在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Ribonuclease H1 (RNASEH1)

Recombinant Human Ribonuclease H1 (RNASEH1)

  • 中文名稱：
    人RNASEH1重組蛋白
  • 貨號(hào)：
    CSB-YP019801HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    人RNASEH1重組蛋白
  • 貨號(hào)：
    CSB-EP019801HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RNASEH1重組蛋白
  • 貨號(hào)：
    CSB-BP019801HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RNASEH1重組蛋白
  • 貨號(hào)：
    CSB-MP019801HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    RNASEH1; RNH1; Ribonuclease H1; RNase H1; EC 3.1.26.4; Ribonuclease H type II
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-286
  • 氨基酸序列
    MSWLLFLAHR VALAALPCRR GSRGFGMFYA VRRGRKTGVF LTWNECRAQV DRFPAARFKK FATEDEAWAF VRKSASPEVS EGHENQHGQE SEAKASKRLR EPLDGDGHES AEPYAKHMKP SVEPAPPVSR DTFSYMGDFV VVYTDGCCSS NGRRRPRAGI GVYWGPGHPL NVGIRLPGRQ TNQRAEIHAA CKAIEQAKTQ NINKLVLYTD SMFTINGITN WVQGWKKNGW KTSAGKEVIN KEDFVALERL TQGMDIQWMH VPGHSGFIGN EEADRLAREG AKQSED
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II.
  • 基因功能參考文獻(xiàn)：
    1. RNASEH1 gene variants associate with susceptibility/protection to T1 Diabetes in Colombia. PMID: 29204916
    2. Studies indicate that ribonuclease H1 is essential for mitochondrial DNA replication. PMID: 27402764
    3. Data show that the catalytic domains of E. coli and human RNase H have nearly identical sequence preferences, which correlate with the efficiency of RNase H-recruiting antisense oligonucleotides. PMID: 29126318
    4. Data suggest that ribonuclease H1 (RNASEH1) plays important role in replication fork movement by resolving R-loops (RNA-DNA hybrids); RNASEH1 depletion results in accumulation of RNA-DNA hybrids, slowing of replication forks, and increased DNA damage; RNASEH1 appears to contribute to genome stability and preserves telomere integrity. PMID: 28717002
    5. RPA is a sensor of R loops and a regulator of RNaseH1, extending the versatile role of RPA in suppression of genomic instability. PMID: 28257700
    6. RNaseH1 maintains regulated levels of telomeric RNA-DNA hybrids at ALT telomeres to trigger homologous recombination without compromising telomere integrity too severely PMID: 25330849
    7. found that the 3' fragments of target pre-mRNA generated by ASO were almost completely degraded from their 5' ends by nuclear XRN2 after RNase H1-mediated cleavage PMID: 26159921
    8. Altered RNaseH1 has a reduced capability to remove the RNA from RNA-DNA hybrids leading to impaired mtDNA replication and adult-onset mitochondrial encephalomyopathy. PMID: 26094573
    9. RNase H1 and protein P32 are involved in mitochondrial pre-rRNA processing PMID: 23990920
    10. data implicate the H264 side chain in phosphodiester hydrolysis as well as in product release, and are consistent with a proposed model in which the RNAse H1 H264 side chain interacts with a divalent metal ion to support catalysis PMID: 23078533
    11. On the basis of its nuclear magnetic resonance (NMR) nucleic acid structure, a boranophosphonate-modified, fully R(P) BH(3) DNA/RNA hybrid is predicted not to be a substrate for RNase H1. PMID: 21443203
    12. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624
    13. The cysteine residues responsible for the redox-dependent activity of RNase H1 were determined by site-directed mutagenesis to involve Cys(147) and Cys(148), producing an inactive enzyme conformation by disulfide bond formation. PMID: 12473655
    14. Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate PMID: 14506260
    15. in human cells RNase H1 is responsible for most of the activity of DNA-like antisense drugs PMID: 14960586
    16. analysis of catalytic site of human RNase H1 for heteroduplex substrate catalysis PMID: 15205459
    17. method for enhancing the human RNase H1 activity of chimeric antisense oligonucleotides PMID: 17028157
    18. THE role substrate structure plays in directing human RNase H1 activity as well as the design of effective antisense oligodeoxyribonucleotides. PMID: 17028158
    19. Report crystal structures of RNase H1 in complex with RNA/DNA hybrids. PMID: 17964265
    20. Characterization of full-length enzymes with defective hybrid binding domain indicates that this domain dramatically enhances both the specific activity and processivity of RNase H1. PMID: 18337749

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2 (PEOB2)
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    RNase H family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18466

    OMIM: 604123

    KEGG: hsa:246243

    STRING: 9606.ENSP00000313350

    UniGene: Hs.568006



主站蜘蛛池模板： 国产在线视频精品视频| 精品无码乱码av| 四虎精品免费永久免费视频| 久久丫精品忘忧草西安产品| 久久精品国产99国产精品导航 | 四虎国产精亚洲一区久久特色| 国产精品人妻久久毛片高清无卡 | 日韩好精品视频你懂的| 国产午夜福利在线观看视频 | 国产亚洲精品一区二三区| 国产精品丰臀| 尤物av无码色av无码| 国产手机在线亚洲精品观看| 日本成a人片在线播放| 四川丰满少妇被弄到高潮| 人人妻人人澡人人爽欧美一区| 狠狠综合亚洲综合亚洲色| a狠狠久久蜜臀婷色中文网 | 国产一区二区三区自产| 亚洲精品无码不卡在线播放| 猫咪www免费人成人入口| 天干夜啦天干天干国产免费| 黑人巨大videos精品| 在线播放亚洲人成电影| 无码成人精品区在线观看| 装睡被陌生人摸出水好爽| 日韩高清成片免费视频| 免费床视频大全叫不停欧美| 天天躁日日躁狠狠躁欧美老妇小说| 国产免国产免费| 婷婷五月深爱综合开心网| 欧美自拍亚洲综合图区| 国产精品自产拍高潮在线观看| 女人被黑人躁得好爽视频| 久久久女人与动物群交毛片| 文中字幕一区二区三区视频播放| 国产无遮挡无码视频免费软件| 秋霞av在线露丝片av无码| 亚洲精品网站在线观看你懂的| 国产成人无码www免费视频播放| 国产亚洲视频在线播放香蕉|