在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Regulator of nonsense transcripts 2 (UPF2), partial

  • 中文名稱:
    人UPF2重組蛋白
  • 貨號:
    CSB-YP867186HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人UPF2重組蛋白
  • 貨號:
    CSB-EP867186HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人UPF2重組蛋白
  • 貨號:
    CSB-EP867186HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人UPF2重組蛋白
  • 貨號:
    CSB-BP867186HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人UPF2重組蛋白
  • 貨號:
    CSB-MP867186HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    UPF2
  • Uniprot No.:
  • 別名:
    DKFZp434D222; hUpf2; KIAA1408; MGC138834; MGC138835; Nonsense mRNA reducing factor 2; Regulator of nonsense transcripts 2; RENT2; RENT2_HUMAN; Smg 3; Smg 3 homolog nonsense mediated mRNA decay factor; Up-frameshift suppressor 2 homolog; UPF2; UPF2 regulator of nonsense transcripts homolog; UROC1; Urocanate hydratase; Yeast Upf2p homolog
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.
  • 基因功能參考文獻:
    1. UPF2 binds the FRB domain of SMG1, a region that regulates the related mTOR kinase. PMID: 25002321
    2. UPF2 MIF4G-1 and MIF4G-2 domains appear to have a crucial scaffolding role, while the MIF4G-3 domain is the key module required for triggering nonsense-mediated decay. PMID: 24271394
    3. Data show that upon binding to Upf2, the regulatory CH domain of Upf1 undergoes a large conformational change, causing the catalytic helicase domain to bind RNA less extensively and triggering its helicase activity. PMID: 21419344
    4. The authors propose that the bipartite mode of UPF2 binding to UPF1 brings the ribosome and the exon junction complex in close proximity by forming a tight complex after an initial weak encounter with either element. PMID: 19556969
    5. The complex between the interacting domains of human UPF2 and UPF3b at a 1.95 A resolution. PMID: 15004547
    6. During nonsense-mediated mRNA decay, CBP80 interacts with Upf1 and promotes the interaction of Upf1 with Upf2 but not with Stau1. PMID: 16186820
    7. UPF2-silenced HeLa cells were impaired in their ability to recognize ectopically expressed aberrant premature termination codon transcripts PMID: 16449641
    8. The Upf complex communicates with the exon-junction complex and triggers nonsense-mediated decay in the cytoplasm. PMID: 17803942
    9. UPF2 and UPF3b cooperatively stimulate both ATPase and RNA helicase activities of UPF1. PMID: 18066079

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, perinuclear region.
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 17854

    OMIM: 605529

    KEGG: hsa:26019

    STRING: 9606.ENSP00000348708

    UniGene: Hs.370689



主站蜘蛛池模板: 国产永久免费观看的黄网站| 小泽玛莉亚一区二区视频在线| 最新色国产精品精品视频| 宅男午夜成年影视在线观看| 无码中文字幕av免费放dvd| 成人h动漫精品一区二区无码| 精品久久久久久综合日本| 神马午夜福利不卡片在线| 亚洲人成77777在线播放网站不卡| 国产suv精品一区二区69| 狠狠色丁香久久婷婷综合图片| 国产精品国产三级国产an| 日韩亚洲国产主播在线不卡| 亚洲熟女乱色综合亚洲小说| 亚洲精品电影院| 强伦姧人妻免费无码电影| 国内精品久久久久av福利秒拍| 成人永久免费网站在线观看| 精品噜噜噜噜久久久久久久久 | 麻豆果冻传媒2021精品传媒一区| 卡一卡二卡三免费视频 | 国产孩cao大人xxxx| 99精品国产一区二区三区不卡| 国产精品xxx在线| 成在人线av无码免观看| 高中生粉嫩无套第一次| 国精产品一区一区三区mba下载| (无码视频)在线观看| 在线无码免费的毛片视频| 亲近乱子伦免费视频| 无码人妻精品一区二区三区99不卡| 国产一卡三卡四卡无卡精品| 把腿张开老子臊烂你多p视频| 国产精品 视频一区 二区三区| 免费无码一区二区三区a片| 99久久亚洲综合精品成人| 成视频年人黄网站免费视频| 人妻aⅴ无码一区二区三区| 国产精品国产三级国产剧情| 一个人看的免费高清www视频| 玩弄少妇高潮ⅹxxxyw|