在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Serine/threonine-protein kinase RIO2 (RIOK2)

  • 中文名稱:
    人RIOK2重組蛋白
  • 貨號:
    CSB-YP887136HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RIOK2重組蛋白
  • 貨號:
    CSB-EP887136HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人RIOK2重組蛋白
  • 貨號:
    CSB-EP887136HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RIOK2重組蛋白
  • 貨號:
    CSB-BP887136HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RIOK2重組蛋白
  • 貨號:
    CSB-MP887136HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    RIOK2
  • Uniprot No.:
  • 別名:
    FLJ11159; OTTHUMP00000158911; OTTHUMP00000222868; RIO kinase 2 (yeast) ; RIO kinase 2; RIO2; RIOK2; RIOK2_HUMAN; Serine/threonine protein kinase RIO2; Serine/threonine-protein kinase rio2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-552
  • 氨基酸序列
    MGKVNVAKLR YMSRDDFRVL TAVEMGMKNH EIVPGSLIAS IASLKHGGCN KVLRELVKHK LIAWERTKTV QGYRLTNAGY DYLALKTLSS RQVVESVGNQ MGVGKESDIY IVANEEGQQF ALKLHRLGRT SFRNLKNKRD YHKHRHNVSW LYLSRLSAMK EFAYMKALYE RKFPVPKPID YNRHAVVMEL INGYPLCQIH HVEDPASVYD EAMELIVKLA NHGLIHGDFN EFNLILDESD HITMIDFPQM VSTSHPNAEW YFDRDVKCIK DFFMKRFSYE SELFPTFKDI RREDTLDVEV SASGYTKEMQ ADDELLHPLG PDDKNIETKE GSEFSFSDGE VAEKAEVYGS ENESERNCLE ESEGCYCRSS GDPEQIKEDS LSEESADARS FEMTEFNQAL EEIKGQVVEN NSVTEFSEEK NRTENYNRQD GQRVQGGVPA GSDEYEDECP HLIALSSLNR EFRPFRDEEN VGAMNQYRTR TLSITSSGSA VSCSTIPPEL VKQKVKRQLT KQQKSAVRRR LQKGEANIFT KQRRENMQNI KSSLEAASFW GE
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function.
  • 基因功能參考文獻:
    1. These results suggested that RIOK2 and NOB1 may be potential targets in the treatment of Non-small cell lung cancer (NSCLC), and miR145 may be considered a therapeutic inhibitor of both genes. PMID: 29749434
    2. RIOK2 and NOB1 were highly expressed in NSCLC cells and tissues, and their expression profiles were significantly associated with the Tumour Node Metastasis (TNM) clinical stage, lymph node metastasis, and differentiation. RIOK2 expression was correlated with NOB1. PMID: 27346559
    3. As RIO2 is involved in the biosynthesis of the ribosome and cell cycle regulation, our selective ligand may be useful for the delineation of the biological role of this kinase. PMID: 25891899
    4. reduced expression of RIOK1 or RIOK2 disrupted Akt signaling and caused cell cycle exit, apoptosis, and chemosensitivity in glioblastoma cells PMID: 23459592
    5. Plk1-mediated phosphorylation of Rio2 regulates metaphase-anaphase transition during mitotic progression. PMID: 21880710
    6. Results show that the protein kinase human Rio2 (hRio2) is part of a late 40S preribosomal particle in human cells. PMID: 19564402

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, RIO-type Ser/Thr kinase family
  • 數據庫鏈接:

    HGNC: 18999

    OMIM: 617754

    KEGG: hsa:55781

    STRING: 9606.ENSP00000283109

    UniGene: Hs.27021



主站蜘蛛池模板: 18禁肉肉无遮挡无码网站| 精品久久无码中文字幕| 97久久久人妻一区精品| 午夜无码性爽快影院6080| 中文字幕av一区| 最爽无遮挡行房视频| 亚洲精品综合欧美一区二区三区| 久久久久国产精品人妻| 日韩免费无砖专区2020狼| 亚洲日韩一页精品发布| 国产乱人伦真实精品视频| 亚洲欧美色αv在线影视| 国产在线视频www色| 少女高清影视在线观看动漫| 无码专区一va亚洲v专区在线| 国产在线播放精品视频| 亚洲综合国产成人丁香五月激情| 三级成年网站在线观看级爱网| 亚洲精华国产精华精华液网站| 欧美性xxxxx极品少妇| 亚洲欧洲日产国产 最新| 国产精品兄妹在线观看麻豆| √天堂资源中文| 亚洲精品一区二区三区新线路 | 337p日本欧洲亚洲大胆色噜噜| 精品人无码一区二区三区| av激情亚洲男人的天堂| 99精品无人区乱码在线观看| 久久偷看各类wc女厕嘘嘘| 侵犯强奷高清无码| 中文无码精品a∨在线观看不卡| 特黄特色大片免费播放器图片| 久久精品国产99久久无毒不卡| 国产a国产片国产| 法国伦理少妇愉情| 中文无码精品a∨在线观看| 亚洲欧美中文日韩在线v日本 | 日本熟妇人妻xxxxx-欢迎您| 豆国产96在线 | 亚洲| 国产人妻久久精品二区三区| 亚洲国产精品自产在线播放|