在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Single Ig IL-1-related receptor (SIGIRR), partial

Recombinant Human Single Ig IL-1-related receptor (SIGIRR), partial

  • 中文名稱：
    人SIGIRR重組蛋白
  • 貨號：
    CSB-YP743558HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SIGIRR重組蛋白
  • 貨號：
    CSB-EP743558HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SIGIRR重組蛋白
  • 貨號：
    CSB-EP743558HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SIGIRR重組蛋白
  • 貨號：
    CSB-BP743558HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ig IL1 related receptor; MGC110992; SIGIR_HUMAN; SIGIRR; Single Ig IL 1 related receptor; Single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; Single Ig IL1R Related Molecule; Single immunoglobulin and toll interleukin 1 receptor (TIR) domain; Single immunoglobulin and toll interleukin 1 receptor domain; Single immunoglobulin domain containing IL1R related protein; Single immunoglobulin domain IL1R1 related; Single immunoglobulin domain-containing IL1R-related protein; TIR 8; TIR8; Toll/interleukin 1 receptor 8; Toll/interleukin-1 receptor 8
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
  • 基因功能參考文獻：
    1. SIGIRR is both a negative regulator of TLR4 and a positive regulator of TLR7/8. PMID: 28869081
    2. Our results indicate that high IL-1R8 expression acts as a novel immunomodulatory mechanism leading to dysregulated immunity with important implications for breast cancer immunotherapy. PMID: 28533483
    3. show by flow cytometry analysis, western blot, confocal microscopy, and quantitative real-time polymerase chain reaction that IL-1R8 is expressed on human and mouse platelets at high levels and on megakaryocytes. IL-1R8-deficient mice show normal levels of circulating platelets PMID: 27297888
    4. Tir8/SIGIRR acts anti-inflammatory on different immune responses,its function in allergic asthma is a controversial issue, since anti- as well as pro-inflammatory effects have been reported PMID: 26561030
    5. SIGIRR plays an important role in the negative regulation of LPS response and tolerance in human bladder epithelial cells, possibly through its impact on TLR-mediated signaling. PMID: 26634342
    6. Levels of SIGIRR are lower in human colorectal tumors, compared with nontumor tissues; tumors contain the dominant-negative isoform SIGIRR(DeltaE8). PMID: 26344057
    7. SIGIRR predicts biochemical recurrence in patients with low Gleason score and low pathological stage prostate cancer. PMID: 26344417
    8. decreased numbers of SIGIRR-positive CD4+ T cells in SLE patients and its correlation with SLEDAI score as well as the clinical data suggest that SIGIRR may be involved in the pathogenesis of SLE. PMID: 25287661
    9. To the best of our knowledge, this is one of the first reports of a phenotype associated with SIGIRR in humans. Our data provide novel mechanistic insight into the probable causation of necrotizing enterocolitis PMID: 25963006
    10. An association was found in the SIGIRR rs7396562 polymorphism and systemic lupus erythematosus susceptibility in a Chinese population. PMID: 24826913
    11. IL-37 requires the receptors IL-18Ralpha and IL-1R8 to carry out its multifaceted anti-inflammatory program upon innate signal transduction. PMID: 25729923
    12. IL-37 acts as an extracellular cytokine by binding to the IL-18 receptor but using the IL-1R8 for its anti-inflammatory properties. PMID: 25654981
    13. Lipopolysaccharide decreases SIGIRR expression by suppressing specificity protein 1 Sp1 via the TLR4-p38 pathway in monocytes and neutrophils. PMID: 24821721
    14. the tested variations of IRAK-M and SIGIRR genes do not confer a relevant role in the susceptibility to systemic lupus erythematosus in European-descent populations PMID: 22634523
    15. These results demonstrate a strong association of single-nucleotide polymorphisms in the PKP3-SIGIRR-TMEM16J gene region and tuberculosis in discovery and validation cohorts. PMID: 22223854
    16. These results suggest that PALM3 may function as an adaptor in the LPS- Toll-like receptor 4 signaling and the interaction of SIGIRR with PALM3 may partly account for the mechanism of the negatively regulatory effect of SIGIRR. PMID: 21187075
    17. SIGIRR is expressed constitutively in intestinal epithelial cells to maintain gut innate immunity and then down-regulated during inflammation by inhibition of an SP1-mediated pathway. PMID: 21077278
    18. SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis PMID: 20506350
    19. regulatory functions in inflammation and Th1/Th2 cell polarization (Review) PMID: 19699681
    20. SIGIRR inhibits IL-1R and TLR4-mediated signaling through different mechanisms PMID: 15866876

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Single-pass type III membrane protein.
  • 蛋白家族：
    Interleukin-1 receptor family
  • 組織特異性：
    Mainly expressed in epithelial tissues such as kidney, lung and gut.
  • 數據庫鏈接：

    HGNC: 30575

    OMIM: 605478

    KEGG: hsa:59307

    STRING: 9606.ENSP00000333656

    UniGene: Hs.501624



主站蜘蛛池模板： 免费午夜爽爽爽www视频十八禁| 一本色道久久88精品综合| 国产精品无码免费专区午夜| 亚洲精品国产福利一区二区| 国产午夜鲁丝无码拍拍| 亚洲精品无码成人片| 欧洲亚洲国产成人综合色婷婷| 国产综合18久久久久久| 四虎国产精品永久在线观看| 中日韩高清无专码区2021| 亚洲色婷婷婷婷五月基地 | 4399理论片午午伦夜理片| 国产h视频在线观看| 欧美极p品少妇的xxxxx| 欧美丰满老熟妇乱叫| 天天狠天天透天天伊人| 色婷婷综合中文久久一本| 亚洲国产婷婷香蕉久久久久久| 无码av岛国片在线播放| 久久一日本综合色鬼综合色| 欧美性白人极品hd| 亚洲午夜精品一区二区| 婷婷俺也去俺也去官网| 国产精品天天看特色大片| 久久久精品午夜免费不卡| 午夜精品久久久久久久久| 色老头av亚洲一区二区男男| 午夜免费啪视频观看视频| 人妻无码第一区二区三区| 樱花影院电视剧免费| 人妻护士在线波多野结衣| 免费无码午夜理论电影| 国产免费又爽又色又粗视频| 久99久热只有精品国产女同| 久久人人97超碰a片精品| 亚洲国产精华液网站w| 一区二区三区视频| 亚洲熟女乱综合一区二区在线| 亚洲精品av一区在线观看| 男女后进式猛烈xx00动态图片| 丝袜老师办公室里做好紧好爽|