AKT pathways. PMID: 23528009
- The PR domain displays a highly dynamic conformational basin in agreement with the knowledge that the intrinsically unstructured proteins rapidly interconvert between an ensemble of conformations. PMID: 23528987
- study established that the presence of SOS1, but not its enzymatic activity, is critical for p38 activation PMID: 23589333
- Oncogenic K-Ras promotes the activation of wild-type H- and N-Ras and this activation is mediated by oncogenic K-Ras-dependent allosteric stimulation of Sos. PMID: 23132018
- T-cell antigen receptor (TCR)-mediated Erk activation requires RasGRP1, but not Grb2/Sos. PMID: 22344067
- Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2 PMID: 22396725
- We present a stochastic mathematical model describing intra-molecular regulation of hSos1 activity. PMID: 21851854
- multiple binding sites within Sos1 provide a physical route for Grb2 to hop in a flip-flop manner from one site to the next through facilitated diffusion, and such rapid exchange forms the basis of cooperativity driving bivalent binding of Grb2 to Sos1 PMID: 22360309
- SOS1 over-expression may play a role in the regulation of the RAS/mitogen-activated protein kinase pathway in the skin, in the hair follicle proliferation and cell cycle, suggesting new perspectives in understanding the pathogenesis of hirsutism. PMID: 22217993
- CIIA functions as a molecular switch for the GEF activity of SOS1, directing this activity toward Rac1. PMID: 22042618
- The researchers found evidence that there were significant differences between the D2S441 locus in the Maghreb population and other populations. PMID: 21674833
- this report expanded the available information about the molecular diversity of SOS1 mutations underlying Noonan syndrome, and have provided a more comprehensive assessment of the clinical features associated with those molecular lesions. PMID: 21387466
- Comparison of RasGEF expression at different developmental stages showed that relative to Sos2 and RasGRP1, Sos1 is most abundant in DN thymocytes, but least abundant in DP thymocytes. PMID: 21746917
- two unrelated patients with Noonan syndrome carrying the same heterozygous SOS1 missense mutation (c.1867T > A/p.F623I) PMID: 20673819
- A case mimicking CS with SOS1 T158A substitution, which has not been reported previously in CS, revealed the complex relationship between the genotype and phenotype of overlapping syndromes of the RAS/RAF/MEK/ERK pathway. PMID: 20030748
- This study investigated the regulation of the previously uncharacterized SOS1 gene promoter by the aryl hydrocarbon receptor and its ligands in HepG2 cells. PMID: 20950586
- mutation analysis performed on RAF1, SOS1, and GRB2, in 24 Noonan syndrome patients previously found to be negative for PTPN11 and KRAS mutations; SOS1 may have a role of modifier gene that might contribute the variable expressivity of the disease PMID: 20683980
- Noonan syndrome is due to a SOS1 missense mutation and rhabdomyosarcoma. PMID: 20607846
- Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK. PMID: 20724475
- Noonan-like/multiple giant cell lesion syndrome with mutations in the SOS1 gene PMID: 20305546
- Based on our results, it is possible that a subtle dysfunction (expression) of the SOS1 gene is involved in the development of the most common male reproductive tract disorder - unilateral or bilateral cryptorchidism PMID: 20389169
- a new crystal structure of SOS at 3.2 A resolution was presented that contains the histone domain and the DH-PH unit in addition to the catalytic segment (SOSHDPC, residues 1-1049). PMID: 20133692
- Sos-histone domain plays a critical role in governing the catalytic output of Sos through the coupling of membrane recruitment to the release of autoinhibition. PMID: 20133694
- First report describing different tumor types in Noonan syndrome with germline SOS1 mutations. PMID: 19953625
- The binding of Grb2 adaptor to its downstream partners Sos1 and Gab1 docker is under tight allosteric regulation. PMID: 20005866
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相關疾病:Fibromatosis, gingival, 1 (GINGF1); Noonan syndrome 4 (NS4)
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組織特異性:Expressed in gingival tissues.
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