在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RUBCN Antibody, HRP conjugated

RUBCN Antibody, HRP conjugated

  • 中文名稱：
    RUBCN兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA856415LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RUBCN Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Baron antibody; Beclin 1 associated RUN domain containing protein antibody; Beclin-1 associated RUN domain containing protein antibody; hypothetical protein LOC9711 antibody; Kiaa0226 antibody; OTTHUMP00000208021 antibody; OTTHUMP00000208023 antibody; OTTHUMP00000208024 antibody; RUBIC_HUMAN antibody; Rubicon antibody; RUN domain and cysteine rich domain containing, Beclin 1 interacting protein antibody; Run domain Beclin 1 interacting and cystein rich containing protein antibody; Run domain Beclin-1 interacting and cysteine-rich containing protein antibody; RUN domain protein as Beclin 1 interacting and cysteine rich containing antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (518-733AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation.; Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines. Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or DDX58/RIG-I-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes.
  • 基因功能參考文獻(xiàn)：
    1. Rubicon thus functions as an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion. PMID: 28392573
    2. This study demonistrated that KIAA0226 mutation impairs Rubicon endosomal localization PMID: 23728897
    3. New DNA sequencing technologies are enabling us to investigate the whole or large targeted proportions of the genome in a rapid, affordable, and comprehensive way. Exome and targeted sequencing rundataxin genes causing ataxia. PMID: 22527681
    4. Rubicon may thus be pivotal to generating an optimal intracellular immune response against microbial infection. PMID: 22423966
    5. Rubicon differentially targets signaling complexes, depending on environmental stimuli, and may function to coordinate various immune responses against microbial infection. PMID: 22423967
    6. Rubicon and PLEKHM1 specifically and directly interact with Rab7 via their RH domain; this interaction is critical for their function; show Rubicon but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 and PI3-kinase PMID: 20943950
    7. a critical role of the Rubicon RUN domain in PI3KC3 and autophagy regulation PMID: 21062745
    8. we report the identification of a family with three children affected with a new form of recessive ataxia, which we suggest naming 'Salih ataxia', and of a frameshift mutation of KIAA0226 (rundataxin) that segregates with the disease PMID: 20826435

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Spinocerebellar ataxia, autosomal recessive, 15 (SCAR15)
  • 亞細(xì)胞定位：
    Late endosome. Lysosome. Early endosome. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28991

    OMIM: 613516

    KEGG: hsa:9711

    STRING: 9606.ENSP00000296343

    UniGene: Hs.478868



主站蜘蛛池模板： 人妻丰满熟妇av无码区| 黄网站成人片免费视频| 国产精品a久久777777| 久久久久国产精品人妻aⅴ果冻| 乱人伦人妻中文字幕无码| 亚洲国产成人片在线观看无码| 美女人妻激情乱人伦| 中文字幕欧美亚州视频免费| 中国产xxxxa片在线观看| 精品久久久久久久久中文字幕| 成人美女黄网站色大色费全看| 亚洲国产成人无码精品| 中国女人做爰视频| 99re6热在线精品视频观看| 国产av影片麻豆精品传媒| 在线a亚洲v天堂网2018| 色综合久久一区二区三区| 中文字幕无线码一区二区| 天天躁日日躁狠狠久久| 久久精品成人免费观看97| 97丨九色丨国产人妻熟女| 日日碰狠狠添天天爽| 天堂а√在线官网| 国产精品天干天干在线综合| 国产无遮挡又黄又爽免费视频| 中文字幕人成乱码熟女免费| 在线观看片免费人成视频播放| 国产成人年无码av片在线观看| 男女啪啪免费体验区| 国产精品久久毛片av大全日韩| 欧美极品video粗暴| 久久天天躁狠狠躁夜夜2020老熟妇| 玩超薄丝袜人妻的经历| 少妇人妻综合久久中文字幕| 日韩av第一页在线播放| 色欲av亚洲一区无码少妇| 人人妻人人澡人人爽人人dvd| 永久免费男同av无码入口| 又粗又黄又爽视频免费看| 国产成人精品123区免费视频| 成人做爰100部片免费下载|