在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RUBCN Antibody

RUBCN Antibody

  • 中文名稱：
    RUBCN兔多克隆抗體
  • 貨號：
    CSB-PA856415LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA856415LA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RUBCN Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Baron antibody; Beclin 1 associated RUN domain containing protein antibody; Beclin-1 associated RUN domain containing protein antibody; hypothetical protein LOC9711 antibody; Kiaa0226 antibody; OTTHUMP00000208021 antibody; OTTHUMP00000208023 antibody; OTTHUMP00000208024 antibody; RUBIC_HUMAN antibody; Rubicon antibody; RUN domain and cysteine rich domain containing, Beclin 1 interacting protein antibody; Run domain Beclin 1 interacting and cystein rich containing protein antibody; Run domain Beclin-1 interacting and cysteine-rich containing protein antibody; RUN domain protein as Beclin 1 interacting and cysteine rich containing antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (518-733AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，RUBCN Antibody (CSB-PA856415LA01HU)，的標記方式是Non-conjugated。對于RUBCN Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA856415LB01HU RUBCN Antibody, HRP conjugated ELISA
    FITC CSB-PA856415LC01HU RUBCN Antibody, FITC conjugated
    Biotin CSB-PA856415LD01HU RUBCN Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation.; Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines. Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or DDX58/RIG-I-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes.
  • 基因功能參考文獻：
    1. Rubicon thus functions as an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion. PMID: 28392573
    2. This study demonistrated that KIAA0226 mutation impairs Rubicon endosomal localization PMID: 23728897
    3. New DNA sequencing technologies are enabling us to investigate the whole or large targeted proportions of the genome in a rapid, affordable, and comprehensive way. Exome and targeted sequencing rundataxin genes causing ataxia. PMID: 22527681
    4. Rubicon may thus be pivotal to generating an optimal intracellular immune response against microbial infection. PMID: 22423966
    5. Rubicon differentially targets signaling complexes, depending on environmental stimuli, and may function to coordinate various immune responses against microbial infection. PMID: 22423967
    6. Rubicon and PLEKHM1 specifically and directly interact with Rab7 via their RH domain; this interaction is critical for their function; show Rubicon but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 and PI3-kinase PMID: 20943950
    7. a critical role of the Rubicon RUN domain in PI3KC3 and autophagy regulation PMID: 21062745
    8. we report the identification of a family with three children affected with a new form of recessive ataxia, which we suggest naming 'Salih ataxia', and of a frameshift mutation of KIAA0226 (rundataxin) that segregates with the disease PMID: 20826435

    顯示更多

    收起更多

  • 相關疾病：
    Spinocerebellar ataxia, autosomal recessive, 15 (SCAR15)
  • 亞細胞定位：
    Late endosome. Lysosome. Early endosome. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
  • 數據庫鏈接：

    HGNC: 28991

    OMIM: 613516

    KEGG: hsa:9711

    STRING: 9606.ENSP00000296343

    UniGene: Hs.478868



主站蜘蛛池模板： 亚洲欧美综合精品二区| 日韩人妻熟女中文字幕aⅴ春菜| 久久人妻无码中文字幕| 华人在线亚洲欧美精品| 国产成人精品a∨一区二区| 97色精品视频在线观看| 人妻少妇久久久久久97人妻| 久久精品99久久香蕉国产色戒| 99蜜桃臀久久久欧美精品网站 | 久国产精品人妻aⅴ| 极品粉嫩福利午夜在线播放 | 国产精品福利一区二区久久| 小罗莉极品一线天在线| 99久久国产热无码精品免费| 亚洲aⅴ无码国精品中文字慕| 天码欧美日本一道免费| 破了亲妺妺的处免费视频国产| 日本被黑人强伦姧人妻完整版| 国产猛男猛女超爽免费视频| 日韩人妻无码精品系列| 狠狠色丁香久久婷婷综合蜜芽五月 | 无码成人一区二区三区| 狼色精品人妻在线视频免费| 亚洲 欧洲 日韩 综合色天使| 狠狠躁天天躁无码中文字幕| 福利一区二区三区视频在线观看| 男女性杂交内射妇女bbwxz| 色8激情欧美成人久久综合电影| 国产精品美女久久久m| 午夜dj在线观看高清在线视频完整版| 免费久久99精品国产自在现线| 伊人成年网站综合网| 午夜爱爱免费视频体验区| 欧美xxxx做受欧美人妖| 日韩欧美猛交xxxxx无码| 亚洲动漫精品无码av天堂| 亚洲女人色综合小说| 国产精品美女久久久久av超清 | 欧美性大战久久久久久久| 色欲色香天天天综合网站| 男女下面一进一出无遮挡|