在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human SH3 and multiple ankyrin repeat domains protein 1 (SHANK1), partial

  • 中文名稱:
    人SHANK1重組蛋白
  • 貨號:
    CSB-YP897558HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人SHANK1重組蛋白
  • 貨號:
    CSB-EP897558HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人SHANK1重組蛋白
  • 貨號:
    CSB-EP897558HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人SHANK1重組蛋白
  • 貨號:
    CSB-BP897558HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人SHANK1重組蛋白
  • 貨號:
    CSB-MP897558HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    GKAP/SAPAP interacting protein; OTTHUMP00000174437; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SH3/ankyrin domain gene 1; SHAN1_HUMAN; SHANK 1; Shank1; Shank1a; Somatostatin receptor interacting protein; Somatostatin receptor-interacting protein; SPANK 1; SPANK1; SSTR interacting protein; SSTR-interacting protein; SSTRIP; Synamon
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
  • 基因功能參考文獻:
    1. Authors summarize and discuss behavioral and neuronal findings obtained in the Shank1 knockout mouse model for Autism spectrum disorder (ASD); identify open research questions by comparing such findings with the symptoms present in humans diagnosed with ASD and carrying SHANK1 deletions; conclude by discussing the implications of the behavioral and neuronal phenotypes displayed by the Shank1 knockout mouse model. PMID: 28963042
    2. SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN domain and thus limiting their bioavailability at the plasma membrane. PMID: 28263956
    3. Data show that the Shank1 protein mRNA 3' UTR adopts two very stable intramolecular G-quadruplexes which are bound specifically and with high affinity by X mental retardation protein (FMRP). PMID: 25692235
    4. a non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA PMID: 24533096
    5. The results of this study suggested a role of SHANK1 in working memory deficits in schizophrenia. PMID: 21901269
    6. A hemizygous SHANK1 deletion segregates in a four-generation family in which male carriers--but not female carriers--have autism spectrum disorder with higher functioning. PMID: 22503632
    7. Results show that dendritic targeting of shank1 mRNA granules involves KIF5C and the KIF5-associated RNA-binding protein staufen1. PMID: 19416473

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
  • 蛋白家族:
    SHANK family
  • 組織特異性:
    Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.
  • 數據庫鏈接:

    HGNC: 15474

    OMIM: 604999

    KEGG: hsa:50944

    STRING: 9606.ENSP00000293441

    UniGene: Hs.274255



主站蜘蛛池模板: 久久国产成人午夜av影院| 伊人av超碰伊人久久久| 亚洲 a v无 码免 费 成 人 a v | 亚欧成人无码av在线播放| 久久久亚洲一区二区三区| 精品国精品国产自在久国产87| 亚洲中文字幕在线第二页 | 思思99re6国产在线播放| 熟女人妻高清一区二区三区| 永久免费观看国产裸体美女| 国外av无码精品国产精品| 久久婷婷综合激情亚洲狠狠| 男女扒开双腿猛进入免费看污| 熟妇高潮精品一区二区三区| 麻豆国产人妻欲求不满谁演的| 国产在线视频精品视频| 无码日日模日日碰夜夜爽| 色综合久久网| 性人久久网av| 欧美高潮喷水大叫| 婷婷五月综合色中文字幕| 吸咬奶头狂揉60分钟视频| √最新版天堂资源在线| 国产按头口爆吞精在线视频| 一本加勒比hezyo无码专区| 日韩欧美一区二区三区免费观看| 国产清纯白嫩初高生在线观看 | 亚洲大成色www永久网站动图| 99久久国产综合精品五月天| 国产精品国产三级国产专区53| 国产精品久久久久久久久岛| 久久精品国产99久久久小说| 精品国模一区二区三区| 国产精品久久久久9999小说| 最新网站亚洲人成无码| 中文字幕欧美亚州视频免费| 美女视频黄是免费| 99re6热精品视频在线观看| 午夜免费啪视频观看视频| 成年美女黄网站色大免费视频| 亚洲精品国产嫩草在线观看东京热|