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  4. UPF2 Antibody

UPF2 Antibody

  • 中文名稱：
    UPF2兔多克隆抗體
  • 貨號：
    CSB-PA867186DSR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA867186DSR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) UPF2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    UPF2
  • 別名：
    DKFZp434D222 antibody; hUpf2 antibody; KIAA1408 antibody; MGC138834 antibody; MGC138835 antibody; Nonsense mRNA reducing factor 2 antibody; Regulator of nonsense transcripts 2 antibody; RENT2 antibody; RENT2_HUMAN antibody; Smg 3 antibody; Smg 3 homolog nonsense mediated mRNA decay factor antibody; Up-frameshift suppressor 2 homolog antibody; UPF2 antibody; UPF2 regulator of nonsense transcripts homolog antibody; UROC1 antibody; Urocanate hydratase antibody; Yeast Upf2p homolog antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Regulator of nonsense transcripts 2 protein (1153-1272AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.
  • 基因功能參考文獻：
    1. UPF2 binds the FRB domain of SMG1, a region that regulates the related mTOR kinase. PMID: 25002321
    2. UPF2 MIF4G-1 and MIF4G-2 domains appear to have a crucial scaffolding role, while the MIF4G-3 domain is the key module required for triggering nonsense-mediated decay. PMID: 24271394
    3. Data show that upon binding to Upf2, the regulatory CH domain of Upf1 undergoes a large conformational change, causing the catalytic helicase domain to bind RNA less extensively and triggering its helicase activity. PMID: 21419344
    4. The authors propose that the bipartite mode of UPF2 binding to UPF1 brings the ribosome and the exon junction complex in close proximity by forming a tight complex after an initial weak encounter with either element. PMID: 19556969
    5. The complex between the interacting domains of human UPF2 and UPF3b at a 1.95 A resolution. PMID: 15004547
    6. During nonsense-mediated mRNA decay, CBP80 interacts with Upf1 and promotes the interaction of Upf1 with Upf2 but not with Stau1. PMID: 16186820
    7. UPF2-silenced HeLa cells were impaired in their ability to recognize ectopically expressed aberrant premature termination codon transcripts PMID: 16449641
    8. The Upf complex communicates with the exon-junction complex and triggers nonsense-mediated decay in the cytoplasm. PMID: 17803942
    9. UPF2 and UPF3b cooperatively stimulate both ATPase and RNA helicase activities of UPF1. PMID: 18066079

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  • 亞細胞定位：
    Cytoplasm, perinuclear region.
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 17854

    OMIM: 605529

    KEGG: hsa:26019

    STRING: 9606.ENSP00000348708

    UniGene: Hs.370689



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