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SHANK1 Antibody

  • 中文名稱:
    SHANK1兔多克隆抗體
  • 貨號:
    CSB-PA021247GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    GKAP/SAPAP interacting protein antibody; OTTHUMP00000174437 antibody; SH3 and multiple ankyrin repeat domains 1 antibody; SH3 and multiple ankyrin repeat domains protein 1 antibody; SH3/ankyrin domain gene 1 antibody; SHAN1_HUMAN antibody; SHANK 1 antibody; Shank1 antibody; Shank1a antibody; Somatostatin receptor interacting protein antibody; Somatostatin receptor-interacting protein antibody; SPANK 1 antibody; SPANK1 antibody; SSTR interacting protein antibody; SSTR-interacting protein antibody; SSTRIP antibody; Synamon antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human SHANK1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
  • 基因功能參考文獻:
    1. Authors summarize and discuss behavioral and neuronal findings obtained in the Shank1 knockout mouse model for Autism spectrum disorder (ASD); identify open research questions by comparing such findings with the symptoms present in humans diagnosed with ASD and carrying SHANK1 deletions; conclude by discussing the implications of the behavioral and neuronal phenotypes displayed by the Shank1 knockout mouse model. PMID: 28963042
    2. SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN domain and thus limiting their bioavailability at the plasma membrane. PMID: 28263956
    3. Data show that the Shank1 protein mRNA 3' UTR adopts two very stable intramolecular G-quadruplexes which are bound specifically and with high affinity by X mental retardation protein (FMRP). PMID: 25692235
    4. a non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA PMID: 24533096
    5. The results of this study suggested a role of SHANK1 in working memory deficits in schizophrenia. PMID: 21901269
    6. A hemizygous SHANK1 deletion segregates in a four-generation family in which male carriers--but not female carriers--have autism spectrum disorder with higher functioning. PMID: 22503632
    7. Results show that dendritic targeting of shank1 mRNA granules involves KIF5C and the KIF5-associated RNA-binding protein staufen1. PMID: 19416473

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  • 亞細胞定位:
    Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
  • 蛋白家族:
    SHANK family
  • 組織特異性:
    Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.
  • 數據庫鏈接:

    HGNC: 15474

    OMIM: 604999

    KEGG: hsa:50944

    STRING: 9606.ENSP00000293441

    UniGene: Hs.274255



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