在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Serine/threonine-protein kinase RIO2 (RIOK2)

  • 中文名稱:
    人RIOK2重組蛋白
  • 貨號:
    CSB-YP887136HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RIOK2重組蛋白
  • 貨號:
    CSB-EP887136HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人RIOK2重組蛋白
  • 貨號:
    CSB-EP887136HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RIOK2重組蛋白
  • 貨號:
    CSB-BP887136HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RIOK2重組蛋白
  • 貨號:
    CSB-MP887136HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    RIOK2
  • Uniprot No.:
  • 別名:
    FLJ11159; OTTHUMP00000158911; OTTHUMP00000222868; RIO kinase 2 (yeast) ; RIO kinase 2; RIO2; RIOK2; RIOK2_HUMAN; Serine/threonine protein kinase RIO2; Serine/threonine-protein kinase rio2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-552
  • 氨基酸序列
    MGKVNVAKLR YMSRDDFRVL TAVEMGMKNH EIVPGSLIAS IASLKHGGCN KVLRELVKHK LIAWERTKTV QGYRLTNAGY DYLALKTLSS RQVVESVGNQ MGVGKESDIY IVANEEGQQF ALKLHRLGRT SFRNLKNKRD YHKHRHNVSW LYLSRLSAMK EFAYMKALYE RKFPVPKPID YNRHAVVMEL INGYPLCQIH HVEDPASVYD EAMELIVKLA NHGLIHGDFN EFNLILDESD HITMIDFPQM VSTSHPNAEW YFDRDVKCIK DFFMKRFSYE SELFPTFKDI RREDTLDVEV SASGYTKEMQ ADDELLHPLG PDDKNIETKE GSEFSFSDGE VAEKAEVYGS ENESERNCLE ESEGCYCRSS GDPEQIKEDS LSEESADARS FEMTEFNQAL EEIKGQVVEN NSVTEFSEEK NRTENYNRQD GQRVQGGVPA GSDEYEDECP HLIALSSLNR EFRPFRDEEN VGAMNQYRTR TLSITSSGSA VSCSTIPPEL VKQKVKRQLT KQQKSAVRRR LQKGEANIFT KQRRENMQNI KSSLEAASFW GE
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function.
  • 基因功能參考文獻:
    1. These results suggested that RIOK2 and NOB1 may be potential targets in the treatment of Non-small cell lung cancer (NSCLC), and miR145 may be considered a therapeutic inhibitor of both genes. PMID: 29749434
    2. RIOK2 and NOB1 were highly expressed in NSCLC cells and tissues, and their expression profiles were significantly associated with the Tumour Node Metastasis (TNM) clinical stage, lymph node metastasis, and differentiation. RIOK2 expression was correlated with NOB1. PMID: 27346559
    3. As RIO2 is involved in the biosynthesis of the ribosome and cell cycle regulation, our selective ligand may be useful for the delineation of the biological role of this kinase. PMID: 25891899
    4. reduced expression of RIOK1 or RIOK2 disrupted Akt signaling and caused cell cycle exit, apoptosis, and chemosensitivity in glioblastoma cells PMID: 23459592
    5. Plk1-mediated phosphorylation of Rio2 regulates metaphase-anaphase transition during mitotic progression. PMID: 21880710
    6. Results show that the protein kinase human Rio2 (hRio2) is part of a late 40S preribosomal particle in human cells. PMID: 19564402

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, RIO-type Ser/Thr kinase family
  • 數據庫鏈接:

    HGNC: 18999

    OMIM: 617754

    KEGG: hsa:55781

    STRING: 9606.ENSP00000283109

    UniGene: Hs.27021



主站蜘蛛池模板: 久99久无码精品视频免费播放| 国产精品高清网站| 久久不见久久见免费影院3| 女人被狂躁到高潮视频免费软件| 天天躁日日躁狠狠久久| 亚洲欧美人成网站aaa| 4hu亚洲人成人无码网www电影首页| 欧美乱妇高清无乱码| 日本免费人成视频播放| 蜜臀av在线无码国产| 东北妇女xx做爰视频| 18禁在线永久免费观看| 狠狠人妻久久久久久综合| 免费女上男下xx00xx00视频| 国产成_人_综合_亚洲_国产| 亚洲va国产va天堂va久久| 中文字幕日本特黄aa毛片| 日本少妇无码精品12p| 人妻少妇久久中文字幕| 西西人体www大胆高清| 精品无码欧美黑人又粗又| 精品国产午夜福利在线观看| 天天爽夜夜爽人人爽| 人妻中文字幕乱人伦在线| 国内精品伊人久久久久影院对白| 国产成人精品手机在线观看| 国产成人久久精品77777综合| 国产成人精品.视频| 国产成年码av片在线观看| 国产人妖乱国产精品人妖| 男女性杂交内射妇女bbwxz| av无码动漫一区二区三区精品| 亚洲精品第一区二区三区| 精品乱码一区二区三区四区| 中文字幕卡二和卡三的视频| 7777奇米成人狠狠成人影视| 日本熟妇浓毛| 丝袜无码一区二区三区| 欧美白人最猛性xxxxx| 欧美疯狂做受xxxx高潮| 久久er热在这里只有精品66|