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  4. Recombinant Human SLIT and NTRK-like protein 1 (SLITRK1), partial

Recombinant Human SLIT and NTRK-like protein 1 (SLITRK1), partial

  • 中文名稱：
    人SLITRK1重組蛋白
  • 貨號：
    CSB-YP842740HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLITRK1重組蛋白
  • 貨號：
    CSB-EP842740HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLITRK1重組蛋白
  • 貨號：
    CSB-EP842740HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLITRK1重組蛋白
  • 貨號：
    CSB-BP842740HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLITRK1重組蛋白
  • 貨號：
    CSB-MP842740HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SLITRK1
  • Uniprot No.：
  • 別名：
    SLITRK1; KIAA1910; LRRC12; UNQ233/PRO266; SLIT and NTRK-like protein 1; Leucine-rich repeat-containing protein 12
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    It is involved in synaptogenesis and promotes excitatory synapse differentiation. Enhances neuronal dendrite outgrowth.
  • 基因功能參考文獻：
    1. Altogether, these results demonstrate that Slitrk family proteins regulate synapse formation. PMID: 27273464
    2. Data provide partial support for the implication of SLITRK1 in the pathogenesis of Tourette syndrome. PMID: 26317387
    3. the N400I variant of SLITRK1 may have a role in obsessive-compulsive disorder PMID: 23990902
    4. The study of chromosomal aberrations in Tourette syndrome etiology has implicated multiple genes, with SLITRK1 being the most prominent example. PMID: 23333760
    5. One of the few genes that has been linked to TS is the SLITRK1 (Slit and Trk-like 1) gene, where four variations have been suggested as possible disease-associated changes PMID: 23528612
    6. DM1 motoneuron/muscle cell cocultures showed alterations that are consistent with the known role of SLITRK genes in neurite outgrowth, neuritogenesis, and synaptogenesis; functional defects can be directly attributed to SLITRK misexpression. PMID: 21458401
    7. The study of this study support that SLITRK1 var321 is association to Tourette syndrome. PMID: 20351724
    8. findings support the association of rare SLITRK1 sequence variants with Tourette's syndrome PMID: 16224024
    9. SLITRK1 trouble in Tourette's syndrome. PMID: 16323357
    10. No variation in patients susceptible to obsessive-compulsive disorder.( PMID: 16936762
    11. Rare variations in SLITRK1 result in disorders of the obsessive-complusive disease spectrum PMID: 17003809
    12. negative results of the SLITRK1 analysis point to genetic heterogeneity in Tourette syndrome PMID: 17712845
    13. identified four new variants for Gilles de la Tourette syndrome PMID: 18004766
    14. Genetic screening in the Slit and Trk-like 1 gene for the recently identified mutations does not appear to be of utility in the diagnosis of Tourette syndrome. PMID: 18021920
    15. Observed transmission is lacking of SLITRK1 var321 from an affected parent to a child with Tourette syndrome in two families segregating this variant. PMID: 18413575
    16. These findings provide the first support for the original finding indicating SLITRK1 as a susceptibility gene for Gilles de la Tourette Syndrome PMID: 18698576
    17. We report the psychopathological features in a large Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 gene. PMID: 18722020
    18. results provide no evidence for SLITRK1 playing a major role in Tourette disease PMID: 19018236

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  • 相關疾病：
    Trichotillomania (TTM)
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein. Secreted. Cell junction, synapse.
  • 蛋白家族：
    SLITRK family
  • 組織特異性：
    Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.
  • 數據庫鏈接：

    HGNC: 20297

    OMIM: 609678

    KEGG: hsa:114798

    STRING: 9606.ENSP00000366288

    UniGene: Hs.415478



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