在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Ras-responsive element-binding protein 1 (RREB1), partial

Recombinant Human Ras-responsive element-binding protein 1 (RREB1), partial

  • 中文名稱：
    人RREB1重組蛋白
  • 貨號：
    CSB-YP846096HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RREB1重組蛋白
  • 貨號：
    CSB-EP846096HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RREB1重組蛋白
  • 貨號：
    CSB-EP846096HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RREB1重組蛋白
  • 貨號：
    CSB-BP846096HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RREB1重組蛋白
  • 貨號：
    CSB-MP846096HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RREB1
  • Uniprot No.：
  • 別名：
    FINB; Finger protein in nuclear bodies; Hindsight homolog; HNT; LZ321; Raf responsive zinc finger protein LZ321; Raf-responsive zinc finger protein LZ321; RAS responsive element binding protein 1; Ras-responsive element-binding protein 1; RREB 1; RREB-1; Rreb1; RREB1_HUMAN; Zep 1; Zep-1; Zep1; Zinc finger motif enhancer binding protein 1; Zinc finger motif enhancer-binding protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. Promotes brown adipocyte differentiation. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression.
  • 基因功能參考文獻：
    1. Of the 465,447 CpG sites analyzed, 12 showed differential methylation (false discovery rate <0.15), including markers within genes associated with monogenic diabetes (HNF4A) or obesity (RREB1). The overall methylation at HNF4A showed inverse correlations with mRNA expression levels, though non significant PMID: 29099273
    2. RREB1 cooperates with noncoding RNA linc-ADAMTS5 to inhibit ADAMTS5 expression, thereby affecting degeneration of the extracellular matrix (ECM) of the intervertebral disc. PMID: 28341660
    3. RREB1 and CCND1 gains are common in nail apparatus melanoma PMID: 27185405
    4. Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome. PMID: 26608785
    5. RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease. PMID: 25027322
    6. The pathway of RREB1/ZIP3/Zinc and its downregulation during oncogenesis exist to prevent the accumulation of cytotoxic levels of zinc during the development and progression of the malignant cells in pancreatic adenocarcinoma. PMID: 25050557
    7. RREB-1 overexpression results in down-regulation of hZIP1 and contributes to the loss of hZIP1 expression and zinc in prostate cancer. PMID: 21360563
    8. Thus HNT and c are functional homologs at the level of DNA binding, transcriptional regulation and developmental control PMID: 24418439
    9. Data show the transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level. PMID: 24348900
    10. RREB1 is overexpressed in colorectal adenocarcinoma tumors. RREB1 repressed miR-143/145 modulates KRAS signaling. PMID: 22751122
    11. These results support a concept that downregulation of RREB-1 causes downregulation of ZIP3, which results in decreased zinc in pancreatic premalignant and carcinoma cells PMID: 22427155
    12. Data indicate the upregulation of RREB1, PDE6B, and CD209 suggests that these proteins might play important roles in the differentiation of primitive gut tube cells from embryonic stem cells (hESCs) and in primitive gut tube development into pancreas. PMID: 21792086
    13. Data show that the combination of concurrent zinc, ZIP3, and RREB-1 changes represent early events in the development of adenocarcinoma. PMID: 21613827
    14. RREB1 transcription factor splice variants are associated with urologic cancer. PMID: 21703425
    15. KRAS and RREB1 are targets of miR-143/miR-145, revealing a feed-forward mechanism that potentiates Ras signaling PMID: 21159816
    16. Ras pathway and activation of RREB-1 are involved in hZIP1 down-regulation and may play a role in the decrease of the transporter expression in prostate cancer. PMID: 19802870
    17. The p16 promoter can be downregulated by transfected human RREB, in a Ras- or Mek-dependent manner, and that the BALB/c promoter is more sensitive than DBA/2 to regulation by RREB, a ras-responsive transcriptional element with zinc-finger binding motifs. PMID: 12700664
    18. Finb functions as a sequence-specific transcriptional repressor of the hANG gene PMID: 15067362
    19. essential to reduce cell-cell adhesion when epithelial cells within an interconnected group undergo dynamic changes in cell shape PMID: 18394891
    20. Findings provide evidence that RREB-1 participates in modulating p53 transcription in response to DNA damage. PMID: 19558368
    21. This demonstration is the first of a repressor factor of HLA-G transcriptional activity taking part in HLA-G repression by epigenetic mechanisms. PMID: 19890057

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus speckle.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 組織特異性：
    Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain.
  • 數據庫鏈接：

    HGNC: 10449

    OMIM: 602209

    KEGG: hsa:6239

    UniGene: Hs.298248



主站蜘蛛池模板： 国产精品成人永久在线| 隔壁人妻偷人bd中字| 久久久亚洲欧洲日产国产成人无码| 国产成人免费97在线| 伊人久久大香线蕉aⅴ色| 国产裸体xxxx视频| 国产女人高潮毛片| 国产精品无码久久久久久久久久| 亚洲高清乱码午夜电影网 | 俄罗斯少妇性xxxx另类| а天堂中文在线官网在线| 在线播放亚洲第一字幕| 正在播放的国产a一片| 亚洲 欧美精品suv| 国产精品v片在线观看不卡| 窝窝影院午夜看片| 国产丝袜在线精品丝袜不卡| 日本真人边吃奶边做爽电影| 丁香五月欧美成人| 国产精品丝袜久久久久久不卡| 影音先锋日日狠狠久久| 18女下面流水不遮图| 精品国产乱码久久久久久1区2区| 18禁勿入网站入口永久| 国产成人无码激情视频| 国产又粗又大又黄| 精品无码一区二区三区电影| 亚洲综合色在线观看一区| 精品无码国产一区二区三区av| 亚洲乱码日产精品bd在线观看| 日产乱码一区二区三区在线| 最美女人体内射精一区二区| 国产人久久人人人人爽| 熟妇人妻无码xxx视频| 国产午夜福利不卡在线观看| 国产又色又爽又刺激在线播放| 97视频在线观看播放| 亚洲成av人在线观看天堂无码| 国产精品乱码高清在线观看| 色拍拍在线精品视频| 久久婷婷人人澡人人爽人人喊|