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  4. ARHGEF18 Antibody, Biotin conjugated

ARHGEF18 Antibody, Biotin conjugated

  • 中文名稱：
    ARHGEF18兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA019681HD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ARHGEF18 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ARHGEF18
  • 別名：
    114 kDa Rho specific guanine nucleotide exchange factor antibody; 114 kDa Rho-specific guanine nucleotide exchange factor antibody; ARHGEF 18 antibody; Arhgef18 antibody; ARHGI_HUMAN antibody; KIAA0521 antibody; MGC15913 antibody; p114 Rho GEF antibody; p114-Rho-GEF antibody; p114RhoGEF antibody; Rho guanine nucleotide exchange factor 18 antibody; Rho specific guanine nucleotide exchange factor p114 antibody; Rho/Rac guanine nucleotide exchange factor (GEF) 18 antibody; Rho/Rac guanine nucleotide exchange factor 18 antibody; SA RhoGEF antibody; SA-RhoGEF antibody; Septin associated RhoGEF antibody; Septin-associated RhoGEF antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Rho guanine nucleotide exchange factor 18 protein (159-551AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells.
  • 基因功能參考文獻：
    1. mutation of ARHGEF18 is a likely cause of inherited retinal dystrophy PMID: 28132693
    2. CRB3A recruits p114RhoGEF and its activator Ehm2 to the cell periphery using both functional motifs of its cytoplasmic tail and increases RhoA activation levels. PMID: 26217016
    3. LKB1 and p114RhoGEF control RhoA activity in bronchial epithelial cells to promote apical junction assembly. PMID: 23648482
    4. Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion. PMID: 23185572
    5. In its regulation of the circumferential actomyosin tensile system, Lulu2 interacts with and activates p114RhoGEF at apical cell-cell junctions. PMID: 22006950
    6. Data indicate that p114RhoGEF is a component of a junction-associated Rho signalling module that drives spatially restricted activation of RhoA to regulate junction formation and epithelial morphogenesis. PMID: 21258369
    7. p114-RhoGEF and Lfc are critically involved in Wnt-3a- and Dvl-induced RhoA activation and neurite retraction in N1E-115 cells. PMID: 20810787
    8. data showed that the novel guanine nucleotide exchange factor p114RhoGEF regulates the activity of RhoA and Rac1, and that Gbetagamma subunits of heterotrimeric G proteins are activators of p114RhoGEF under physiological conditions PMID: 14512443

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  • 相關疾病：
    Retinitis pigmentosa 78 (RP78)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Apical cell membrane.
  • 組織特異性：
    Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Isoform 1: Expressed in eosinophils. Isoform 2: Expressed in eosinophils. Isoform 3: Expressed in eosinophils. Is
  • 數據庫鏈接：

    HGNC: 17090

    OMIM: 616432

    KEGG: hsa:23370

    STRING: 9606.ENSP00000352995

    UniGene: Hs.465761



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