在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ARHGEF1 Antibody

ARHGEF1 Antibody

  • 中文名稱：
    ARHGEF1兔多克隆抗體
  • 貨號：
    CSB-PA123263
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA123263(ARHGEF1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA123263(ARHGEF1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    115 kD protein antibody; 115 kDa guanine nucleotide exchange factor antibody; ARHG1_HUMAN antibody; ARHGEF 1 antibody; ARHGEF1 antibody; GEF 1 antibody; GEF1 antibody; LBCL 2 antibody; LBCL2 antibody; LSC antibody; Lsc homolog antibody; p115 RhoGEF antibody; p115-RhoGEF antibody; p115RhoGEF antibody; Rho guanine nucleotide exchange factor (GEF) 1 antibody; Rho guanine nucleotide exchange factor 1 antibody; Sub1.5 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ARHGEF1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
  • 基因功能參考文獻(xiàn)：
    1. Data suggest that MCP1/CCL2 induces activation/tyrosine phosphorylation of ARHGEF1/p115-RhoGEF and up-regulates RAC1 signaling in vascular smooth muscle cells (VSMCs); ARHGEF1 inhibition suppresses MCP1-induced VSMC migration and proliferation. (ARHGEF1 = Rho guanine nucleotide exchange factor 1; RAC1 = Rac family small GTPase 1; CCL2 = C-C motif chemokine ligand 2) PMID: 28655771
    2. Data indicate that the crystal structure of PDZ-RhoGEF PDZ domain in complex with the CXC chemokine receptor 2 (CXCR2) C-terminal PDZ binding motif. PMID: 28179147
    3. We have reported here for the first time a reduced activity of both Rac1 and Cdc42 in human pheochromocytoma resection as well as tumor-associated expression changes of FARP1, ARHGEF1, and ARHGAP36 PMID: 26911374
    4. contactin-1 displayed the ability to phosphorylate the RhoA activator p115 RhoGEF PMID: 25916117
    5. The novel role for p115RhoGEF in regulation of epithelial plasticity is dependent on Rho-DRF signaling module. PMID: 24465552
    6. Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs). PMID: 24855647
    7. Modification of p115RhoGEF at Serine(330) regulates its RhoGEF activity. PMID: 23816534
    8. The action of DOCK7 in vivo may involve the coordinated integration of Cdc42/Rac1 signaling in the context of the membrane recruitment of a DOCK7 guanine nucleotide exchange factor (GEF) complex. PMID: 23718289
    9. High GEF1 expression is associated with metastasis of pancreatic cancer. PMID: 23070684
    10. Activation of p115-RhoGEF requires direct association of Galpha13 and the Dbl homology domain. PMID: 22661716
    11. Upon beta(2)AR activation, both betaArrestin2 and p115RhoGEF translocate to the plasma membrane, with concomitant activation of RhoA and formation of focal adhesions and stress fibers. PMID: 22500016
    12. Thromboxane receptor signaling is required for fibronectin-induced matrix metalloproteinase 9 production by human and murine macrophages and is attenuated by the Arhgef1 molecule. PMID: 22086927
    13. Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG). PMID: 21454492
    14. The linker region connecting the N-terminal RGS-homology domain and the Dbl homology domain inhibits the intrinsic guanine nucleotide exchange activity of p115. PMID: 21064165
    15. ARHGEF1 is involed in hypertension by controlling its molecular mechanisms. PMID: 20619149
    16. coexpression of a dominant negative PDZ-RhoGEF abrogated the ability of plexin-B1 to cause stress fiber formation PMID: 12372594
    17. rgRGS domain may serve a structural or allosteric role in the regulation of the nucleotide exchange activity of p115RhoGEF on Rho by Galpha(13) PMID: 12525488
    18. CD44 interaction with p115RhoGEF and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3-kinase membrane localization, AKT signaling, and cytokine (M-CSF) production during HA-mediated breast cancer progression PMID: 12748184
    19. data demonstrate a pathway of Rho activation involving protein kinase c alpha-dependent phosphorylation of p115Rho guanine exchange factor PMID: 12754211
    20. Data show that different rho guanine nucleotide exchange factors (rhoGEFs; p115rhoGEF, LARG and PDZrhoGEF) mediate downstream rho signaling by the thrombin and lysophosphatidic acid receptors. PMID: 15143072
    21. Several features of a typical alpha/RGS interaction are preserved in the alpha(13)/p115RhoGEF interaction. PMID: 15735747
    22. analysis of a novel cross-talk exerted from the LPA/Galpha(13)/p115RhoGEF/RhoA pathway to the beta(2)-adrenergic receptor/Galpha(s)/adenylyl cyclase pathway PMID: 17493936
    23. A pronounced and rapid translocation of p115-RhoGEF from the cytosol to the plasma membrane was observed upon activation of several G(12/13)-coupled receptors in a cell type-independent fashion. PMID: 18320579
    24. Data show that microtubules in neighboring cells reorient and target p115 RhoGEF to sites where dying cells are squeezed out of the epithelial sheet. PMID: 19720875

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or LPA stimulation.
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 681

    OMIM: 601855

    KEGG: hsa:9138

    STRING: 9606.ENSP00000337261

    UniGene: Hs.631550



主站蜘蛛池模板： 私人毛片免费高清影视院| 亚洲女教师丝祙在线播放| 国产在线无码一区二区三区 | 久久成人国产精品无码| 曰的好深好爽免费视频网站| 国产一区视频一区欧美| 131mm少妇做爰视频| 老妇女性较大毛片| 色欲久久久天天天综合网精品| 国产在线观看精品一区二区三区| 少妇性荡欲视频| 日本一卡二卡四卡无卡国产| 性高湖久久久久久久久aaaaa| 护士脱了内裤让我爽了一夜视频| 亚州中文字幕无码中文字幕| 人人莫人人擦人人看| 夜夜躁天天躁很很躁| 成人欧美一区二区三区黑人| 秋霞鲁丝片av无码| av无码国产精品色午夜| 国产乱子伦在线一区二区| 天天躁日日躁狠狠躁一区| 国产精品成人网站| 制服丝袜有码中文字幕在线| 99国精品午夜福利视频不卡| 欧美老妇交乱视频在线观看| 国产人与禽zoz0性伦| 伊人伊成久久人综合网996| 国产精品久久久一区二区三区 | 大桥未久亚洲一区二区| 免费国产成人午夜福利电影| 97丨九色丨国产人妻熟女| аⅴ天堂中文在线网| 国产免费爽爽视频| 亚洲国产精品无码久久久蜜芽| 欧美性黑人极品hd| 成人区人妻精品一区二区不卡视频| 狠狠色丁香婷婷综合尤物| 久久久久久综合岛国免费观看| 日本少妇高潮喷水xxxxxxx| 久久久综合香蕉尹人综合网|