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  4. Recombinant Human Regulator of nonsense transcripts 2 (UPF2), partial

Recombinant Human Regulator of nonsense transcripts 2 (UPF2), partial

  • 中文名稱：
    人UPF2重組蛋白
  • 貨號：
    CSB-YP867186HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人UPF2重組蛋白
  • 貨號：
    CSB-EP867186HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人UPF2重組蛋白
  • 貨號：
    CSB-EP867186HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人UPF2重組蛋白
  • 貨號：
    CSB-BP867186HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人UPF2重組蛋白
  • 貨號：
    CSB-MP867186HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    UPF2
  • Uniprot No.：
  • 別名：
    DKFZp434D222; hUpf2; KIAA1408; MGC138834; MGC138835; Nonsense mRNA reducing factor 2; Regulator of nonsense transcripts 2; RENT2; RENT2_HUMAN; Smg 3; Smg 3 homolog nonsense mediated mRNA decay factor; Up-frameshift suppressor 2 homolog; UPF2; UPF2 regulator of nonsense transcripts homolog; UROC1; Urocanate hydratase; Yeast Upf2p homolog
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.
  • 基因功能參考文獻：
    1. UPF2 binds the FRB domain of SMG1, a region that regulates the related mTOR kinase. PMID: 25002321
    2. UPF2 MIF4G-1 and MIF4G-2 domains appear to have a crucial scaffolding role, while the MIF4G-3 domain is the key module required for triggering nonsense-mediated decay. PMID: 24271394
    3. Data show that upon binding to Upf2, the regulatory CH domain of Upf1 undergoes a large conformational change, causing the catalytic helicase domain to bind RNA less extensively and triggering its helicase activity. PMID: 21419344
    4. The authors propose that the bipartite mode of UPF2 binding to UPF1 brings the ribosome and the exon junction complex in close proximity by forming a tight complex after an initial weak encounter with either element. PMID: 19556969
    5. The complex between the interacting domains of human UPF2 and UPF3b at a 1.95 A resolution. PMID: 15004547
    6. During nonsense-mediated mRNA decay, CBP80 interacts with Upf1 and promotes the interaction of Upf1 with Upf2 but not with Stau1. PMID: 16186820
    7. UPF2-silenced HeLa cells were impaired in their ability to recognize ectopically expressed aberrant premature termination codon transcripts PMID: 16449641
    8. The Upf complex communicates with the exon-junction complex and triggers nonsense-mediated decay in the cytoplasm. PMID: 17803942
    9. UPF2 and UPF3b cooperatively stimulate both ATPase and RNA helicase activities of UPF1. PMID: 18066079

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  • 亞細胞定位：
    Cytoplasm, perinuclear region.
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 17854

    OMIM: 605529

    KEGG: hsa:26019

    STRING: 9606.ENSP00000348708

    UniGene: Hs.370689



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