在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ARHGEF18 Antibody, FITC conjugated

ARHGEF18 Antibody, FITC conjugated

  • 中文名稱：
    ARHGEF18兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA019681HC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ARHGEF18 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ARHGEF18
  • 別名：
    114 kDa Rho specific guanine nucleotide exchange factor antibody; 114 kDa Rho-specific guanine nucleotide exchange factor antibody; ARHGEF 18 antibody; Arhgef18 antibody; ARHGI_HUMAN antibody; KIAA0521 antibody; MGC15913 antibody; p114 Rho GEF antibody; p114-Rho-GEF antibody; p114RhoGEF antibody; Rho guanine nucleotide exchange factor 18 antibody; Rho specific guanine nucleotide exchange factor p114 antibody; Rho/Rac guanine nucleotide exchange factor (GEF) 18 antibody; Rho/Rac guanine nucleotide exchange factor 18 antibody; SA RhoGEF antibody; SA-RhoGEF antibody; Septin associated RhoGEF antibody; Septin-associated RhoGEF antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Rho guanine nucleotide exchange factor 18 protein (159-551AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells.
  • 基因功能參考文獻：
    1. mutation of ARHGEF18 is a likely cause of inherited retinal dystrophy PMID: 28132693
    2. CRB3A recruits p114RhoGEF and its activator Ehm2 to the cell periphery using both functional motifs of its cytoplasmic tail and increases RhoA activation levels. PMID: 26217016
    3. LKB1 and p114RhoGEF control RhoA activity in bronchial epithelial cells to promote apical junction assembly. PMID: 23648482
    4. Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion. PMID: 23185572
    5. In its regulation of the circumferential actomyosin tensile system, Lulu2 interacts with and activates p114RhoGEF at apical cell-cell junctions. PMID: 22006950
    6. Data indicate that p114RhoGEF is a component of a junction-associated Rho signalling module that drives spatially restricted activation of RhoA to regulate junction formation and epithelial morphogenesis. PMID: 21258369
    7. p114-RhoGEF and Lfc are critically involved in Wnt-3a- and Dvl-induced RhoA activation and neurite retraction in N1E-115 cells. PMID: 20810787
    8. data showed that the novel guanine nucleotide exchange factor p114RhoGEF regulates the activity of RhoA and Rac1, and that Gbetagamma subunits of heterotrimeric G proteins are activators of p114RhoGEF under physiological conditions PMID: 14512443

    顯示更多

    收起更多

  • 相關疾病：
    Retinitis pigmentosa 78 (RP78)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Apical cell membrane.
  • 組織特異性：
    Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Isoform 1: Expressed in eosinophils. Isoform 2: Expressed in eosinophils. Isoform 3: Expressed in eosinophils. Is
  • 數據庫鏈接：

    HGNC: 17090

    OMIM: 616432

    KEGG: hsa:23370

    STRING: 9606.ENSP00000352995

    UniGene: Hs.465761



主站蜘蛛池模板： 久久大香香蕉国产| 欧美最猛黑人xxxxx猛交| 精品午夜福利无人区乱码一区 | 精品国产乱码久久久久夜深人妻| 亚洲综合av色婷婷| 99999久久久久久亚洲| 在线观看无码av免费不卡软件| 人妻少妇精品视频二区| 少妇一夜三次一区二区| 97性无码区免费| 99久久国产综合精品五月天喷水| 国内精品免费网站牛牛| 一二三四在线视频社区3| 国产精品久久精品国产| 青青草国产久久精品| 久久www免费人成看片入口| 18禁免费无码无遮挡不卡网站| 久久久受www免费人成| 亚洲制服 视频在线观看| 99热成人精品热久久| 熟妇人妻va精品中文字幕| 成人做爰视频www网站小优视频| 亚洲欧洲自拍拍偷综合| 鲁鲁狠狠狠7777一区二区 | 午夜性色福利在线视频福利| 97久久精品人人槡人妻人| 在线a亚洲视频播放在线观看| 囯产精品一品二区三区| 美女扒开奶罩露出奶头视频网站 | 国产香蕉尹人在线视频你懂的| 国产综合有码无码中文字幕| 国产日产韩国精品视频| 99精品国产一区二区三区| 久久综合色一综合色88| 中文字幕久久精品无码| 国产中文字字幕乱码无限| 久久久亚洲精品无码| 亚洲精品无码av人在线观看国产| 久久av无码精品人妻糸列| 娇妻被黑人粗大高潮白浆| 天堂а√中文在线|