在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Rho guanine nucleotide exchange factor 5 (ARHGEF5), partial

Recombinant Human Rho guanine nucleotide exchange factor 5 (ARHGEF5), partial

  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 5(ARHGEF5) ,partial
  • 貨號(hào)：
    CSB-YP618628HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 5(ARHGEF5) ,partial
  • 貨號(hào)：
    CSB-EP618628HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 5(ARHGEF5) ,partial
  • 貨號(hào)：
    CSB-EP618628HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 5(ARHGEF5) ,partial
  • 貨號(hào)：
    CSB-BP618628HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 5(ARHGEF5) ,partial
  • 貨號(hào)：
    CSB-MP618628HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ARHGEF5
  • Uniprot No.：
  • 別名：
    ARHG5_HUMAN; ARHGEF 5; ARHGEF5; DKFZp686N1969; ephexin 3; Ephexin-3; GEF 5; GEF5; Guanine nucleotide regulatory protein TIM; Oncogene TIM; P60; p60 TIM; Rho guanine nucleotide exchange factor (GEF) 5; Rho guanine nucleotide exchange factor 5; TIM 1; TIM; TIM1; Transforming immortalized mammary oncogene
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Involved in positive regulation of immature dendritic cell migration.
  • 基因功能參考文獻(xiàn)：
    1. Tim protein and DDX11 physically and functionally interact and act in concert to preserve replication fork progression in perturbed conditions. PMID: 26503245
    2. Data indicate that Rho guanine nucleotide exchange factor 5 (ARHGEF5) is expressed in most human lung adenocarcinoma tissues and cell lines. PMID: 25777963
    3. Targeting rho guanine nucleotide exchange factor ARHGEF5/TIM with auto-inhibitory peptides in human breast cancer. PMID: 25743165
    4. The auto-inhibitory state of Rho guanine nucleotide exchange factor ARHGEF5/TIM can be relieved by targeting its SH3 domain with rationally designed peptide aptamers. PMID: 25645980
    5. In conclusion, ARHGEF5/Src can be considered as a prognostic biomarker and a therapeutic target for patients with resected NSCLC. PMID: 24126923
    6. A receiver operating characteristic curve constructed with HSP105 and TIM gave a sensitivity of 54.3% and 95% (38/40) specificity in discriminating esophageal squamous cell carcinoma from matched controls. PMID: 24157810
    7. This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans. PMID: 23647072
    8. Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins. PMID: 23359676
    9. Overexpression of Arhgef5 promoted actin stress fiber remodeling through activating RhoA, and the activation of RhoA or Cdc42 was required for Src-induced podosome formation. PMID: 21525037
    10. association in humans of TIM-1 and hypersensitivity and the relationship between TIM1, hygiene, and the environment. PMID: 15681748
    11. The expression level of TIM was decreased in hepatocellular carcinoma. PMID: 18444243
    12. RhoA guanine nucleotide exchange factor Arhgef5 regulates immature dendritic cell migration PMID: 19713215

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Cell projection, podosome.
  • 組織特異性：
    Ubiquitously expressed with highest levels in placenta. High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland. In fetal tissues, expressed at high levels in kidney, lung and liver
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13209

    OMIM: 600888

    KEGG: hsa:7984

    STRING: 9606.ENSP00000056217

    UniGene: Hs.334



主站蜘蛛池模板： 午夜dy888国产精品影院| 欧美日韩国产精品自在自线| 国产成人精品综合久久久久| 污污又黄又爽免费的网站| 国产丰满麻豆vⅰde0sex| 中国猛少妇色xxxxx| 一本大道伊人av久久乱码| 人妻少妇精品无码专区二区| 337p人体 欧洲人体 亚洲| 成年入口无限观看免费完整大片| 婷婷五月小说| 欧美粗大猛烈老熟妇| 国厂精品114福利电影免费| 日本一卡2卡3卡4卡免费乱码网站| 久久久久99精品成人片| 99热精品久久只有精品| 无码人妻丰满熟妇区免费| 影音先锋日日狠狠久久| 综合图区亚洲欧美另类图片| 艳z门照片无码av| 在线看片无码永久免费视频| 亚洲成成品网站源码中国有限公司 | 首页 综合国产 亚洲 丝袜| 被窝影院午夜无码国产| 久久精品噜噜噜成人av| 久久久久人妻精品一区蜜桃 | 少妇人妻丰满做爰xxx| 少妇把腿扒开让我爽爽视频| 五月婷婷之综合缴情| 亚洲高清国产拍精品26u| 在线视频观看免费视频18| 色先锋av影音先锋在线| 欧美肥胖老太vidio在线视频| 好爽...又高潮了毛片| 亲嘴扒胸摸屁股激烈网站| 国产做无码视频在线观看浪潮| 欧美变态另类牲交| 欧美天天综合色影久久精品| 亚洲成av人片一区二区密柚| 免费无人区男男码卡二卡| 久久99精品久久久久久蜜芽 |