在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Rho guanine nucleotide exchange factor 1 (ARHGEF1), partial

Recombinant Human Rho guanine nucleotide exchange factor 1 (ARHGEF1), partial

  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 1(ARHGEF1) ,partial
  • 貨號：
    CSB-YP856434HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 1(ARHGEF1) ,partial
  • 貨號：
    CSB-EP856434HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 1(ARHGEF1) ,partial
  • 貨號：
    CSB-EP856434HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 1(ARHGEF1) ,partial
  • 貨號：
    CSB-BP856434HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 1(ARHGEF1) ,partial
  • 貨號：
    CSB-MP856434HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    115 kD protein; 115 kDa guanine nucleotide exchange factor; ARHG1_HUMAN; ARHGEF 1; ARHGEF1; GEF 1; GEF1; LBCL 2; LBCL2; LSC; Lsc homolog; p115 RhoGEF; p115-RhoGEF; p115RhoGEF; Rho guanine nucleotide exchange factor (GEF) 1; Rho guanine nucleotide exchange factor 1; Sub1.5
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
  • 基因功能參考文獻：
    1. Data suggest that MCP1/CCL2 induces activation/tyrosine phosphorylation of ARHGEF1/p115-RhoGEF and up-regulates RAC1 signaling in vascular smooth muscle cells (VSMCs); ARHGEF1 inhibition suppresses MCP1-induced VSMC migration and proliferation. (ARHGEF1 = Rho guanine nucleotide exchange factor 1; RAC1 = Rac family small GTPase 1; CCL2 = C-C motif chemokine ligand 2) PMID: 28655771
    2. Data indicate that the crystal structure of PDZ-RhoGEF PDZ domain in complex with the CXC chemokine receptor 2 (CXCR2) C-terminal PDZ binding motif. PMID: 28179147
    3. We have reported here for the first time a reduced activity of both Rac1 and Cdc42 in human pheochromocytoma resection as well as tumor-associated expression changes of FARP1, ARHGEF1, and ARHGAP36 PMID: 26911374
    4. contactin-1 displayed the ability to phosphorylate the RhoA activator p115 RhoGEF PMID: 25916117
    5. The novel role for p115RhoGEF in regulation of epithelial plasticity is dependent on Rho-DRF signaling module. PMID: 24465552
    6. Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs). PMID: 24855647
    7. Modification of p115RhoGEF at Serine(330) regulates its RhoGEF activity. PMID: 23816534
    8. The action of DOCK7 in vivo may involve the coordinated integration of Cdc42/Rac1 signaling in the context of the membrane recruitment of a DOCK7 guanine nucleotide exchange factor (GEF) complex. PMID: 23718289
    9. High GEF1 expression is associated with metastasis of pancreatic cancer. PMID: 23070684
    10. Activation of p115-RhoGEF requires direct association of Galpha13 and the Dbl homology domain. PMID: 22661716
    11. Upon beta(2)AR activation, both betaArrestin2 and p115RhoGEF translocate to the plasma membrane, with concomitant activation of RhoA and formation of focal adhesions and stress fibers. PMID: 22500016
    12. Thromboxane receptor signaling is required for fibronectin-induced matrix metalloproteinase 9 production by human and murine macrophages and is attenuated by the Arhgef1 molecule. PMID: 22086927
    13. Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG). PMID: 21454492
    14. The linker region connecting the N-terminal RGS-homology domain and the Dbl homology domain inhibits the intrinsic guanine nucleotide exchange activity of p115. PMID: 21064165
    15. ARHGEF1 is involed in hypertension by controlling its molecular mechanisms. PMID: 20619149
    16. coexpression of a dominant negative PDZ-RhoGEF abrogated the ability of plexin-B1 to cause stress fiber formation PMID: 12372594
    17. rgRGS domain may serve a structural or allosteric role in the regulation of the nucleotide exchange activity of p115RhoGEF on Rho by Galpha(13) PMID: 12525488
    18. CD44 interaction with p115RhoGEF and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3-kinase membrane localization, AKT signaling, and cytokine (M-CSF) production during HA-mediated breast cancer progression PMID: 12748184
    19. data demonstrate a pathway of Rho activation involving protein kinase c alpha-dependent phosphorylation of p115Rho guanine exchange factor PMID: 12754211
    20. Data show that different rho guanine nucleotide exchange factors (rhoGEFs; p115rhoGEF, LARG and PDZrhoGEF) mediate downstream rho signaling by the thrombin and lysophosphatidic acid receptors. PMID: 15143072
    21. Several features of a typical alpha/RGS interaction are preserved in the alpha(13)/p115RhoGEF interaction. PMID: 15735747
    22. analysis of a novel cross-talk exerted from the LPA/Galpha(13)/p115RhoGEF/RhoA pathway to the beta(2)-adrenergic receptor/Galpha(s)/adenylyl cyclase pathway PMID: 17493936
    23. A pronounced and rapid translocation of p115-RhoGEF from the cytosol to the plasma membrane was observed upon activation of several G(12/13)-coupled receptors in a cell type-independent fashion. PMID: 18320579
    24. Data show that microtubules in neighboring cells reorient and target p115 RhoGEF to sites where dying cells are squeezed out of the epithelial sheet. PMID: 19720875

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or LPA stimulation.
  • 組織特異性：
    Ubiquitously expressed.
  • 數據庫鏈接：

    HGNC: 681

    OMIM: 601855

    KEGG: hsa:9138

    STRING: 9606.ENSP00000337261

    UniGene: Hs.631550



主站蜘蛛池模板： 欧美日韩午夜群交多人轮换| 亚洲国产精品无码久久sm| 蜜臀av免费一区二区三区| 无码av无码天堂资源网| 猫咪www免费人成网站无码| 久久久久久久精品成人执小说一白| 老熟女老太婆爽| 国产精欧美一区二区三区| 1000部精品久久久久久久久| 日韩a毛片免费观看| 韩国和日本免费不卡在线v| 99久久人妻无码精品系列蜜桃| 人妻无码一区二区不卡无码av| 亚洲精品无码专区在线观看| 日本高清无卡码一区二区| 天天躁夜夜躁av天天爽| www国产精品内射老熟女| 国产成人免费无庶挡视频| 无人区一码卡二卡三乱码| 精品久久人人爽天天玩人人妻| 亚洲日韩在线中文字幕线路2区| 亚洲欧美综合精品成人导航 | 最新永久无码av网址亚洲| 超清精品丝袜国产自在线拍| 欧美精品国产综合久久| 亚洲色成人www永久网站| 一本一道中文字幕无码东京热| 久久www色情成人免费观看| 18禁裸体动漫美女无遮挡网站 | 久久综合九色综合欧洲98| 久久精品aⅴ无码中文字字幕蜜桃| 人妻教师痴汉电车波多野结衣| 成人av久久一区二区三区 | 免费看欧美成人a片无码| 精品国产午夜肉伦伦影院| 久久人妻xunleige无码| 国产精品免费久久久久影院仙踪林| 国产欧美日韩精品a在线观看| 亚洲美女国产精品久久久久久久久| 99精品国产一区二区三区不卡| 对白脏话肉麻粗话av|