在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Ribosomal RNA-processing protein 8 (RRP8)

Recombinant Human Ribosomal RNA-processing protein 8 (RRP8)

  • 中文名稱：
    人RRP8重組蛋白
  • 貨號：
    CSB-YP020531HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RRP8重組蛋白
  • 貨號：
    CSB-EP020531HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RRP8重組蛋白
  • 貨號：
    CSB-EP020531HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RRP8重組蛋白
  • 貨號：
    CSB-BP020531HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RRP8重組蛋白
  • 貨號：
    CSB-MP020531HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RRP8
  • Uniprot No.：
  • 別名：
    Cerebral protein 1; hypothetical protein LOC23378; KIAA0409; NML; Nucleomethylin; Ribosomal RNA processing 8 methyltransferase homolog; Ribosomal RNA processing 8, methyltransferase, homolog (yeast); Ribosomal RNA processing protein 8; Ribosomal RNA-processing protein 8; RRP 8; RRP8; RRP8 methyltransferase homolog; RRP8_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-456
  • 氨基酸序列
    MFEEPEWAEA APVAAGLGPV ISRPPPAASS QNKGSKRRQL LATLRALEAA SLSQHPPSLC ISDSEEEEEE RKKKCPKKAS FASASAEVGK KGKKKCQKQG PPCSDSEEEV ERKKKCHKQA LVGSDSAEDE KRKRKCQKHA PINSAQHLDN VDQTGPKAWK GSTTNDPPKQ SPGSTSPKPP HTLSRKQWRN RQKNKRRCKN KFQPPQVPDQ APAEAPTEKT EVSPVPRTDS HEARAGALRA RMAQRLDGAR FRYLNEQLYS GPSSAAQRLF QEDPEAFLLY HRGFQSQVKK WPLQPVDRIA RDLRQRPASL VVADFGCGDC RLASSIRNPV HCFDLASLDP RVTVCDMAQV PLEDESVDVA VFCLSLMGTN IRDFLEEANR VLKPGGLLKV AEVSSRFEDV RTFLRAVTKL GFKIVSKDLT NSHFFLFDFQ KTGPPLVGPK AQLSGLQLQP CLYKRR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
  • 基因功能參考文獻：
    1. NML depletion increases 60S ribosomal protein L11 (RPL11) levels in the ribosome-free fraction and protein levels of p53 through an RPL11-MDM2 complex, which activates the p53 pathway. PMID: 27149924
    2. Breast tumors without detectable nucleolar NML expression had poor survival. PMID: 26505814
    3. Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively. PMID: 26098692
    4. Data indicate that the the nucleomethylin (NML)-SirT1 interaction was competitively inhibited by rRNA. PMID: 23897426
    5. These observations suggest that NML may regulate consumption of hepatic triglyceride in liver regeneration after partial hepatectomy due to storage of excess ATP. PMID: 19819226

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, nucleolus. Note=Localizes at rDNA locus.
  • 蛋白家族：
    Methyltransferase superfamily, RRP8 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29030

    OMIM: 615818

    KEGG: hsa:23378

    STRING: 9606.ENSP00000254605

    UniGene: Hs.652255



主站蜘蛛池模板： 无码色偷偷亚洲国内自拍| 伊人久久大香线蕉综合影院首页| 久久国产色欲av38| 人成午夜免费大片| 亚洲国产精品一区二区成人片国内| 国产亚洲精品久久久久蜜臀| 一 级做人爱全视频在线看 | 精品国产乱码久久久久乱码| 变态另类牲交乱| 一区二区三区在线 | 日| 蜜臀av性久久久久蜜臀aⅴ| 欧美丰满熟妇xx猛交| 伊人狠狠色丁香婷婷综合| 免费人成视频在线观看不卡| 日本欧美亚洲中文在线观看| 久久aⅴ人妻少妇嫩草影院| 欧美黑人疯狂性受xxxxx喷水| 天干天干天啪啪夜爽爽99| 麻豆国产在线精品国偷产拍| 草裙社区精品视频三区免费看 | 亚洲精品久久婷婷丁香51| 一个人看的www免费视频在线观看| 丰满多毛的大隂户毛茸茸| 日本熟妇人妻videos| 亚洲精品无码鲁网中文电影| 国产精品99无码一区二区| 中文无码一区二区不卡av| 亚洲影院天堂中文av色| 国内精品久久久久久影院8f| 久久综合伊人| 国产一区二区女内射| 天天躁日日躁狠狠躁2018| 美女mm131午夜福利在线| 强行从后面挺进人妻| 夜夜高潮夜夜爽国产伦精品| 少妇性l交大片7724com| 精品午夜国产福利观看| 精品一卡2卡三卡4卡免费网站| 美女张开腿黄网站免费| 久久国产热精品波多野结衣av| 国产女人喷潮视频在线观看|