在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Rho guanine nucleotide exchange factor 26 (ARHGEF26), partial

Recombinant Human Rho guanine nucleotide exchange factor 26 (ARHGEF26), partial

  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 26(ARHGEF26) ,partial
  • 貨號：
    CSB-YP850280HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 26(ARHGEF26) ,partial
  • 貨號：
    CSB-EP850280HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 26(ARHGEF26) ,partial
  • 貨號：
    CSB-EP850280HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 26(ARHGEF26) ,partial
  • 貨號：
    CSB-BP850280HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 26(ARHGEF26) ,partial
  • 貨號：
    CSB-MP850280HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ARHGEF26
  • Uniprot No.：
  • 別名：
    ARHGEF26; SGEF; HMFN1864; Rho guanine nucleotide exchange factor 26; SH3 domain-containing guanine exchange factor
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
  • 基因功能參考文獻：
    1. SGEF plays a role in activating RhoG during invadopodia disassembly PMID: 28202690
    2. High SGEF expression is associated with lung adenocarcinoma. PMID: 29454349
    3. Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes. PMID: 28714974
    4. yrosine phosphorylation of SGEF suppresses its interaction with RhoG, the elevation of RhoG activity, and SGEF-mediated promotion of cell migration. We identified tyrosine 530 (Y530), which is located within the Dbl homology domain, as a major phosphorylation site of SGEF by Src, and Y530F mutation blocked the inhibitory effect of Src on SGEF PMID: 27437949
    5. Data support evidence for SGEF role in both the promotion of cell invasion and cell survival signaling within glioblastoma tumors and promoting chemotherapeutic resistance. PMID: 26764186
    6. A novel function of SGEF that excludes GEF. PMID: 24399467
    7. We report for the first time an SGEF function for RhoG that excludes GEF and the ability of SGEF to enhance EGFR stability and signaling by delaying its lysosomal sorting and degradation PMID: 23661635
    8. Data indicate that the Src homology 3 domain-containing GEF (SGEF) promotes fibroblast growth factor-inducible 14 (Fn14) proinvasive signaling in glioblastoma via TNF receptor-associated factor 2 (TRAF2). PMID: 23775076
    9. SGEF is a novel promoter of human prostate cancer progression and development. PMID: 22824926
    10. The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity. PMID: 22383878
    11. SGEF gene on chromosome 3q25.2. CSGEF expression controlled by androgen-responsive promoter of SGEF gene. SGEF may be regulator of Rho guanosine triphosphatases. CSGEF may function as regulator of Rho guanosine triphosphatase in prostate PMID: 12697679

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell projection, ruffle.
  • 組織特異性：
    Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.
  • 數據庫鏈接：

    HGNC: 24490

    OMIM: 617552

    KEGG: hsa:26084

    STRING: 9606.ENSP00000348828

    UniGene: Hs.240845



主站蜘蛛池模板： 又粗又黄又爽视频免费看| 欧美激情乱人伦| 自拍校园亚洲欧美另类| 午夜国产成人片在线播放| 巨大欧美黑人xxxxbbbb| 中文字幕乱码免费看电影| 四虎永久在线高清国产精品| 92国产精品午夜福利无毒不卡| 少妇性荡欲午夜性开放视频剧场| 国产乱子伦一区二区三区| 在线观看日本亚洲一区| 真人一进一出120秒试看| 久久精品香蕉绿巨人登场| 久久久99精品成人片中文字幕| 亚洲最大的成人网| 亚洲国产综合无码一区| 欧美精品黑人粗大破除| 亚洲精品久久久久avwww潮水| 无码137片内射在线影院| 国产成人无码av在线影院| 国产av成人无码精品网站| 久久天天躁狠狠躁夜夜2020一| 天堂а√在线中文在线新版| 亚洲 日韩 欧美 有码 在线| 国产曰批免费视频播放免费| 一本之道高清无码视频| 青青青国产精品国产精品美女| 国产69精品久久久久孕妇| 丰满少妇人妻无码专区| 国产内射合集颜射| 97性无码区免费| 精品人妻无码一区二区三区蜜桃一| 日本乱子人伦在线视频| 精品高朝久久久久9999| 国产亚洲精品欧洲在线观看 | 久久99av无色码人妻蜜| 999久久久国产精品| 久久国产36精品色熟妇| 狼友av永久网站免费观看孕交 | 日本少妇人妻xxxxx18| 国产精品无套呻吟在线|