在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Rho guanine nucleotide exchange factor 18 (ARHGEF18), partial

  • 中文名稱:
    Recombinant Human Rho guanine nucleotide exchange factor 18(ARHGEF18) ,partial
  • 貨號:
    CSB-YP744417HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Rho guanine nucleotide exchange factor 18(ARHGEF18) ,partial
  • 貨號:
    CSB-EP744417HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Rho guanine nucleotide exchange factor 18(ARHGEF18) ,partial
  • 貨號:
    CSB-BP744417HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Rho guanine nucleotide exchange factor 18(ARHGEF18) ,partial
  • 貨號:
    CSB-MP744417HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    ARHGEF18
  • Uniprot No.:
  • 別名:
    114 kDa Rho specific guanine nucleotide exchange factor; 114 kDa Rho-specific guanine nucleotide exchange factor; ARHGEF 18; Arhgef18; ARHGI_HUMAN; KIAA0521; MGC15913; p114 Rho GEF; p114-Rho-GEF; p114RhoGEF; Rho guanine nucleotide exchange factor 18; Rho specific guanine nucleotide exchange factor p114; Rho/Rac guanine nucleotide exchange factor (GEF) 18; Rho/Rac guanine nucleotide exchange factor 18; SA RhoGEF; SA-RhoGEF; Septin associated RhoGEF; Septin-associated RhoGEF
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells.
  • 基因功能參考文獻:
    1. mutation of ARHGEF18 is a likely cause of inherited retinal dystrophy PMID: 28132693
    2. CRB3A recruits p114RhoGEF and its activator Ehm2 to the cell periphery using both functional motifs of its cytoplasmic tail and increases RhoA activation levels. PMID: 26217016
    3. LKB1 and p114RhoGEF control RhoA activity in bronchial epithelial cells to promote apical junction assembly. PMID: 23648482
    4. Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion. PMID: 23185572
    5. In its regulation of the circumferential actomyosin tensile system, Lulu2 interacts with and activates p114RhoGEF at apical cell-cell junctions. PMID: 22006950
    6. Data indicate that p114RhoGEF is a component of a junction-associated Rho signalling module that drives spatially restricted activation of RhoA to regulate junction formation and epithelial morphogenesis. PMID: 21258369
    7. p114-RhoGEF and Lfc are critically involved in Wnt-3a- and Dvl-induced RhoA activation and neurite retraction in N1E-115 cells. PMID: 20810787
    8. data showed that the novel guanine nucleotide exchange factor p114RhoGEF regulates the activity of RhoA and Rac1, and that Gbetagamma subunits of heterotrimeric G proteins are activators of p114RhoGEF under physiological conditions PMID: 14512443

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Retinitis pigmentosa 78 (RP78)
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Apical cell membrane.
  • 組織特異性:
    Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Isoform 1: Expressed in eosinophils. Isoform 2: Expressed in eosinophils. Isoform 3: Expressed in eosinophils. Is
  • 數據庫鏈接:

    HGNC: 17090

    OMIM: 616432

    KEGG: hsa:23370

    STRING: 9606.ENSP00000352995

    UniGene: Hs.465761



主站蜘蛛池模板: 丰满熟女人妻中文字幕免费| 欧美性色黄大片| 女人被男人躁得好爽免费视频| 国产精品久久国产精品99| 国产成人a视频高清在线观看| 久久五月精品中文字幕| 日本亚洲色大成网站www| 97免费公开在线视频| 美乳丰满人妻无码视频| av无码国产在线观看岛国| 久久爱www人成狠狠爱综合网| 少妇无码精油按摩专区| 午夜三级a三级三点在线观看| 青青草视频免费观看| 亚洲免费观看在线视频| 国产熟妇搡bbbb搡bbbb搡| 国产成人综合久久三区| 国内外精品激情刺激在线| 亚洲午夜久久久无码精品网红a片| 国产小受呻吟gv视频在线观看| 午夜成人鲁丝片午夜精品| 欧美日韩在线第一页免费观看| 一边捏奶头一边啪高潮视频| 亚洲国产日韩在线人成蜜芽| 在线观看精品视频网站| 日产精品久久久久久久| av在线播放日韩亚洲欧| 99精品国产在热久久| 亚洲系列一区中文字幕| 特级毛片全部免费播放| 131mm少妇做爰视频| 国产白嫩美女在线观看| 人人妻人人做人人爽| 越猛烈欧美xx00动态图| 中国少妇大p毛茸茸| 好紧好湿好黄的视频| 亚洲 小说区 图片区 都市| 色猫咪av在线观看| 大香伊蕉在人线国产最新75| 欧美人与动牲交免费观看| 欧美老熟妇xb水多毛多|