在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ARHGEF5 Antibody

ARHGEF5 Antibody

  • 中文名稱：
    ARHGEF5兔多克隆抗體
  • 貨號：
    CSB-PA160272
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA160272(ARHGEF5 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA160272(ARHGEF5 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ARHGEF5
  • 別名：
    ARHG5_HUMAN antibody; ARHGEF 5 antibody; ARHGEF5 antibody; DKFZp686N1969 antibody; ephexin 3 antibody; Ephexin-3 antibody; GEF 5 antibody; GEF5 antibody; Guanine nucleotide regulatory protein TIM antibody; Oncogene TIM antibody; P60 antibody; p60 TIM antibody; Rho guanine nucleotide exchange factor (GEF) 5 antibody; Rho guanine nucleotide exchange factor 5 antibody; TIM 1 antibody; TIM antibody; TIM1 antibody; Transforming immortalized mammary oncogene antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Fusion protein of Human ARHGEF5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Involved in positive regulation of immature dendritic cell migration.
  • 基因功能參考文獻：
    1. Tim protein and DDX11 physically and functionally interact and act in concert to preserve replication fork progression in perturbed conditions. PMID: 26503245
    2. Data indicate that Rho guanine nucleotide exchange factor 5 (ARHGEF5) is expressed in most human lung adenocarcinoma tissues and cell lines. PMID: 25777963
    3. Targeting rho guanine nucleotide exchange factor ARHGEF5/TIM with auto-inhibitory peptides in human breast cancer. PMID: 25743165
    4. The auto-inhibitory state of Rho guanine nucleotide exchange factor ARHGEF5/TIM can be relieved by targeting its SH3 domain with rationally designed peptide aptamers. PMID: 25645980
    5. In conclusion, ARHGEF5/Src can be considered as a prognostic biomarker and a therapeutic target for patients with resected NSCLC. PMID: 24126923
    6. A receiver operating characteristic curve constructed with HSP105 and TIM gave a sensitivity of 54.3% and 95% (38/40) specificity in discriminating esophageal squamous cell carcinoma from matched controls. PMID: 24157810
    7. This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans. PMID: 23647072
    8. Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins. PMID: 23359676
    9. Overexpression of Arhgef5 promoted actin stress fiber remodeling through activating RhoA, and the activation of RhoA or Cdc42 was required for Src-induced podosome formation. PMID: 21525037
    10. association in humans of TIM-1 and hypersensitivity and the relationship between TIM1, hygiene, and the environment. PMID: 15681748
    11. The expression level of TIM was decreased in hepatocellular carcinoma. PMID: 18444243
    12. RhoA guanine nucleotide exchange factor Arhgef5 regulates immature dendritic cell migration PMID: 19713215

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Cell projection, podosome.
  • 組織特異性：
    Ubiquitously expressed with highest levels in placenta. High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland. In fetal tissues, expressed at high levels in kidney, lung and liver
  • 數據庫鏈接：

    HGNC: 13209

    OMIM: 600888

    KEGG: hsa:7984

    STRING: 9606.ENSP00000056217

    UniGene: Hs.334



主站蜘蛛池模板： av一区二区国产在线视频| 最新欧美精品一区二区三区| 大又大又粗又硬又爽少妇毛片| 亚洲精品无码一区二区| 亚洲乱码精品久久久久.. | 日韩免费人妻av无码专区蜜桃| 99r在线精品视频在线播放| 9lporm自拍视频区| 国产乱妇无码大片在线观看 | 免费午夜爽爽爽www视频十八禁| 国产精品无码av无码| 激情综合色五月六月婷婷| 日日日日做夜夜夜夜做无码| 国产成人精品免费午夜app| 午夜福利三级理论电影| 亚洲色偷偷色噜噜狠狠99网| 国产精品高潮呻吟av久久无吗| 夜夜精品无码一区二区三区| 免费无码成人av片在线| 男人边吃奶边揉好爽免费视频| 国产黑色丝袜在线视频| 国产精品亚洲专区无码不卡| 亚洲国产一卡2卡3卡4卡5公司 | 亚洲综合色区中文字幕| 综合无码一区二区三区| 欧洲熟妇色xxxx欧美老妇老头多毛| 老湿机国产福利视频| 亚洲国产精品无码久久| 欧美黑人xxxx高潮猛交| 超清中文乱码字幕在线观看| 国产精品亚洲片在线观看不卡| 中文字幕av一区乱码| 欧美人成精品网站播放| 67194成是人免费无码| 亚洲中文字幕乱码电影| 日韩无套内射高潮| 亚洲人ⅴsaⅴ国产精品| 欧美激情一区二区三区高清视频| 亚洲中文字幕码在线电影| 久久99er精品国产首页| 精品国产乱码久久久久久口爆|