在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RRP8 Antibody

RRP8 Antibody

  • 中文名稱：
    RRP8兔多克隆抗體
  • 貨號：
    CSB-PA249711
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from MCF-7 cells, using HUCE1 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RRP8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RRP8
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human HUCE1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
  • 基因功能參考文獻：
    1. NML depletion increases 60S ribosomal protein L11 (RPL11) levels in the ribosome-free fraction and protein levels of p53 through an RPL11-MDM2 complex, which activates the p53 pathway. PMID: 27149924
    2. Breast tumors without detectable nucleolar NML expression had poor survival. PMID: 26505814
    3. Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively. PMID: 26098692
    4. Data indicate that the the nucleomethylin (NML)-SirT1 interaction was competitively inhibited by rRNA. PMID: 23897426
    5. These observations suggest that NML may regulate consumption of hepatic triglyceride in liver regeneration after partial hepatectomy due to storage of excess ATP. PMID: 19819226

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, nucleolus. Note=Localizes at rDNA locus.
  • 蛋白家族：
    Methyltransferase superfamily, RRP8 family
  • 數據庫鏈接：

    HGNC: 29030

    OMIM: 615818

    KEGG: hsa:23378

    STRING: 9606.ENSP00000254605

    UniGene: Hs.652255



主站蜘蛛池模板： 久久精品一区二区三区av| 人妻少妇无码精品专区| 欧美 日韩 国产 另类 图片区 | 强迫大乳人妻中文字幕| 日本视频免费高清一本18| 天堂最新版在线www官网中文地址| 亚洲夂夂婷婷色拍ww47| 欧美丰满一区二区免费视频| av蓝导航精品导航| 无码丰满熟妇bbbbxxx| 日本熟妇浓毛hdsex| 天天操夜夜操| 东京热加勒比视频一区| 亚洲成aⅴ人片在线观| 欧美无遮挡很黄裸交视频| 亚洲人成无码网站久久99热国产| 特级无码毛片免费视频播放▽| 亚洲精品乱码久久久久久日本麻豆| 国产末成年女av片一区二区| 国产品无码一区二区三区在线 | 日韩av爽爽爽久久久久久| 国产成人av大片在线播放| 久久久久成人精品无码| 亚洲国产欧美在线成人| 9999国产精品欧美久久久久久| 无码加勒比一区二区三区四区| 美女视频黄是免费| 男人女人午夜视频免费| 中文字幕久精品免费视频| 性色香蕉av久久久天天网| 亚洲 欧美 日韩 综合aⅴ| 国产精品无码日韩欧| 亚洲精品精华液一区二区| 午夜福利电影| 99久久久无码国产精品试看| 国产欧美日韩视频一区二区三区 | 人妻少妇中文字幕久久| 国产乱子伦精品免费无码专区| 成人一在线视频日韩国产| 国产深夜男女无套内射| 伦人伦xxx国产对白|