在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Sepiapterin reductase (SPR), Biotinylated

In Stock
  • 中文名稱:
    Recombinant Human Sepiapterin reductase (SPR), Biotinylated
  • 品名簡稱:
    Recombinant Human SPR protein, Biotinylated
  • 貨號:
    CSB-EP022605HU-B
  • 說明書:
  • 規(guī)格:
    ¥2832
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    SPR
  • Uniprot No.:
  • 別名:
    SPR
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    75.8 kDa
  • 表達(dá)區(qū)域:
    1-261aa
  • 氨基酸序列
    MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
  • 基因功能參考文獻(xiàn):
    1. The allele frequencies for the SPR c.596-2A > G (0.7%) polymorphism is not a major cause of Parkinson's disease in the Maltese. PMID: 27613114
    2. We earlier presented evidence for a physical interaction between ODC and SPR and we showed that RNAi-mediated knockdown of SPR expression significantly reduced native ODC enzyme activity and impeded Neuroblastoma cell proliferation. PMID: 26093909
    3. new homozygous mutation in the SPR gene was found in two sisters with dopa-responsive dystonia PMID: 24588500
    4. Authors identified SPR as a novel regulator of ODC enzyme activity and, based on clinical evidence, present a model in which SPR drives ODC-mediated malignant progression in neuroblastoma. PMID: 24096079
    5. SPR-mediated reduction of sepiapterin and redox cycling occur by distinct mechanisms PMID: 23640889
    6. SRD can manifest as early-onset parkinsonism, widening the spectrum of the disease phenotype and adding to the genetic heterogeneity of the disease PMID: 22018912
    7. this large association study for the SPR gene revealed no association for Parkinson disease worldwide. PMID: 21782285
    8. We examine the sleep, sleep-wake rhythms, CSF neurotransmitters, and melatonin profile in a patient with sepiapterin reductase deficiency. PMID: 20337188
    9. haploinsufficiency of SPR can be a rare cause of dopa-responsive dystonia PMID: 15241655
    10. Potentially modulates the onset of or risk for Parkinson's disease. PMID: 16443856
    11. Although association of SPR to Parkinson's disease (PD) is not strong enough to support that this is the PARK3 gene, this study further implicates a role for SPR in idiopathic PD. PMID: 17270157
    12. Genomic DNA revealed the same homozygous point mutation introducing a premature stop codon in the SPR gene in 2 siblings. PMID: 18502672
    13. This reduced transcription rate for SPR promoter haplotypes 2 and 3 may impact on antidepressant response and susceptibility to bipolar disorder. PMID: 19415819

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Dystonia, DOPA-responsive, due to sepiapterin reductase deficiency (DRDSPRD)
  • 亞細(xì)胞定位:
    Cytoplasm.
  • 蛋白家族:
    Sepiapterin reductase family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11257

    OMIM: 182125

    KEGG: hsa:6697

    STRING: 9606.ENSP00000234454

    UniGene: Hs.301540



主站蜘蛛池模板: 长腿校花无力呻吟娇喘| 国产边打电话边被躁视频| 久久婷婷五月综合色中文字幕| 法国白嫩大屁股xxxx| 欧美xxxx做受欧美69| 18禁无遮挡无码国产免费网站| 国产精品无码av一区二区三区 | 欧美z0zo人禽交免费观看99| 国产福利视频在线观看| 久久发布国产伦子伦精品| 无码中文字幕人妻在线一区 | 麻豆人妻少妇精品无码专区| 国产午夜精品一区二区三区极品| 亚洲无线码一区二区三区| 日本高清色倩视频在线观看| 国产超碰人人爽人人做| 久久精品亚洲男人的天堂| 精品无码成人片一区二区| 国产精品久久久久久亚洲毛片 | 成人亚洲a片v一区二区三区蜜臀| 色婷婷狠狠97成为人免费| 国产成人无码a区在线观看视频 | 夜夜躁狠狠躁日日躁202| 亚洲成年看片在线观看| 国精无码欧精品亚洲一区| 人人爽人人爽人人片av| 亚洲精品入口一区二区乱麻豆精品| 午夜无码人妻av大片色欲| 国产一区二区不卡老阿姨| 看国产黄大片在线观看| 一本色道久久88精品综合| 青青久在线视频免费观看| 久久99精品国产麻豆蜜芽| 乌克兰性欧美精品高清| 日本一区二区三区免费高清| 国产成人综合色在线观看网站| 亚洲乱码卡一卡二卡| 国产在线一区二区三区四区五区| 亚洲色成人网站www永久四虎| 午夜亚洲乱码伦小说区69堂| 亚洲欧洲美洲在线观看|