在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Run domain Beclin-1 interacting and cystein-rich containing protein (KIAA0226), partial

  • 中文名稱:
    人RUBCN重組蛋白
  • 貨號:
    CSB-YP856415HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RUBCN重組蛋白
  • 貨號:
    CSB-EP856415HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人RUBCN重組蛋白
  • 貨號:
    CSB-EP856415HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RUBCN重組蛋白
  • 貨號:
    CSB-BP856415HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RUBCN重組蛋白
  • 貨號:
    CSB-MP856415HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Baron; Beclin 1 associated RUN domain containing protein; Beclin-1 associated RUN domain containing protein; hypothetical protein LOC9711; Kiaa0226; OTTHUMP00000208021; OTTHUMP00000208023; OTTHUMP00000208024; RUBIC_HUMAN; Rubicon; RUN domain and cysteine rich domain containing, Beclin 1 interacting protein; Run domain Beclin 1 interacting and cystein rich containing protein; Run domain Beclin-1 interacting and cysteine-rich containing protein; RUN domain protein as Beclin 1 interacting and cysteine rich containing
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation.; Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines. Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or DDX58/RIG-I-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes.
  • 基因功能參考文獻:
    1. Rubicon thus functions as an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion. PMID: 28392573
    2. This study demonistrated that KIAA0226 mutation impairs Rubicon endosomal localization PMID: 23728897
    3. New DNA sequencing technologies are enabling us to investigate the whole or large targeted proportions of the genome in a rapid, affordable, and comprehensive way. Exome and targeted sequencing rundataxin genes causing ataxia. PMID: 22527681
    4. Rubicon may thus be pivotal to generating an optimal intracellular immune response against microbial infection. PMID: 22423966
    5. Rubicon differentially targets signaling complexes, depending on environmental stimuli, and may function to coordinate various immune responses against microbial infection. PMID: 22423967
    6. Rubicon and PLEKHM1 specifically and directly interact with Rab7 via their RH domain; this interaction is critical for their function; show Rubicon but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 and PI3-kinase PMID: 20943950
    7. a critical role of the Rubicon RUN domain in PI3KC3 and autophagy regulation PMID: 21062745
    8. we report the identification of a family with three children affected with a new form of recessive ataxia, which we suggest naming 'Salih ataxia', and of a frameshift mutation of KIAA0226 (rundataxin) that segregates with the disease PMID: 20826435

    顯示更多

    收起更多

  • 相關疾病:
    Spinocerebellar ataxia, autosomal recessive, 15 (SCAR15)
  • 亞細胞定位:
    Late endosome. Lysosome. Early endosome. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
  • 數據庫鏈接:

    HGNC: 28991

    OMIM: 613516

    KEGG: hsa:9711

    STRING: 9606.ENSP00000296343

    UniGene: Hs.478868



主站蜘蛛池模板: 新区乱码无人区二精东 | 日本一卡二卡四卡无卡国产| 欧美午夜一区二区福利视频| 久久久午夜精品福利内容| 欧美国产日韩a在线视频| 加勒比无码人妻东京热| 日韩爆乳一区二区无码| 国产成人夜色高潮福利影视| 国产重口老太和小伙| 在线精品国产成人综合| 最新亚洲春色av无码专区| 狼人大香伊蕉国产www亚洲| 又湿又黄裸乳漫画无遮挡网站| 一边摸一边叫床一边爽av| 亚洲中久无码永久在线观看同| 久久国产色av免费看| 醉酒后少妇被疯狂内射视频| 不卡av中文字幕手机看| 亚洲国产成人第一天堂| 狠狠噜天天噜日日噜| 国产99在线 | 中文| 欧美人成视频在线视频| 久久精品人妻中文系列| 久久精品无码中文字幕| 国精品午夜福利视频不卡 | 五月婷婷久久草| 国产情侣一区二区| 精品无码国产av一区二区| 国产精品国产三级欧美二区| 成人夜色视频网站在线观看| 亚洲熟女综合色一区二区三区 | 国产精品无码a∨果冻传媒| 伊人色综合一区二区三区影院视频| 亚洲色成人网站www永久| 99国产精品自在自在久久| 高清国产一区二区三区在线| 久久精品国产久精国产爱| 国产丰满老熟妇乱xxx1区| 无码精品国产一区二区三区免费| 在教室伦流澡到高潮hgl动漫 | 女人被强╳到高潮喷水在线观看|