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  4. Recombinant Human Sodium- and chloride-dependent taurine transporter (SLC6A6), partial

Recombinant Human Sodium- and chloride-dependent taurine transporter (SLC6A6), partial

  • 中文名稱：
    人SLC6A6重組蛋白
  • 貨號：
    CSB-YP021704HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLC6A6重組蛋白
  • 貨號：
    CSB-EP021704HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLC6A6重組蛋白
  • 貨號：
    CSB-EP021704HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLC6A6重組蛋白
  • 貨號：
    CSB-BP021704HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLC6A6重組蛋白
  • 貨號：
    CSB-MP021704HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    MGC10619; MGC131729; OTTHUMP00000208177; OTTHUMP00000208180; SC6A6_HUMAN; SLC6A6; Sodium- and chloride-dependent taurine transporter; Solute carrier family 6 (neurotransmitter transporter, taurine), member 6; Solute carrier family 6 member 6; TAUT
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.
  • 基因功能參考文獻：
    1. TauT gene expression is significantly upregulated in mononuclear leukocytes of type 1 diabetes patients and is related to HbA1c levels and inversely to plasma homocysteine. PMID: 26955642
    2. CNDP1 and CARNS are expressed in glomeruli and tubular cells; TauT is expressed in renal epithelial cells; CDNP1 may have a role in diabetic neuropathy PMID: 26206726
    3. This is the first study to present information on the transcriptional regulation of taurine transporter gene and the localization of the taurine transporter protein in chondrocytic cells. PMID: 25501278
    4. Neurotransmitter transporters including SLC6A6 and SLC6A13 mediate the uptake of 5-aminolevulinic acid (ALA) and can play roles in the enhancement of ALA-induced accumulation of protoporphyrin in cancerous cells. PMID: 24842606
    5. Immunocytochemistry and flow cytometry analyses revealed that these mAbs recognized the native form of the extracellular domain of SLC6A6 on the cell surface. PMID: 24866236
    6. Taurine transporter is a novel pathological marker for stressed motor neurons in amyotrophic lateral sclerosis. PMID: 23180277
    7. Taurine transporter deficiency results in aberrant trophoblast turnover and fetal growth restriction. PMID: 23519128
    8. Syncytiotrophoblast TauT activity is reduced in maternal obesity and pre-eclampsia compared to normal pregnancy. PMID: 23392873
    9. Knockdown of TauT impairs kidney development, possibly through regulation of cell cycle-related genes. PMID: 23392892
    10. TauT gene is overexpressed in peripheral blood mononuclear cells of type 2 diabetic patients. PMID: 21739148
    11. TNF-alpha-treated cells showed a higher mRNA level of the TAUT (taurine transporter) than did the control cells. PMID: 12062416
    12. TauT is involved with p53 in renal development and apoptosis. PMID: 12163498
    13. regulation by WT1 PMID: 12681485
    14. nitric oxide plays an important role in downregulating microvillous plasma membrane taurine transporter activity in intrauterine growth restriction PMID: 15166008
    15. The increased expression level of TAUT mRNA by hypertonicity was repressed by the specific Ca(2+)/CaM kinase II inhibitor. PMID: 15225620
    16. TAUT activity in TNF-alpha-treated Caco-2 cells suggests that up-regulation was associated with an increase in the amount of TAUT. PMID: 15630186
    17. reporter assay revealed that TNF-alpha-induced TAUT transcriptional activity through the NF-kappaB consensus-like sequence in the human TAUT promoter region PMID: 15907840
    18. taurine cotransporter is regulated by oxidative stress and overexpression of aldose reductase and high glucose impair this response PMID: 16356117
    19. Greater system beta activity in fetal platelets compared with T lymphocytes is the result of relatively greater TAUT mRNA and protein expression. PMID: 16956961
    20. Report taurine transporter activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
    21. This study demonstrates the functional coexpression of TauT along with the PAT1 transporter (SLC36A1) at the apical membrane of the intestinal epithelium. PMID: 19074966
    22. critical role in protecting against cisplatin-induced nephrotoxicity, possibly by attenuating a p53-dependent pathway PMID: 19423693
    23. Glucose reduced taurine transporter (TauT) mRNA and protein in a dose-dependent manner. PMID: 19602579

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A6 subfamily
  • 組織特異性：
    Expressed abundantly in placenta and skeletal muscle, at intermediate levels in heart, brain, lung, kidney and pancreas and at low levels in liver.
  • 數據庫鏈接：

    HGNC: 11052

    OMIM: 186854

    KEGG: hsa:6533

    STRING: 9606.ENSP00000354107

    UniGene: Hs.529488



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