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  4. RRP8 Antibody

RRP8 Antibody

  • 中文名稱：
    RRP8兔多克隆抗體
  • 貨號：
    CSB-PA249711
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from MCF-7 cells, using HUCE1 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RRP8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RRP8
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human HUCE1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
  • 基因功能參考文獻：
    1. NML depletion increases 60S ribosomal protein L11 (RPL11) levels in the ribosome-free fraction and protein levels of p53 through an RPL11-MDM2 complex, which activates the p53 pathway. PMID: 27149924
    2. Breast tumors without detectable nucleolar NML expression had poor survival. PMID: 26505814
    3. Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively. PMID: 26098692
    4. Data indicate that the the nucleomethylin (NML)-SirT1 interaction was competitively inhibited by rRNA. PMID: 23897426
    5. These observations suggest that NML may regulate consumption of hepatic triglyceride in liver regeneration after partial hepatectomy due to storage of excess ATP. PMID: 19819226

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  • 亞細胞定位：
    Nucleus, nucleolus. Note=Localizes at rDNA locus.
  • 蛋白家族：
    Methyltransferase superfamily, RRP8 family
  • 數據庫鏈接：

    HGNC: 29030

    OMIM: 615818

    KEGG: hsa:23378

    STRING: 9606.ENSP00000254605

    UniGene: Hs.652255



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